Clinical Usefulness of Propofol as an Anesthetic Induction Agent in Dogs and Cats

Sano, Tadashi; Nishimura, Ryohei; Mochizuki, Manabu; Hara, Yasushi; Tagawa, Masahiro; Sasaki, Nobuo

doi:10.1292/jvms.65.641

Cited by 34 publications

(62 citation statements)

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“…It was expected that the induction dose of propofol could be reduced depending on the sedative effects induced with each premedication. Of the premedicants used in the present study, Med induced the most profound seda- # Significantly different (P<0.05) from the induction dose of propofol in dogs without preanesthetic medication in our previous study (6.2 ± 0.5 mg/kg) [13].…”

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confidence: 55%

“…Sci. 65(10): 1141-1143, 2003 Propofol is an intravenous anesthetic which has highly desirable characteristics such as rapid onset of anesthesia, short duration of action, lack of accumulation upon repeated administration and lack of excitatory effects on induction [1,16]. Because of these beneficial characteristics, propofol is now accepted as a useful agent in dogs.…”

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confidence: 99%

“…or i.v.) was administered in AB and MB when bradycardia (HR<60) was observed during the procedure.The effects of premedications on the dose of propofol were examined by comparing them with the dose of propofol reported in the dogs without preanesthetic medication [13]. The difference in the induction dose among the premedicant groups was analyzed by one-way factorial analysis of variance (one-factor ANOVA).…”

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confidence: 99%

“…The administration of propofol was therefore smooth and the induction dose of propofol was considerably and significantly reduced as compared with the dose of propofol without preanesthetic medication [13]. It was expected that the induction dose of propofol could be reduced depending on the sedative effects induced with each premedication.…”

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Effects of Midazolam-Butorphanol, Acepromazine-Butorphanol and Medetomidine on an Induction dose of Propofol and Their Compatibility in Dogs

et al. 2003

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ABSTRACT. The effects of acepromazine-butorphanol (AB), midazolam-butorphanol (MB) and medetomidine (Med) on the induction dose of propofol and their compatibility with propofol were evaluated in client-owned dogs. All premedications induced good to excellent sedation and the induction dose of propofol was considerably reduced. Of the tested premedicants, Med induced the deepest sedation and the most potent dose-sparing effect. Induction of anesthesia was excellent to good in all dogs except for one dog premedica ted with MB. Most dogs premedicated with AB or MB showed temporary apnea. Although other adverse effects such as bradycardia or hypotension may also occur, premedication with MB, AB or Med is a valuable technique for the induction of anesthesia with propofol in dogs in a clinical setting. KEY WORDS: canine, premedication, propofol.J. Vet. Med. Sci. 65(10): 1141-1143, 2003 Propofol is an intravenous anesthetic which has highly desirable characteristics such as rapid onset of anesthesia, short duration of action, lack of accumulation upon repeated administration and lack of excitatory effects on induction [1,16]. Because of these beneficial characteristics, propofol is now accepted as a useful agent in dogs. In veterinary anesthesia, preanesthetic medications such as tranquilizers, sedatives and analgesics are commonly used for the safe and smooth induction of anesthesia. The preanesthetic use of drugs has been shown to have a sparing effect on the induction dose of intravenous anesthetics [4,10,11]. Preanesthetic medication has also been reported to modify the cardiovascular effects induced by induction agents. The purpose of this study was to evaluate the effects of acepromazine-butorphanol, midazolam-butorphanol and medetomidine on the dose of propofol needed to induce anesthesia in dogs, and to examine the compatibility of these preanesthetics with propofol in clinical cases.Eighty client-owned dogs were evaluated in this study. These patients were admitted to the Veterinary Medical Center of the University of Tokyo from April of 2000 to July of 2001 for a variety of surgeries or treatments. Their age, body weight, gender, the type of surgery or treatment and the combination of premedicants used before anesthesia are shown in Table 1, which also includes the physical status of each animal before anesthesia based on the American Society of Anesthesiologists (ASA) standards [6,12]. The heart rate (HR) and arterial blood pressure (BP) were monitored non-invasively by a multifunction monitor (Multifunction monitor COLIN BP-58 , Nihon Colin Co. , Tokyo , Japan).The following drugs were used for preanesthetic medication: intramuscular medetomidine (Med; Domitor, Meijiseika Co., Tokyo , Japan) at a dose of 1,000 µg/m 2 , intravenous midazolam (Dormicum , Yamanouchi Pharmaceutical Co., Tokyo , Japan) and butorphanol (Stadol, Bristol -Myers Squibb Co., Tokyo , Japan) (MB) at doses of 0.1 and 0.2 mg/kg, respectively, and intramuscular acepromazine (Prom Ace, Fort Dodge Laboratories Inc., Iowa , U.S.A.) and buto...

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confidence: 99%

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confidence: 99%

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Effects of Midazolam-Butorphanol, Acepromazine-Butorphanol and Medetomidine on an Induction dose of Propofol and Their Compatibility in Dogs

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“…Conforme relatado por Souza et al (2003), não ficou evidenciada no presente experimento a apneia durante e após a indução, o que é considerado um inconveniente do propofol em gatos (Brearley et al, 1988;Morgan & Legge, 1989;Andress et al, 1995;Sano et al, 2003). Durante a indução, da mesma forma que o observado por Souza et al (2002) e Souza et al (2003), foram evidenciadas manifestações de dor à injeção ou contrações musculares.…”

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Anestesia por infusão contínua de propofol associado ao remifentanil em gatos pré-tratados com acepromazina

Mata¹,

Pompermayer²,

Favarato³

et al. 2010

Rev. Ceres

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Anesthesia by continuous infusion of propofol with remifentanil in cats pretreated with acepromazineThe present work evaluated the anesthetic association of propofol, an ultra-short acting general anesthetic with a fast metabolism, with remifentanil, an opioid of great analgesic potency that is used as adjunct to general anesthetics. The main objective was to develop a safe protocol of intravenous continuous infusion capable of providing comfort for the patient with great analgesic action and muscle relaxation for cats subjected to elective surgeries like ovariohysterectomy and orchiectomy. Thirty cats were randomly distributed in 3 groups of 10 animals each. All animals were tranquilized with acepromazine (0.1 mg/kg IM) and general anesthesia was induced using propofol (6mg/kg, IV). In group 1, general anesthesia was maintained by continuous infusion of propofol (0.6 mg/kg/min); in group 2, with propofol (0.4 mg/kg/min) and remifentanil (0.1 µg/kg/min) and; in group 3, with propofol (0.4 mg/kg/min) and remifentanilRecebido para publicação em dezembro de 2007 e aprovado em soutubro de 2010

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Preanesthesia, Anesthesia, Chemical Restraint, and the Recognition and Treatment of Pain and Distress

Gross

2009

Animal Models in Cardiovascular Research

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Clinical Usefulness of Propofol as an Anesthetic Induction Agent in Dogs and Cats

Cited by 34 publications

References 24 publications

Effects of Midazolam-Butorphanol, Acepromazine-Butorphanol and Medetomidine on an Induction dose of Propofol and Their Compatibility in Dogs

Effects of Midazolam-Butorphanol, Acepromazine-Butorphanol and Medetomidine on an Induction dose of Propofol and Their Compatibility in Dogs

Anestesia por infusão contínua de propofol associado ao remifentanil em gatos pré-tratados com acepromazina

Preanesthesia, Anesthesia, Chemical Restraint, and the Recognition and Treatment of Pain and Distress

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