Clinical utility of cytomegalovirus urine cultures for ophthalmic care in patients with HIV.

Gellrich, M M; Baumert, E.; Rump, J. A.; Vaith, P; Hufert, Frank T.; Hansen, Lena

doi:10.1136/bjo.80.9.818

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…Another study suggested ophthalmic screening in HIV patients with CMV present in urinalysis or "CMVuria"; CMVuria as a single finding, however, does not justify antiviral prophylaxis against CMVR [105]. CMV antigenemia testing may be a valuable tool for the rapid diagnosis of CMV disease in HIV-infected individuals, but these results need to be interpreted in the context of the clinical presentation and ophthalmic findings [103,106].…”

Section: Isolation Of CMV From Blood Leukocytes Can Provide Insight Imentioning

confidence: 99%

Cytomegalovirus Retinitis in HIV and Non-HIV Individuals

et al. 2019

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Cytomegalovirus retinitis (CMVR) is a severe, vision-threatening disease that primarily affects immunosuppressed patients. CMVR is the most common ocular opportunistic infection in human immunodeficiency virus (HIV) infected patients and is the leading cause of blindness in this group; however, the incidence of CMVR in HIV patients has dramatically decreased with antiretroviral therapy. Other causes of immunosuppression, including organ transplantation, hematologic malignancies, and iatrogenic immunosuppression, can also lead to the development of CMVR. Herein, we describe the pathogenesis of CMVR and compare clinical features, epidemiology, and risk factors in HIV and non-HIV infected individuals with CMVR.

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Section: Isolation Of CMV From Blood Leukocytes Can Provide Insight Imentioning

confidence: 99%

Cytomegalovirus Retinitis in HIV and Non-HIV Individuals

et al. 2019

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“…Virurie. Bezuglich positiver CMV-VirusKulturen konnte jedoch gezeigt werden, daB viramische Episoden nur geringfugig mit dem tatsachlichen Vorliegen einer Endorganmanifestation am Auge korrelieren [23,56]. Die aktuellsten diagnostischen Entwicklungen konzentrieren sich daher auf eine Erfassung der Cytomegalie-Virusbelastung im peripheren Blut mittels quantitativer PCR [25].…”

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Der HIV-positive Patient

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Krepler

et al. 1999

Spektrum Augeheilkd

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“…This risk rises to 38% when the CD4+ Tlymphocyte count is less than 50 cells/ml and accompanied by CMV uria. It has been suggested that these patients be screened every 6 weeks 6 .…”

Section: Introductionmentioning

confidence: 99%

Monitoring Cytomegalovirus Retinitis Prevalence in an HIV-Seropositive Cohort: The Assessment of Improvements Observed following the Introduction of Highly Active Antiretroviral Triple Therapy

et al. 1999

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This paper concerns the ophthalmic assessment of patients with acquired immunodeficiency syndrome (AIDS) for a number of eye conditions and in particular cytomegalovirus (CMV) retinitis. CMV has been the most common opportunistic infection associated with AIDS and the leading cause of blindness among AIDS patients. There have been early indications of a widespread fall in CMV prevalence internationally following the introduction of a new highly active antiretroviral triple (HAART) therapy. Our study sought to assess the position for Ireland. Our cohort was the entire population of stage IV AIDS patients attending the country's leading referral centre. The total number of patients examined was 167 and the period of examination was 1 May 1995 to 30 April 1997. HAART was introduced in March 1996, so the data permitted a 'before and after' comparison of various clinical findings. The incidence of new CMV cases was found to be 4 among the 102 patients examined in the first 12-month period and one among 107 patients examined in the second 12-month period. There were accompanying declines in HIV-related noninfectious retinal vasculopathy (HIVR), keratitis and other conditions. The findings are promising, but we argue that caution is needed in assessing long-term trends. In the paper we discuss a number of methodological issues in the collection and analysis of the clinical data and in the interpretation of results.

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Clinical utility of cytomegalovirus urine cultures for ophthalmic care in patients with HIV.

Cited by 5 publications

References 22 publications

Cytomegalovirus Retinitis in HIV and Non-HIV Individuals

Cytomegalovirus Retinitis in HIV and Non-HIV Individuals

Der HIV-positive Patient

Monitoring Cytomegalovirus Retinitis Prevalence in an HIV-Seropositive Cohort: The Assessment of Improvements Observed following the Introduction of Highly Active Antiretroviral Triple Therapy

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