Clinical utility of the MAFLD definition

Zheng, Kenneth I.; Sun, Dan‐Qin; Jin, Yi; Zhu, Pei-Wu; Zheng, Ming‐Hua

doi:10.1016/j.jhep.2020.12.016

Cited by 55 publications

(50 citation statements)

References 10 publications

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“…The effectiveness of MAFLD diagnostic criteria in selecting adult patients with fatty liver disease associated with metabolic dysfunction is still debating [12][13][14]21,22].…”

Section: Discussionmentioning

confidence: 99%

MAFLD in Obese Children: A Challenging Definition

Sessa¹,

Guarino²,

Umano³

et al. 2021

Children

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Background: Recently, the new definition of Metabolic (dysfunction) associated fatty liver disease (MAFLD) has gained remarkable scientific interest. We aimed to evaluate the effectiveness of MAFLD definition in selecting obese children at higher cardiovascular risk. Methods: A total of 954 obese children and adolescents was retrospectively enrolled. Clinical, biochemical, and metabolic evaluations were performed. Hepatic steatosis was assessed by liver ultrasound. According to the metabolic status, the population was divided in three groups. Group 1 included obese patients without both non-alcoholic fatty liver disease (NAFLD) and metabolic dysregulation; group 2 included patients with obesity and NAFLD (then encompassing one MAFLD criterion); group 3 included patients with obesity, NAFLD and evidence of metabolic dysregulation (then encompassing more than 1 MAFLD criteria). Results: Patients of Group 3 showed a worse cardiometabolic profile, as also proven by the higher percentage of prediabetes (defined as the presence of impaired fasting glucose or impaired glucose tolerance) compared to other groups (p = 0.001). Conclusions: MAFLD criteria in obese children seem to be less accurate in identifying patients having an intrinsic higher cardiometabolic risk. This suggests the need for a more accurate definition in the context of pediatric obesity.

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“…The effectiveness of MAFLD diagnostic criteria in selecting adult patients with fatty liver disease associated with metabolic dysfunction is still debating [12][13][14]21,22].…”

Section: Discussionmentioning

confidence: 99%

MAFLD in Obese Children: A Challenging Definition

Sessa¹,

Guarino²,

Umano³

et al. 2021

Children

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show abstract

“…In a recent study by Zheng et al, focused on the PERSONS cohort, 9 of the 780 consecutively enrolled subjects with liver biopsy, 663 (85%) fulfilled both the "NAFLD" and "MAFLD" criteria. 10 The difference in the number between the two groups (670 NAFLD vs. 773 MAFLD) was due to 7 patients with FLD who were lean by body mass index (BMI) without satisfying the metabolic risk threshold (defined as Non-metabolic risk NAFLD, Non-MR NAFLD), and the inclusion of 110 patients with FLD and other etiologies of liver diseases (66 with excess alcohol consumption, 40 with viral hepatitis, and 4 with autoimmune hepatitis). Notably, Age, sex, comorbid diseases (i.e., diabetes mellitus and hypertension), variant distribution of the PNPLA3 gene, metabolic profile, and histology including liver steatosis and fibrosis were not significantly different between the two groups.…”

Section: Added Populations According To Mafld Criteriamentioning

confidence: 99%

From nonalcoholic fatty liver disease to metabolic-associated fatty liver disease: Big wave or ripple?

et al. 2021

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“…However, some studies do not report this finding; one study (7) of 1,710 persons from the general population found that advanced liver fibrosis (defined as a median liver stiffness ≥9.7 KPa) was not different in MAFLD and NAFLD groups. Another study (8) of a population of 780 with liver biopsy reported that both groups have similar clinical characteristics and liver histology. Likewise, a cohort study (4) with a 7-year follow-up of ~900 patients showed that MAFLD and NAFLD groups had similar new-onset cardiovascular events.…”

mentioning

confidence: 94%