Clinical usefulness of 3% hydrogen peroxide in acute upper GI bleeding: a pilot study

Kalloo, Anthony N.; Canto, Marcia I.; Wadwa, Kalyan S.; Smith, Christine L.; Gislason, Gardar T.; Okolo, Patrick I.; Pasricha, Pankaj J.

doi:10.1016/s0016-5107(99)70055-6

Cited by 35 publications

(17 citation statements)

References 24 publications

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“…Clinical applications involving the gastrointestinal tract include relief of fecal impaction or meconium ileus, 1 detection of upper gastrointestinal bleeding, 2 and image enhancement in radiologic procedures, 3 although most of these practices have been abandoned.…”

Section: To the Editormentioning

confidence: 99%

Severe Chemical Colitis Due to Hydrogen Peroxide Enema

Love¹,

Siddiqui²,

McCallum³

et al. 2012

Journal of Clinical Gastroenterology

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Section: To the Editormentioning

confidence: 99%

Severe Chemical Colitis Due to Hydrogen Peroxide Enema

Love¹,

Siddiqui²,

McCallum³

et al. 2012

Journal of Clinical Gastroenterology

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“…In 1999, Kalloo and colleagues [17] described the use of 3% hydrogen peroxide during upper endoscopy for acute upper gastrointestinal bleeding to enhance visualization. The authors also noted the effectiveness of hydrogen peroxide in providing hemostasis in locations outside the gastrointestinal tract.…”

Section: Endoscopic Therapy For Upper Gastrointestinal Bleedingmentioning

confidence: 99%

Current therapy for nonvariceal upper gastrointestinal bleeding

2004

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Upper gastrointestinal bleeding continues to plague physicians despite the discovery of Helicobacter pylori and advances in medical therapy for peptic ulcer disease. Medical therapy with new nonsteroidal anti-inflammatory medications and somatostatin/octreotide and intravenous proton pump inhibitors provides hope for reducing the incidence of and treating bleeding peptic ulcer disease. Endoscopic therapy remains the mainstay for diagnosis and treatment of upper gastrointestinal bleeding. Many methods of endoscopic hemostasis have proven useful in upper gastrointestinal hemorrhage. Currently, combination therapy with epinephrine injection and bicap or heater probe therapy is most commonly employed in the United States. Angiography and embolization play a role primarily when endoscopic therapy is unsuccessful.

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“…The role of H 2 O 2 in bleeding was first described in a canine model where it improved visualization in experimentally induced bleeding gastric ulcers [17]. A subsequent pilot study was performed in six patients with acute upper GI bleeding [18]. A blood clearance score (BCS; Table 2) was compared after flushing with water and then with 3% H 2 O 2 .…”

mentioning

confidence: 99%

“…The authors examined the intra-observer and inter-observer agreement for the BCS score. The interobserver agreement on the BCS score between the endoscopist and the blinded observer was good with a kappa of 0.78 (95% CI 0.50-1.0; p = 0.001) before water, 0.80 Table 2 Blood clearance score (BCS) [18] Grade Description Helicobacter pylori infection was determined by the rapid urease test taken at the time of the upper endoscopy, which may have underestimated the number of patients infected. An important note in this study is that patients with clots larger than 2 cm were excluded from the study.…”

mentioning

confidence: 99%