2015
DOI: 10.2147/ijwh.s50016
|View full text |Cite
|
Sign up to set email alerts
|

Clinical utility of ulipristal acetate for the treatment of uterine fibroids: current evidence

Abstract: Uterine myoma is the most common benign uterine tumor in women of reproductive age and occurs in 20%–25% of the worldwide population. No currently approved medical treatment is able to completely eliminate fibroids. Surgery, particularly hysterectomy, predominates as the treatment strategy of choice, even though it is associated with risks and complications and causes infertility. Until recently, gonadotropin-releasing hormone agonists were the only available drugs for the preoperative treatment of fibroids. H… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

1
3
0

Year Published

2016
2016
2023
2023

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 10 publications
(7 citation statements)
references
References 27 publications
1
3
0
Order By: Relevance
“…The advantage of HIFU is that it has the same effect as myomectomy and can cause necrosis of fibroid tissues, but it can avoid the damage of ultrasonic waves to normal tissues, so as to achieve the effect of minimally invasive treatment. This has been confirmed by clinical manifestations of patients and imaging (11,12). At the same time, HIFU has played a safe and effective role in patients with a willingness to have pregnancy, not only to allow uterine cavity a good recovery, but also to retain pregnancy ability (13).…”
Section: Introductionsupporting
confidence: 55%
“…The advantage of HIFU is that it has the same effect as myomectomy and can cause necrosis of fibroid tissues, but it can avoid the damage of ultrasonic waves to normal tissues, so as to achieve the effect of minimally invasive treatment. This has been confirmed by clinical manifestations of patients and imaging (11,12). At the same time, HIFU has played a safe and effective role in patients with a willingness to have pregnancy, not only to allow uterine cavity a good recovery, but also to retain pregnancy ability (13).…”
Section: Introductionsupporting
confidence: 55%
“…Several clinical trials have evaluated the efficacy of UPA in treatment of UFs in terms of ability to reduce menstrual blood loss and reaching amenorrhea. They also evaluated its ability to reduce uterus and fibroid size as well as its impact on quality of life [ 114 , 115 , 121 128 ].…”
Section: Treatment Options For Uterine Fibroidsmentioning
confidence: 99%
“…[2,3] The choice of the appropriate therapy for uterine fibroids is influenced by several factors, including the severity of symptoms, infertility, the tumor characteristics (number, size, and location), the patient's age, wish to preserve the uterus, and the desire of future pregnancies. [4] …”
Section: Introductionmentioning
confidence: 99%
“…[7] Recently, ulipristal acetate (UPA), a selective progesterone receptor modulator, has been introduced as a new medical strategy in the treatment of uterine fibroids with promising results. [4] …”
Section: Introductionmentioning
confidence: 99%