Clinical utility of the Wechsler Memory Scale—Fourth Edition (WMS-IV) in predicting laterality of temporal lobe epilepsy among surgical candidates

Soble, Jason R.; Eichstaedt, Katie E.; Waseem, Hena; Mattingly, Michelle; Benbadis, Selim R.; Bozorg, Ali; Vale, Fernando Ĺ.; Schoenberg, Mike R.

doi:10.1016/j.yebeh.2014.10.014

Cited by 18 publications

(7 citation statements)

References 26 publications

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“…Specifically, the tests derived from the Wechsler scales appear relevant and valid in these patients who may present subtle cognitive disorders (as mentioned in the Introduction; see also Table S1 for the average z scores), difficult to estimate with less sophisticated and comprehensive testing. We previously reported their clinical efficiency in a study aiming to lateralize epilepsy in drug-resistant patients [29] and the robustness of the WMS compared with other tests has also been highlighted by other studies in patients with epilepsy [70]. Furthermore, these neuropsychological indices are associated with the functional disturbances in resting-state brain connectivity exhibited by patients with TLE [11], confirming their clinical efficiency and potentially explaining why they are selected as good predictors of postsurgical status after temporal lobectomy.…”

Section: Discussionsupporting

confidence: 52%

Prediction of the clinical and naming status after anterior temporal lobe resection in patients with epilepsy

Roger

Torlay

Banjac

et al. 2021

Epilepsy & Behavior

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Section: Discussionsupporting

confidence: 52%

Prediction of the clinical and naming status after anterior temporal lobe resection in patients with epilepsy

Roger

Torlay

Banjac

et al. 2021

Epilepsy & Behavior

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“…The Wechsler Memory Scale is one of the most commonly used memory tests in patients with epilepsy, and is often a part of standard pre-surgical evaluation. Patients with temporal lobe epilepsy have been found to have lower scores when compared to healthy controls, but the tests on their own have been unable to lateralize temporal epilepsy successfully [ 70 , 71 ]. We found that local increase in connectivity of the dynamically constrained cluster in patients correlated negatively with scores on the Logical Memory Delayed Recall task suggesting, as expected, that more severe symptoms were associated with higher local connectivity.…”

Section: Discussionmentioning

confidence: 99%

Using network dynamic fMRI for detection of epileptogenic foci

et al. 2015

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BackgroundEpilepsy is one of the most prevalent neurological disorders. It remains medically intractable for about one-third of patients with focal epilepsy, for whom precise localization of the epileptogenic zone responsible for seizure initiation may be critical for successful surgery. Existing fMRI literature points to widespread network disturbances in functional connectivity. Per previous scalp and intracranial EEG studies and consistent with excessive local synchronization during interictal discharges, we hypothesized that, relative to same regions in healthy controls, epileptogenic foci would exhibit less chaotic dynamics, identifiable via entropic analyses of resting state fMRI time series.MethodsIn order to first validate this hypothesis on a cohort of patients with known ground truth, here we test individuals with well-defined epileptogenic foci (left mesial temporal lobe epilepsy). We analyzed voxel-wise resting-state fMRI time-series using the autocorrelation function (ACF), an entropic measure of regulation and feedback, and performed follow-up seed-to-voxel functional connectivity analysis. Disruptions in connectivity of the region exhibiting abnormal dynamics were examined in relation to duration of epilepsy and patients’ cognitive performance using a delayed verbal memory recall task.ResultsACF analysis revealed constrained (less chaotic) functional dynamics in left temporal lobe epilepsy patients, primarily localized to ipsilateral temporal pole, proximal to presumed focal points. Autocorrelation decay rates differentiated, with 100 % accuracy, between patients and healthy controls on a subject-by-subject basis within a leave-one-subject out classification framework. Regions identified via ACF analysis formed a less efficient network in patients, as compared to controls. Constrained dynamics were linked with locally increased and long-range decreased connectivity that, in turn, correlated significantly with impaired memory (local left temporal connectivity) and epilepsy duration (left temporal – posterior cingulate cortex connectivity).ConclusionsOur current results suggest that data driven functional MRI methods that target network dynamics hold promise in providing clinically valuable tools for identification of epileptic regions.

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“…Forty‐three PD patients were selected from the Shanghai JiaoTong University School of Medicine in China from August 2013 to August 2015. All subjects were in accordance with the diagnostic criteria for idiopathic Parkinson's disease of United Kingdom Parkinson's Disease Society Brain Bank 15 . None of the patients met the following conditions: (a) invalid dopaminergic therapy; (b) severe psychiatric symptoms, such as schizophrenia symptoms, apathy, suicidal tendencies, and severe depression; (c) history of stroke, brain injury, and intracranial infection; (d) severe heart, liver, lung, kidney, and blood system, endocrine system diseases; (e) history of drug abuse.…”

Section: Methodsmentioning

confidence: 99%

Efforts of subthalamic nucleus deep brain stimulation on cognitive spectrum: From explicit to implicit changes in the patients with Parkinson's disease for 1 year

You

et al. 2020

CNS Neurosci Ther

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Objective To evaluate the cognitive function of Chinese patients with Parkinson's disease PD postsubthalamic nucleus deep brain stimulation (STN‐DBS). Methods Cognitive function was assessed by neuropsychological methods in PD patients. Twenty matched healthy persons served as normal controls. t test, analysis of variance, and chi‐square analysis were used to compare the difference among the groups. Reliable change index was utilized to analyze the changes in cognition from the individual level. Results (a) Improvement in motor function was significantly better after STN‐DBS (P < .01). (b) Notably, the increase error rates of implicit SRTT (serial reaction time task) was significantly higher after STN‐DBS as compared with the conservative therapy group (P = .03). (c) The decline of verbal fluency (explicit) was also significantly higher after STN‐DBS than that in the medication therapy group (P = .03). (d) In the explicit clock‐drawing test, scores had significantly improved after STN‐DBS (P = .04). Conclusions STN‐DBS as a neuromodulatory tool in the Chinese PD population not only improves motor symptoms but also cognitive function to a certain extent, such as the decline of executive function and verbal fluency. The explicit cognitive decline was significantly quicker than that in patients on medication therapy. The improvement of visiospatial function was also noted. Implicit memory impairment during the 1‐year follow‐up period was not observed.

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Clinical utility of the Wechsler Memory Scale—Fourth Edition (WMS-IV) in predicting laterality of temporal lobe epilepsy among surgical candidates

Cited by 18 publications

References 26 publications

Prediction of the clinical and naming status after anterior temporal lobe resection in patients with epilepsy

Prediction of the clinical and naming status after anterior temporal lobe resection in patients with epilepsy

Using network dynamic fMRI for detection of epileptogenic foci

Efforts of subthalamic nucleus deep brain stimulation on cognitive spectrum: From explicit to implicit changes in the patients with Parkinson's disease for 1 year

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