Clinical Use of Tolterodine Extended Release in Overactive Bladder

Abstract

Abstract:Overactive bladder (OAB) is a common problem whose prevalence increases with advancing age and compromises health-relatedqualityoflife.TolterodinewasthefirstantimuscarinicdrugspecificallydesignedtotreatOAB. ThroughMEDLINE,wereviewedarticles,standardizationreportsandmeetingabstracts,publishedbetween2001and2011,ontheefficacy and tolerability of Tolterodine extended release (ER). Our search terms included Tolterodine, extended release, overactive bladder, therapeuticuse,efficacy,tolerance,andadverseevents. TolterodineER,viasteadydrugreleaseduringthedaytime,givesthebenefitofconstantserumconcentrationandthusbetterefficacy and tolerability in comparison to Tolterodine immediate release, even in elderly patients with co-morbid conditions.