Clinical use of gastric antisecretory drugs in pediatric patients with gastroesophageal reflux disease: a narrative review

Cuzzolin, Laura; Locci, Cristian; Chicconi, Elena; Antonucci, Roberto

doi:10.21037/tp-22-401

Cited by 5 publications

(4 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While the results showed that PPIs are the treatment of choice in pediatric GERD for patients aged 1 year and up, it did not find them useful in treating children under the age of 1 year that presented with unspecific symptoms such as crying, irritability, or apnea, particularly when they had no proven esophagitis or complications due to gastroesophageal reflux. Also, it concluded that there is no strong evidence in treating with PPIs asthma symptoms in children with GERD as they might actually be caused by the quantity of refluxed fluid and not by its quality, i.e., by its pH [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Is There a Potential Link between Gastroesophageal Reflux Disease and Recurrent Respiratory Tract Infections in Children?

Lupu,

Stefanescu,

Buga

et al. 2023

Diagnostics

View full text Add to dashboard Cite

Background: The implications of gastroesophageal reflux disease in respiratory tract infections have been investigated over time. The aim of our study was to evaluate the relationship between these two pathologic entities and the outcome after proper antireflux treatment. Methods: A group of 53 children with recurrent respiratory tract infections admitted in the gastroenterology clinic of a children’s hospital in North-East Romania was investigated for gastroesophageal reflux disease through 24 h pH-metry. Those with a Boix-Ochoa score higher than 11.99 received proton pump inhibitor treatment and were reevaluated after 2 months. Results: A total of 41 children were found with a positive Boix-Ochoa score. After 2 months of antireflux therapy, eight patients still had a positive Boix-Ochoa score. Conclusions: Recurrent respiratory tract infections with symptoms resistant to treatment should be considered a reason to investigate for gastroesophageal reflux, because the symptoms may be due to micro- or macro-aspiration of the gastric refluxate or to an esophageal-bronchial reflex mediated through the vagal nerve.

show abstract

Section: Discussionmentioning

confidence: 99%

Is There a Potential Link between Gastroesophageal Reflux Disease and Recurrent Respiratory Tract Infections in Children?

Lupu,

Stefanescu,

Buga

et al. 2023

Diagnostics

View full text Add to dashboard Cite

show abstract

“…The management for GER was classified based on the following treatment plan [1,3,23,26–28] : grade 0 (Fig. 1), non-pharmacological treatment, such as body positioning, and feeding modifications, including decreased feed volume and slower feeding; grade 1 (Fig.…”

Section: Methodsmentioning

confidence: 99%

“…Central nervous system disorders that required medical support included mental retardation, epilepsy, intraventricular hemorrhage, cerebral palsy, and hypoxic-ischemic encephalopathy. [20][21][22][23][24][25] The management for GER was classified based on the following treatment plan [1,3,23,[26][27][28] : grade 0 (Fig. 1), non-pharmacological treatment, such as body positioning, and feeding modifications, including decreased feed volume and slower feeding; grade 1 (Fig.…”

Section: Patients' Characteristics and Classificationmentioning

confidence: 99%

A single-center experience of using milk scintigraphy in 251 pediatric patients: A retrospective study

