Clinical Uses of Platelet-Rich Fibrin in Oral and Maxillofacial Surgery

Fan, Yijiao; Perez, Karla Joseane; Dym, Harry

doi:10.1016/j.cden.2019.12.012

Cited by 75 publications

(74 citation statements)

References 24 publications

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“…Different bioactive agents have been used including; hyaluronic acid, fibrin sealants, platelet rich plasma, pentoxifylline, fibroblast growth factors etc 5 - 7 . PRF (platelet rich fibrin) is basically plasma enriched with higher concentration of autologous human platelets 8 . Degradation of granules within the PRF and release of growth factors is the basic mechanism of enhanced healing.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Platelet Rich Fibrin in Myringoplasty

2020

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Objective: To determine the efficacy of usage of topical autologous platelet rich fibrin (PRF) in improving outcomes of myringoplasty regarding graft uptake and hearing improvement. Methods: This study was conducted in the ENT department of Holy Family Hospital, Rawalpindi, over a period of six months from August 2019 to January 2020. It was designed as a prospective single blinded randomized controlled trial. The study involved a total of 50 participants in whom myringoplasty was done through post auricular approach using underlay technique. In 25 patients topical drops of PRF were used. Outcomes were compared after three months with the control group (n=25), who underwent myringoplasty without PRF. Results: After three months follow-up, graft uptake was reported 78% and 52% in cases and controls, respectively (P=0.070). Mean hearing improvement was 18 dB and 6 dB in cases and controls, respectively (P=0.014). Postoperative infection occurred in 8% of the cases, and in 32% controls (P=0.037). Conclusion: Topical use of Platelet-Rich Fibrin during myringoplasty results in improved graft uptake. Hence, resulting in much improved hearing, significant reduction in infection rates and decrease in perforation sizes. doi: https://doi.org/10.12669/pjms.37.1.3059 How to cite this:Riaz N, Ajmal M, Khan MS. Efficacy of Platelet Rich Fibrin in Myringoplasty. Pak J Med Sci. 2021;37(1):212-216. doi: https://doi.org/10.12669/pjms.37.1.3059 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Introductionmentioning

confidence: 99%

Efficacy of Platelet Rich Fibrin in Myringoplasty

2020

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“…There are several different uses of platelet concentrates in dentistry, including: endodontic treatment of permanent teeth with incomplete apex development (pulpotomy, revascularization and apexification), guided bone regeneration (alveolar bone augmentation, sinus lifting), periodontal treatment (plastic periodontology surgery, treatment of bone loss defects). Moreover, the use of PRF in guided tissue regeneration scaffold has been the subject of extended investigations [110][111][112][113][114][115].…”

Section: Platelet Concentrates-general Characteristics and Role In The Endodontic Treatmentmentioning

confidence: 99%

Plasma Rich in Growth Factors in the Treatment of Endodontic Periapical Lesions in Adult Patients: A Narrative Review

et al. 2021

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Platelet concentrates have been widely used in regenerative medicine, including endodontics. The aim of this manuscript was to assess critically the efficacy of PRF in the treatment of endodontic periapical lesions in adult patients on the basis of the literature. The PICO approach was used to properly develop literature search strategies. The PubMed database was analyzed with the keywords: “((PRP) OR (PRF) OR (PRGF) OR (CGF)) AND (endodontic) AND ((treatment) OR (therapy))”. After screening of 155 results, 14 articles were included in this review. Different types of platelet concentrates are able to stimulate the processes of proliferation and differentiation of mesenchymal stem cells. Platelet rich fibrin (PRF) releases growth factors for at least 7 days at the application site. Growth factors and released cytokines stimulate the activity of osteoblasts. Moreover, the release of growth factors accelerates tissue regeneration by increasing the migration of fibroblasts. It was not possible to assess the efficacy of PRF supplementation in the treatment of endodontic periapical lesions in permanent, mature teeth with closed apexes, due to the lack of well-designed scientific research. Further studies are needed to analyze the effect of PRF on the healing processes in the periapical region.

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“…Ulcer is greatly challenging to the skin specialists while dealing with diabetic senior patients and in Hansen disease. PRFM is extensively used in regenerative medicine, in maxillofacial surgeries for rejuvenation of periodontal tissue and as implants, in dentistry [39,40]. The matrix generated is set as a biological dressing after debriding the wound tissue [41].…”

Section: Fractions Of Prpmentioning

confidence: 99%

Aesthetics in Geriatrics Using Plasma and Its Fractions in India

Kachhawa¹,

Narasimha²

2021

J Clin Epid Toxic

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Introduction: Geriatric aesthetics is an evolving branch of cosmetology with extensive research conducted to minimize the invasiveness, number of visits and safety of the proposed modality. In developing country, the adding burden of cost hinders the practical application of standard aesthetic procedures used elsewhere. Platelet-rich plasma is an autologous preparation that is utilized in various fields of regenerative medicine.

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Clinical Uses of Platelet-Rich Fibrin in Oral and Maxillofacial Surgery

Cited by 75 publications

References 24 publications

Efficacy of Platelet Rich Fibrin in Myringoplasty

Efficacy of Platelet Rich Fibrin in Myringoplasty

Plasma Rich in Growth Factors in the Treatment of Endodontic Periapical Lesions in Adult Patients: A Narrative Review

Aesthetics in Geriatrics Using Plasma and Its Fractions in India

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