In order to investigate the influence of patient position change on the position of catheter tip in arm infusion port, the clinical data of 324 patients undergoing arm infusion port implantation in a hospital were retrospectively analyzed. It could be obtained that TIVAP was successfully implanted in 324 patients with malignant tumors. In 171 cases, the TIVAP catheter tip shifted to the foot side when the position was changed from upright to decubitus, with an average displacement of (12.29 ± 7.48) mm; 149 cases had cephalic displacement with an average of (5.00 ± 3.79) mm; and 5 cases had no change. The position of the TIVAP catheter tip tended to shift to the foot side when the vertical position changed to the decubitus position, with an average displacement of (−9.32 ± 9.36) mm, and the difference had statistical significance (
P
<
0.0001
), while there were no significant differences in gender, age, height, weight, body mass index, and catheter tip position (
P
>
0.05
). It could be analyzed from the data that from decubitus to upright position, the tip of the arm infusion port tended to shift to the foot side, and the moving distance was related to the patient’s gender, sebum thickness, and indwelling catheter length. Preoperative understanding of relevant information is helpful to determine the location and length of catheterization and reduce catheter-related complications.