Clinical utility of landiolol for use in coronary CT angiography

Tomizawa, Nobuo; Hayakawa, Yasushi; Inoh, Shinichi; Nojo, Takeshi; Nakamura, Sunao

doi:10.2147/rrcc.s77559

Cited by 8 publications

(5 citation statements)

References 81 publications

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“…Oral β-blocker (metoprolol, 20 or 40 mg) was used 1 h before the exam to achieve the target heart rate of 65 beats per minute. A maximum dose of 12.5 mg of landiolol (Corebeta; Ono Parmaceutical) was given intravenously if the heart rate was > 65 bpm at the CT room [ 18 ]. All patients received 0.6 mg of sublingual nitroglycerin (Nitropen; Nippon Kayaku) before imaging.…”

Section: Methodsmentioning

confidence: 99%

Energy loss is related to CT fractional flow reserve progression in type 2 diabetes mellitus patients

Tomizawa,

Fujimoto,

Takahashi

et al. 2023

American Heart Journal Plus: Cardiology Research and Practice

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Section: Methodsmentioning

confidence: 99%

Energy loss is related to CT fractional flow reserve progression in type 2 diabetes mellitus patients

Tomizawa,

Fujimoto,

Takahashi

et al. 2023

American Heart Journal Plus: Cardiology Research and Practice

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“…The scan started 6 s after the descending aorta reached 60 Hounsfield units (HU) above the initial value. If the heart rate was over 65 beats/min, a maximum dose of 12.5 mg of landiolol (Corebeta; Ono Pharmaceutical, Tokyo, Japan) was given intravenously 11 . No side-effects were reported using beta-blockers including vasospasm.…”

Section: Patients a Total Of 286 Patients Between April 2016 And Octmentioning

confidence: 99%

Impact of Abnormal Remote Stress Myocardial Blood Flow by Dynamic CT Perfusion on Clinical Outcomes

Tomizawa

Chou

Fujino

et al. 2020

Sci Rep

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The objective of this study was to investigate the incremental prognostic value for adverse events of myocardial blood flow (MBF) derived from stress computed tomography perfusion (CTP) at remote myocardium over cardiac risk factors and ischemia. We prospectively analyzed 242 patients who underwent dynamic CTP and CT angiography. Adverse events were defined as a composite of all-cause mortality, non-fatal myocardial infarction, unstable angina, heart failure requiring hospitalization, peripheral artery disease, and stroke. MBF value was calculated in each myocardial segment and ischemia was defined as mild decrease in MBF in two consecutive segments or moderate decrease in a single segment accompanied with a coronary stenosis ≥50%. The mean MBF of the non-ischemic segments was defined as remote MBF. We divided the patients into two groups by median MBF value of 1.15 ml/min/g. During a median follow-up of 18 months, 18 patients had adverse events. Annual event rate showed a significant difference between patients with low (≤1.15 ml/min/g) and high (>1.15 ml/min/g) MBF (6.1% vs 1.8%, p = 0.02). Univariate analysis showed that low MBF was a significant predictor of events (hazard ratio (HR): 3.4; 95% confidence interval (CI): 1.2 to 12.0; p = 0.02). This relationship maintained significant after adjusted for the presence of ischemia and cardiac risk factors (HR: 3.0; 95%CI: 1.1 to 11.1; p = 0.04). In conclusion, MBF value ≤1.15 ml/min/g derived from dynamic CTP in remote myocardium is significantly related with poor outcome and this relationship was independent of myocardial ischemia and cardiac risk factors.

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“…Patients with heart rate > 65 beats/min at the outpatient department were told to take an oral β-blocker (20 mg of metoprolol) 1 h prior to CT angiography. If the heart rate was over 65 beats/min on site, a maximum dose of 12.5 mg of landiolol (Corebeta; Ono Pharmaceutical, Tokyo, Japan) was given intravenously [5]. All patients received 0.3 mg sublingual nitroglycerin (Nitropen; Nippon Kayaku, Tokyo, Japan) before imaging.…”

Section: Patientsmentioning

confidence: 99%

Simplified Bernoulli Formula to Diagnose Ischemia-Causing Stenosis at Coronary CT Angiography: Comparison with SPECT

Tomizawa¹,

Arakawa²,

Yamamoto³

et al. 2019

ACT

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Purpose: To compare the diagnostic performance of estimated energy loss (EEL) calculated using a simplified Bernoulli formula at coronary computed tomography (CT) and single photon emission computed tomography (SPECT) to diagnose ischemia-causing stenosis by invasive fractional flow reserve (FFR). Methods: We retrospectively included 43 patients who underwent coronary CT, SPECT, and FFR measurement by catheter within 3 months. When an intermediate stenosis (40% -70%) was present at CT, EEL was calculated using the following parameters: lesion length, diameter stenosis, minimal lumen area, and the myocardial volume. An EEL > 1.17 or diameter stenosis > 70% was determined ischemic. Stress-induced ischemia by SPECT was determined when a perfusion defect at stress was accompanied with a fill-in at rest. An FFR ≤ 0.80 or diameter stenosis >70 % was determined as ischemic by catheter. Results: A total of 26 vessels were determined as ischemic by catheter exam. The per-vessel sensitivity and specificity of EEL and SPECT were 81% vs 42% and 92% vs 91%, respectively. The accuracy of EEL to diagnose stenosis causing ischemia was significantly higher than SPECT (90% vs 81%, p = 0.04). The area under the curve of the receiver operating characteristics curve was also significantly higher for EEL than SPECT (0.86 vs 0.67, p < 0.005). Conclusions: EEL showed higher accuracy than SPECT to diagnose ischemia-causing stenosis by improving the sensitivity.

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Clinical utility of landiolol for use in coronary CT angiography

Cited by 8 publications

References 81 publications

Energy loss is related to CT fractional flow reserve progression in type 2 diabetes mellitus patients

Energy loss is related to CT fractional flow reserve progression in type 2 diabetes mellitus patients

Impact of Abnormal Remote Stress Myocardial Blood Flow by Dynamic CT Perfusion on Clinical Outcomes

Simplified Bernoulli Formula to Diagnose Ischemia-Causing Stenosis at Coronary CT Angiography: Comparison with SPECT

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