Clinical Usefulness of [(18)F] Fluoro-2-Deoxy-d-Glucose Uptake in 178 Head-and-Neck Cancer Patients With Nodal Metastasis Treated With Definitive Chemoradiotherapy: Consideration of Its Prognostic Value and Ability to Provide Guidance for Optimal Selection of Patients for Planned Neck Dissection

Inokuchi, Haruo; Kodaira, Takeshi; Tachibana, Hideki; Nakamura, Tatsuya; Tomita, Natsuo; Nakahara, Rie; Takada, Akinori; Mizoguchi, Nobutaka; Tamaki, Tsuneo; Fuwa, Nobukazu

doi:10.1016/j.ijrobp.2009.11.034

Cited by 35 publications

(25 citation statements)

References 21 publications

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“…In line with the present results, Chan et al (12) reported that SUVmax-N appeared to be more powerful in predicting distant failure than SUVmax-P. This phenomenon has also been noted in previous studies of non-NPC head and neck cancer (35)(36)(37). It is generally accepted that inflammation may contribute to the initiation and progression of cancer.…”

Section: Discussionsupporting

confidence: 91%

Prognostic value of 18F-fluorodeoxyglucose PET parameters and inflammation in patients with nasopharyngeal carcinoma

Zhong

Ren

et al. 2017

Oncology Letters

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Abstract. The aim of the present study was to investigate the association between positron emission tomography (PET) parameters and peripheral inflammatory markers, and assess their prognostic value in nasopharyngeal carcinoma (NPC). A total of 121 patients with non-disseminated NPC were recruited. Pretreatment maximum standardized uptake values (SUVmax) of PET and peripheral inflammatory factors (leukocyte, neutrophil and monocyte counts) were recorded. Kaplan-Meier and multivariate analyses were used to identify predictors for progression-free survival (PFS), overall survival (OS), distant metastasis-free survival (DMFS) and locoregional recurrence-free survival (LRFS). The results of the present study revealed that SUVmax at the primary tumor was positively correlated with leukocytes (P= 0.025), neutrophils (P= 0.009) and monocytes (P= 0.043). SUVmax at regional lymph nodes (SUVmax-N) was significantly associated with monocytes (P= 0.024). Kaplan-Meier analysis demonstrated that SUVmax-N (>10.15) significantly predicted PFS (P=0.004) and DMFS (P= 0.003). In addition, neutrophils (>5.18) were significantly associated with PFS (P= 0.001), DMFS (P= 0.013) and LRFS (P<0.001). Multivariate analysis revealed that SUVmax-N and neutrophils retained independent prognostic significance for PFS (SUVmax-N, P= 0.026; and neutrophils, P=0.033) and DMFS (SUVmax-N, P=0.026; and neutrophils, P= 0.032). Furthermore, patients with SUVmax-N ≤10.15 and neutrophils ≤5.18 had significantly improved prognosis in PFS (96.4 vs. 58.5%, P<0.001), OS (95.7 vs. 81.1%, P=0.044), DMFS (96.4 vs. 67.0%, P<0.001) and LRFS (100 vs. 90.2%, P= 0.036) compared with those with SUVmax-N >10.15 or neutrophils >5.18. In conclusion, SUVmax may be significantly associated with cancer-associated inflammation. SUVmax-N and neutrophils were independent prognostic indicators for PFS and DMFS. Combined assessment of SUVmax-N and neutrophils may lead to refinement of risk stratification in NPC.

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Section: Discussionsupporting

confidence: 91%

Prognostic value of 18F-fluorodeoxyglucose PET parameters and inflammation in patients with nasopharyngeal carcinoma

Zhong

Ren

et al. 2017

Oncology Letters

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“…On the one hand is the risk of neck recurrences or microscopic residual disease, on the other hand is the probability of an overtreatment with possible surgical complications (lymphedema, dysphagia, fistulae) [2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72]. Benefits may include local regional control and OS [6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,…”

Section: Introduction: Pros and Consmentioning

confidence: 99%

“…However, for clinically residual lymph node metastasis following CRT, ND remains essential [6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23]. Nevertheless, some authors continue to advocate systematically planned ND for N2–3 disease [24]. …”

Section: Introduction: Pros and Consmentioning

confidence: 99%

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The Role of Neck Dissection after Radical Chemoradiation for Locally Advanced Head and Neck Cancer: Should We Move Back?

Denaro

Russi²,

Numico³

et al. 2013

Oncology

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Until a few decades ago neck dissection (ND) was the standard surgical approach for node-positive tumours. Nowadays patients with locally advanced head and neck cancer can be treated with definitive chemoradiation (CRT), which includes the treatment of the neck; however, results on residual viable tumour after conservative treatment are heterogeneous and depend on initial node stage and primary treatment. Many authors accept adjuvant surgery in patients with N2–3 disease. Regardless of the results of upfront CRT, even if there is no evidence of lymph node metastases, when the risk for persistent positive neck nodes exceeds 15–20%, elective ND might be indicated. However, despite the diffusion of innovative technologies and therapies, there are controversies about both response evaluation and surgical management of initially involved neck nodes after definitive CRT and organ preservation treatment. In this paper we will analyse state of art of neck evaluation after CRT and discuss the role of ND.

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“…In the future SUV might be used for individualized treatment planning. Inokuchi et al [11] found that pretreatment SUV of nodal disease was one of the strongest predictive factors and also provided important information for the selection of patients suitable for planned neck dissection after chemoradiation. Unfortunately, no correction for lymph node volume was performed: due to partial volume effects smaller lymph nodes will always have lower SUV.…”

mentioning

confidence: 99%

Predictive value of fluorodeoxyglucose uptake in head and neck cancer: importance of standardization

Bree

Hoekstra

2010

Eur Arch Otorhinolaryngol

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Clinical Usefulness of [(18)F] Fluoro-2-Deoxy-d-Glucose Uptake in 178 Head-and-Neck Cancer Patients With Nodal Metastasis Treated With Definitive Chemoradiotherapy: Consideration of Its Prognostic Value and Ability to Provide Guidance for Optimal Selection of Patients for Planned Neck Dissection

Cited by 35 publications

References 21 publications

Prognostic value of 18F-fluorodeoxyglucose PET parameters and inflammation in patients with nasopharyngeal carcinoma

Prognostic value of 18F-fluorodeoxyglucose PET parameters and inflammation in patients with nasopharyngeal carcinoma

The Role of Neck Dissection after Radical Chemoradiation for Locally Advanced Head and Neck Cancer: Should We Move Back?

Predictive value of fluorodeoxyglucose uptake in head and neck cancer: importance of standardization

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