Clinical utility of MRI and SPECT in the diagnosis of cognitive impairment referred to memory clinic

Guinane, John; Ng, Boon Lung

doi:10.1017/s1041610217001624

Cited by 3 publications

(4 citation statements)

References 14 publications

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“…This finding is consistent of our previous hypothesis that the FC integrity between the HIP and other brain regions may have potential as an early diagnostic tool in identifying the effect of cognitive training when in large samples. The clinical utility of MRI scanning has been broadly superior to the available international evidence in identifying positive outcomes or brain activation (Guinane and Ng, 2018; Tibon et al ., 2019).…”

Section: Discussionmentioning

confidence: 99%

The effect of creative expression program in neurocognitive networks performance measured by task and resting-state functional MRI

Zhao

Cai

et al. 2023

International Psychogeriatrics

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Background: The current study examined the effects of a 16-week creative expression program on brain activity during a story creating task and resting-state functional network connectivity in mild cognitive impairment (MCI) adults. Method: Thirty-six MCI adults were allocated to either the creative expression program (CrExp, n = 18) or control group (CG,n = 18). Before and after intervention, all participants were scanned with functional magnetic resonance imaging (fMRI) during story creating task performance and a resting state. The two-group comparison was calculated between the blood oxygenation level-dependent (BOLD) signal changes for each cluster to investigate the differences in fMRI activation and functional connectivity (FC) between two groups. Results: Task activation analyses showed an increase in the right anterior cingulate gyrus (ACG), right medial frontal gyrus (MFG), right lentiform nucleus (LN), left hippocampus (HIP), left middle occipital gyrus (MOG), and left cerebellum posterior lobe (CPL) (p < 0.05). Story creating performance improvements were associated with greater activation in the left HIP region. Resting-state functional connectivity (FC) between left HIP and certain other brain areas shown a significant interaction of creative expression group versus control group. Moreover, connectivity between the right angular gyrus (ANG), right inferior temporal gyrus (ITG), right superior occipital gyrus (SOG), left ANG, and left MFG were related to improved cognitive performance (p < 0.05). Conclusion: These data extend current knowledge by indicating that the creative expression program can improve cognitive activation in MCI, and these enhancements may be related to the neurocognitive network plasticity changes induced by creative expression training.

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Section: Discussionmentioning

confidence: 99%

The effect of creative expression program in neurocognitive networks performance measured by task and resting-state functional MRI

Zhao

Cai

et al. 2023

International Psychogeriatrics

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“…The historic underutilization of neuroimaging techniques in psychiatry has also led to the consequential inadequate biological understanding of neuropsychiatric conditions ( 26 ). Without such biological understanding it is also difficult to identify meaningful biomarkers for diagnosis, prognosis or risk, which is particularly relevant as psychiatric treatments can lead to biological changes ( 24 , 26 , 27 ). In addition, neuropsychiatric conditions are often diagnosed using a process of exclusion and additional information from brain SPECT imaging can complement the information gathered from clinical assessments.…”

Section: Introductionmentioning

confidence: 99%

“…However, SPECT imaging is underutilized in clinical practice despite a growing, evidence-based foundation for its application in numerous indications relevant to psychiatric practice (14)(15)(16)(17)(18)(19)(20)(21)(22)(23). This underutilization is particularly unfortunate as SPECT is an easy-to-perform, non-invasive procedure and remains among the least expensive neuroimaging tools available (24,25). The historic underutilization of neuroimaging techniques in psychiatry has also led to the consequential inadequate biological understanding of neuropsychiatric conditions (26).…”

Section: Introductionmentioning

confidence: 99%

Brain SPECT as an Imaging Biomarker for Evaluating Effects of Novel Treatments in Psychiatry–A Case Series

2022

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The difficulties of evaluating patients with complex neuropsychiatric conditions and prescribing appropriate treatments are well known. Imaging complements clinical assessments and allows a clinician to narrow the differential diagnosis by facilitating accurate and efficient evaluation. This is particularly relevant to neuropsychiatric conditions that are often diagnosed using a trial-and error process of exclusion. Single Photon Emission Computed Tomography (SPECT) is a functional brain imaging procedure that allows practitioners to measure the functional changes of gray matter structures based on regional cerebral blood flow (rCBF). The accurate diagnosis and treatment selection in psychiatry is challenging due to complex cases and frequent comorbidities. However, such complex neuropsychiatric conditions are increasingly benefitting from new treatment approaches, in addition to established medications. Among these are combination transcranial magnetic stimulation with ketamine infusions (CTK), hyperbaric oxygen therapy (HBOT) and perispinal administration of etanercept (PSE). This article provides readers with six case study examples that demonstrate how brain SPECT imaging can be used, both as a diagnostic tool, and as a potential biomarker for monitoring and evaluating novel treatments for patients with complex neuropsychiatric conditions. Six patients were assessed in our clinic and baseline brain SPECT imagesTourettes and a long history of alcohol were visually compared with SPECT images collected after periods of treatment with CTK or HBOT followed by PSE. This retrospective review demonstrates the clinical utility of these novel treatments and describes how SPECT imaging can complement standard diagnostic assessments. A novel display technique for SPECT images is described and we argue that SPECT imaging can be used for monitoring biomarker for clinical change.

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“…In an investigation addressing the important health economics question about the best use of limited healthcare resources and the value of additional neuroimaging to provide clinically meaning information, Guinane and Ng (2017) recruited a convenience sample from their memory clinic. Specifically, they explored the beneficial role of additional MRI and/or SPECT brain imaging to routine diagnostic workup to improve diagnostic accuracy in a memory assessment encompassing a non-contrast CT brain.…”

mentioning

confidence: 99%

Translating progress in neuroimaging into clinical practice

Durcan

Thomas

2018

Int. Psychogeriatr.

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Neuroimaging continues to be an exciting and rapidly evolving research field producing findings to inform clinical medical practice. Neuroimaging research has enabled a better understanding of in vivo structural, functional, and molecular neuropathology. Moreover, it has the potential to improve clinical care, where clinical assessment alone is sometimes insufficient to provide accurate diagnosis and prognosis. The future direction of neuroimaging is likely to focus on identifying imaging biomarkers suggestive of underlying preclinical disease, understanding the temporal progression from preclinical disease to overt clinical manifestation, and monitoring the therapeutic efficacy of potential disease-modifying agents.

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Clinical utility of MRI and SPECT in the diagnosis of cognitive impairment referred to memory clinic

Abstract: The clinical utility of MRI and/or SPECT scanning in this study may be broadly superior to the available international evidence, and further research is needed to identify predictors of positive scan outcomes.

Cited by 3 publications

References 14 publications

The effect of creative expression program in neurocognitive networks performance measured by task and resting-state functional MRI

The effect of creative expression program in neurocognitive networks performance measured by task and resting-state functional MRI

Brain SPECT as an Imaging Biomarker for Evaluating Effects of Novel Treatments in Psychiatry–A Case Series

Translating progress in neuroimaging into clinical practice

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