Clinical utility and interobserver agreement of autofluorescence imaging and magnification narrow-band imaging for the evaluation of Barrett's esophagus: a prospective tandem study

Giacchino, Maria; Bansal, Ajay; Kim, Raymond E.; Singh, Vikas; Hall, Sandy B.; Singh, Mandeep; Rastogi, Amit; Moloney, Brian; Wani, Sachin; Gaddam, Srinivas; Mathur, Sharad C.; Wallace, Michael B.; Kanakadandi, Vijay; Balasubramanian, Gokulakrishnan; Gupta, Neil; Sharma, Prateek

doi:10.1016/j.gie.2013.01.029

Cited by 32 publications

(21 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…37 However, AFI has high-false positive rate of 86%, and its clinical use remains unclear. 38 A meta-analysis of five prospective studies totalling 371 patients showed that AFI offers ∼2% improvement over WLE for detecting Barrett's neoplasia. 39 AFI may be clinically useful in high-risk patients after either ablation or surgical resection to assess for residual disease.…”

Section: Advances In Wide-field Endoscopymentioning

confidence: 99%

Emerging optical methods for surveillance of Barrett's oesophagus

Sturm

Wang

2015

Gut

View full text Add to dashboard Cite

The rapid rise in incidence of oesophageal adenocarcinoma has motivated the need for improved methods for surveillance of Barrett’s oesophagus. Early neoplasia is flat in morphology and patchy in distribution and is difficult to detect with conventional white light endoscopy (WLE). Light offers numerous advantages for rapidly visualising the oesophagus, and advanced optical methods are being developed for wide-field and cross-sectional imaging to guide tissue biopsy and stage early neoplasia, respectively. We review key features of these promising methods and address their potential to improve detection of Barrett’s neoplasia. The clinical performance of key advanced imaging technologies is reviewed, including (1) wide-field methods, such as high-definition WLE, chromoendoscopy, narrow-band imaging, autofluorescence and trimodal imaging and (2) cross-sectional techniques, such as optical coherence tomography, optical frequency domain imaging and confocal laser endomicroscopy. Some of these instruments are being adapted for molecular imaging to detect specific biological targets that are overexpressed in Barrett’s neoplasia. Gene expression profiles are being used to identify early targets that appear before morphological changes can be visualised with white light. These targets are detected in vivo using exogenous probes, such as lectins, peptides, antibodies, affibodies and activatable enzymes that are labelled with fluorescence dyes to produce high contrast images. This emerging approach has potential to provide a ‘red flag’ to identify regions of premalignant mucosa, outline disease margins and guide therapy based on the underlying molecular mechanisms of cancer progression.

show abstract

Section: Advances In Wide-field Endoscopymentioning

confidence: 99%

Emerging optical methods for surveillance of Barrett's oesophagus

Sturm

Wang

2015

Gut

View full text Add to dashboard Cite

show abstract

“…(67) (Figure 4) While this technique has shown in studies a high sensitivity for the detection of HGD, specificity was poor with false positive rates up to 81%. (22,(68)(69)(70) In a prospective multi-center study with 84 patients significant reduction of false positives was demonstrated a when integrating NBI and AFI to a HRE in a trimodal prototype(71) AFI identified all 16 patients with early neoplasia identified with HRE and detected an additional 11 patients with early neoplasia that were not identified with HRE. After HRE inspection, AFI detected an additional 102 lesions; 19 contained HGIN/EC (thus a false positive rate of AFI after HRE: 81%).…”

Section: Autofluorescencementioning

confidence: 99%

Red flag imaging in Barrett's esophagus: Does it help to find the needle in the haystack?

González-Haba

Waxman

2015

Best Practice & Research Clinical Gastroenterology

View full text Add to dashboard Cite

“…Additional wide-field imaging techniques, such as narrowband imaging (NBI) 15 and autofluorescence imaging (AFI), 16 have undergone more extensive clinical evaluation. However, recent studies suggest that NBI and AFI have insufficient clinical accuracy 17 and that AFI has a limited role in diagnostic and therapeutic decision making in routine surveillance and management of patients with BE, 18 in part since inflammatory changes can mimic neoplasia during AFI.…”

Section: Introductionmentioning

confidence: 99%

Quantitative evaluation ofin vivovital-dye fluorescence endoscopic imaging for the detection of Barrett’s-associated neoplasia

et al. 2015

View full text Add to dashboard Cite

Abstract. Current imaging tools are associated with inconsistent sensitivity and specificity for detection of Barrett's-associated neoplasia. Optical imaging has shown promise in improving the classification of neoplasia in vivo. The goal of this pilot study was to evaluate whether in vivo vital dye fluorescence imaging (VFI) has the potential to improve the accuracy of early-detection of Barrett's-associated neoplasia. In vivo endoscopic VFI images were collected from 65 sites in 14 patients with confirmed Barrett's esophagus (BE), dysplasia, or esophageal adenocarcinoma using a modular video endoscope and a high-resolution microendoscope (HRME). Qualitative image features were compared to histology; VFI and HRME images show changes in glandular structure associated with neoplastic progression. Quantitative image features in VFI images were identified for objective image classification of metaplasia and neoplasia, and a diagnostic algorithm was developed using leave-one-out cross validation. Three image features extracted from VFI images were used to classify tissue as neoplastic or not with a sensitivity of 87.8% and a specificity of 77.6% (AUC ¼ 0.878). A multimodal approach incorporating VFI and HRME imaging can delineate epithelial changes present in Barrett's-associated neoplasia. Quantitative analysis of VFI images may provide a means for objective interpretation of BE during surveillance. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

show abstract

Clinical utility and interobserver agreement of autofluorescence imaging and magnification narrow-band imaging for the evaluation of Barrett's esophagus: a prospective tandem study

Abstract: By using a multimodality endoscope, both AFI and magnification NBI had limited clinical accuracy and moderate overall interobserver agreement. AFI does not appear to be useful as a broad-based technique for the detection of neoplasia in patients with BE.

Cited by 32 publications

References 17 publications

Emerging optical methods for surveillance of Barrett's oesophagus

Emerging optical methods for surveillance of Barrett's oesophagus

Red flag imaging in Barrett's esophagus: Does it help to find the needle in the haystack?

Quantitative evaluation ofin vivovital-dye fluorescence endoscopic imaging for the detection of Barrett’s-associated neoplasia

Contact Info

Product

Resources

About