Takahiro,

Uchiyama,

Tanami

et al. 2023

Medicine

View full text Add to dashboard Cite

To report our experience with milk gastroesophageal scintigraphy and the management of gastroesophageal reflux (GER) in children. In 251 pediatric patients we recorded age, underlying disease, central nervous system (CNS) disorders, and GER management. GER management was classified based on treatment plans: grade 0, non-pharmacological treatment; grade 1, non-pharmacological but using a nasogastric tube; grade 2, pharmacological treatment; grade 3, transpyloric feeding; and grade 4, Nissen fundoplication surgery. Patients were included in classified groups with (grades 2, 3, and 4) and without (grades 0 and 1) GER treatment. We evaluated the GER height (classified based on the height of GER, grade 0; no GER, 1; GER in the lower esophagus, 2; GER in the upper esophagus), GER duration in the lower and upper esophagus, presence or absence of massive GER amounts in the lower and upper esophagus, and gastric emptying time. We compared milk scintigraphy results and patient characteristics between groups with (grades 2, 3, and 4) and without (grades 0 and 1) GER treatment. We treated 121 patients for GER. CNS disorders (presence/absence: 46/74 with vs 21/110 without treatment, P < .001). The GER height grade (1.7 ± 0.5 [range, 0–2] with vs 1.5 ± 0.7 [range, 0–2] without treatment, P = .002), massive GER amount (present/absent: 21/99 with vs 9/122 without treatment, P = .011), and duration of GER (seconds) (324.5 ± 508.3 [range, 0–1800] vs 125.0 ± 291.9 [range, 0–1750], P < .001) in the upper esophageal half differed significantly. Similarly massive GER amount (present/absent: 54/66 with vs 34/97 without treatment, P = .002) and GER duration (621.3 ± 601.0 [range, 0–1800] vs 349.8 ± 452.4 [range, 0–1800], P < .001) in the lower esophageal half differed significantly. Additionally, CNS disorders, age, and massive GER in the upper esophageal half differed significantly among grades 2 and 4 in treated patients (P < .05, P < .001, P < .05, respectively). Milk scintigraphy is useful for deciding whether GER treatment is indicated. However, the treatment plan needs to be decided based on each patient’s condition.

show abstract

“…In addition, continuous stimulation by aggressive factors induces gastric mucosal inflammation, which can develop into gastric ulcers and cancer; therefore, it is crucial to control this mechanism 14 , 15 . Drugs such as ranitidine, omeprazole, and cimetidine are used to protect and treat the gastric mucosa against these aggressive factors; however, because of the side effects caused by these drugs, it is necessary to develop other safe and effective therapeutic drugs 13 , 16 , 17 .…”

Section: Introductionmentioning

confidence: 99%

Comparative Morphology of Island and Inland Agastache rugosa and Their Gastroprotective Effects in EtOH/HCl-Induced Gastric Mucosal Gastritis

Song,

Nam,

Park

et al. 2023

Planta Med

View full text Add to dashboard Cite

Agastache rugosa Kuntze (Lamiaceae; Labiatae), a medicinal and functional herb used to treat gastrointestinal diseases, grows well both on islands and inland areas in South Korea. Thus, we aimed to reveal the morphological and micromorphological differences between A. rugosa grown on island and inland areas and their pharmacological effects on gastritis in an animal model by combining morphological and mass spectrophotometric analyses. Morphological analysis showed that island A. rugosa had slightly smaller plants and leaves than inland plants; however, the density of all types of trichomes on the leaves, petioles, and stems of island A. rugosa was significantly higher than that of inland plants. The essential oil component analysis revealed that pulegone levels were substantially higher in island A. rugosa than in inland A. rugosa. Despite the differences between island and inland A. rugosa, treatment with both island and inland A. rugosa reduced gastric damages by more than 40% compared to the gastritis induction group. In addition, expression of inflammatory protein was reduced by about 30% by treatment of island and inland A. rugosa. The present study demonstrates quantitative differences in morphology and volatile components between island and inland plants; significant differences were not observed between the gastritis-inhibitory effects of island and inland A. rugosa, and the efficacy of island A. rugosa was found to be similar to that of A. rugosa grown in inland areas.

show abstract

Clinical use of gastric antisecretory drugs in pediatric patients with gastroesophageal reflux disease: a narrative review

Cited by 5 publications

References 61 publications

Is There a Potential Link between Gastroesophageal Reflux Disease and Recurrent Respiratory Tract Infections in Children?

Is There a Potential Link between Gastroesophageal Reflux Disease and Recurrent Respiratory Tract Infections in Children?

A single-center experience of using milk scintigraphy in 251 pediatric patients: A retrospective study

Comparative Morphology of Island and Inland Agastache rugosa and Their Gastroprotective Effects in EtOH/HCl-Induced Gastric Mucosal Gastritis

Contact Info

Product

Resources

About