Clinical Use of Micronized Purified Flavonoid Fraction for Treatment of Symptoms After Hemorrhoidectomy: Results of a Randomized, Controlled, Clinical Trial

Torre, Filippo La; Nicolai, Albano

doi:10.1007/s10350-003-0119-1

Cited by 78 publications

(68 citation statements)

References 25 publications

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“…The ROS in the pancreatic tissues were significantly higher in CRL-induced rats than in the control animals in our study, and our results conform to those previously reported in literature (4,8,24). This study demonstrates the powerful therapeutic potential of the concomitant use of 2 agents-HES (17)(18)(19) and ENX (12,13,15)-that are clinically applied for their anticoagulant or anti-inflammatory properties. To our knowledge, ours is the first study where HES was used to treat acute pancreatitis.…”

Section: Discussionsupporting

confidence: 92%

“…Both these drugs reduced all the parameters of acute pancreatitis by nearly 50%, in agreement with their anti-inflammatory and/or antioxidant properties (12)(13)(14)(17)(18)(19)(20)(21)(22)35,36,44). The possible additive effects of ENX and HES were also investigated in this study.…”

Section: Discussionsupporting

confidence: 64%

“…On the other hand, as a member of the bioflavonoids, HES has antioxidant, anti-inflammatory, and anti-neoplastic effects (17,18). HES has been reported to be an effective anti-oxidizing agent that can scavenge ROS (44).…”

Section: Discussionmentioning

confidence: 99%

“…HES is a flavonoid with strong anti-inflammatory effects. It is a powerful ROS scavenger that increases tissue perfusion and functions as a microcapillary regulator (17)(18)(19)(20)(21)(22). However, no studies have yet investigated the use of HES for treating patients with acute pancreatitis.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Preventive effects of enoxaparin and hesperidin in cerulein-induced acute pancreatitis in rats

Yankol²,

E³

et al. 2013

Turk J Gastroenterol

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show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preventive effects of enoxaparin and hesperidin in cerulein-induced acute pancreatitis in rats

Yankol²,

E³

et al. 2013

Turk J Gastroenterol

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show abstract

“…Direct application of very low doses of opioid agonist in the absorbable sponge dressing placed in the anus at the end of the surgical procedure is also effective [34]. Flavonoids may contribute to reduce postoperative pain [35,36]. Regardless of the above mentioned methods used, effective postoperative pain management is required.…”

Section: Complicationsmentioning

confidence: 99%

Clinical Outcome Following Hemorrhoid Surgery: a Narrative Review

Picchio¹,

Greco²,

Filippo

et al. 2014

Indian J Surg

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Surgical therapy guaranties satisfactory results, which are significantly better than those obtained with conservative therapies, especially for Grade III and IV hemorrhoids. In this review, we present and discuss the results of the most diffuse surgical techniques for hemorrhoids. Traditional surgery for hemorrhoids aims to remove the hemorrhoids, with closure (Fergusson's technique) or without closure (Milligan-Morgan procedure) of the ensuing defect. This traditional approach is effective, but causes a significant postoperative pain because of wide external wounds in the innervated perianal skin. Stapled hemorrhoidopexy, proposed by Longo, has gained a vast acceptance because of less postoperative pain and faster return to normal activities. In the recent literature, a significant incidence of recurrence after stapled hemorrhoidopexy was reported, when compared with conventional hemorrhoidectomy. Double stapler hemorrhoidopexy may be an alternative to simple stapled hemorrhoidopexy to reduce the recurrence in advanced hemorrhoidal prolapse. Transanal hemorrhoidal deartertialization was showed to be as effective as stapled hemorrhoidopexy in terms of treatment success, complications, and incidence recurrence. However, further high-quality trials are recommended to assess the efficacy and safety of this technique.

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Phlebotonics for haemorrhoids

Perera

Liolitsa

Iype

et al. 2012

Cochrane Database of Systematic Reviews

101

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The evidence suggests that there is a potential benefit in using phlebotonics in treating haemorrhoidal disease as well as a benefit in alleviating post-haemorrhoidectomy symptoms. Outcomes such as bleeding and overall symptom improvement show a statistically significant beneficial effect and there were few concerns regarding their overall safety from the evidence presented in the clinical trials.However methodological limitations were encountered. In order to enhance our conclusion further, more robust clinical trials which take into account these limitations will need to be performed in the future.

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Clinical Use of Micronized Purified Flavonoid Fraction for Treatment of Symptoms After Hemorrhoidectomy: Results of a Randomized, Controlled, Clinical Trial

Abstract: Micronized purified flavonoid fraction used in combination with short-term antibiotic and anti-inflammatory treatment can reduce both the duration and extent of postoperative symptoms and wound bleeding following hemorrhoidectomy.

Cited by 78 publications

References 25 publications

Preventive effects of enoxaparin and hesperidin in cerulein-induced acute pancreatitis in rats

Preventive effects of enoxaparin and hesperidin in cerulein-induced acute pancreatitis in rats

Clinical Outcome Following Hemorrhoid Surgery: a Narrative Review

Phlebotonics for haemorrhoids

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