Clinical validation of pinopode as a marker of endometrial receptivity: a randomized controlled trial

Zhang, Qiong; Hao, Jie; Wang, Yonggang; Xu, Bin; Zhao, Jing; Li, Yanping

doi:10.1016/j.fertnstert.2017.07.006

Cited by 41 publications

(38 citation statements)

References 18 publications

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“…Moreover, no major differences in the coverage and morphology of pinopodes was observed in endometrial samples from fertile women compared to those of women with recurrent pregnancy loss, suggesting no direct correlation between pinopode density/morphology and pregnancy success [151]. However, recent studies re-evaluated pinopode utility to identify endometrial receptivity, by demonstrating a strong correlation between pinopode quality and pregnancy rate [152][153][154]. These contrasting results may be explained, at least in part, by sampling variability, and lack of standardization for morphological identification and staging of the pinopodes.…”

Section: Role Of Pinopodesmentioning

confidence: 99%

Molecular Signaling Regulating Endometrium–Blastocyst Crosstalk

Massimiani

Lacconi

Civita

et al. 2019

IJMS

135

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Implantation of the embryo into the uterine endometrium is one of the most finely-regulated processes that leads to the establishment of a successful pregnancy. A plethora of factors are released in a time-specific fashion to synchronize the differentiation program of both the embryo and the endometrium. Indeed, blastocyst implantation in the uterus occurs in a limited time frame called the “window of implantation” (WOI), during which the maternal endometrium undergoes dramatic changes, collectively called “decidualization”. Decidualization is guided not just by maternal factors (e.g., estrogen, progesterone, thyroid hormone), but also by molecules secreted by the embryo, such as chorionic gonadotropin (CG) and interleukin-1β (IL-1 β), just to cite few. Once reached the uterine cavity, the embryo orients correctly toward the uterine epithelium, interacts with specialized structures, called pinopodes, and begins the process of adhesion and invasion. All these events are guided by factors secreted by both the endometrium and the embryo, such as leukemia inhibitory factor (LIF), integrins and their ligands, adhesion molecules, Notch family members, and metalloproteinases and their inhibitors. The aim of this review is to give an overview of the factors and mechanisms regulating implantation, with a focus on those involved in the complex crosstalk between the blastocyst and the endometrium.

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Section: Role Of Pinopodesmentioning

confidence: 99%

Molecular Signaling Regulating Endometrium–Blastocyst Crosstalk

Massimiani

Lacconi

Civita

et al. 2019

IJMS

135

View full text Add to dashboard Cite

show abstract

“…Implantation is a complex, precisely timed event, and it is an important limiting step in reproduction for many women. Implantation failures may be related to immunologic factors, endocrine or hormonal disruptions, lack of endometrial receptivity, anatomic defects (leiomyomas, intrauterine adhesions) or embryo factors ( Bechi et al 2010 , Makker & Goel 2013 , Qiong et al 2017 , Zhang et al 2017 ). However, there are many cases in which a cause for implantation failure cannot be found.…”

Section: Introductionmentioning

confidence: 99%

ESTROGEN-REGULATED miRNA-27b IS ALTERED BY BISPHENOL A IN ENDOMETRIAL STROMAL CELLS

Reed

Babayev²,

Chen

et al. 2018

Reproduction

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MicroRNAs (miRs) are small molecules important for regulation of transcription and translation. The objective was to identify hormonally regulated miRs in human endometrial stromal cells and to determine the impact of the endocrine disruptor, bisphenol A (BPA), on those miRs. miR microarray analysis and multiple confirmatory cell preparations treated with 17β-estradiol (E2) and BPA altered miR-27b, let-7c, let-7e and miR-181b. Further, decidualization downregulated miR-27b. VEGFB and VEGFC were validated as targets of miR-27b. Identification of miR-27b target genes suggests that BPA and E2 downregulate miR-27b thereby leading to upregulation of genes important for vascularization and angiogenesis of the endometrium during the menstrual cycle and decidualization.

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“…7 Since then, integrin, 8 glycodelin, 9 mucin 1, 10 leukemia inhibitory factor (LIF), 8,11 and HOXA-10 transcription factor 12 have also been described as potential endometrial biomarkers. Pinopodes were reported as a biomarker to assess endometrial receptivity since their putative expression coincides with the window of implantation.…”

Section: Introductionmentioning

confidence: 99%

“…Pinopodes were reported as a biomarker to assess endometrial receptivity since their putative expression coincides with the window of implantation. 7 Since then, integrin, 8 glycodelin, 9 mucin 1, 10 leukemia inhibitory factor (LIF), 8,11 and HOXA-10 transcription factor 12 have also been described as potential endometrial biomarkers. Nevertheless, only a few markers are currently utilized in clinical practice due to the conflicting results and technical difficulties for their use on patients.…”

Section: Introductionmentioning

confidence: 99%

Intrauterine infusion of human chorionic gonadotropin before embryo transfer in IVF/ET cycle: The critical review

Zhang

Chen

Wang

et al. 2019

American J Rep Immunol

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Intrauterine infusion of human chorionic gonadotropin (IUI‐hCG) has been proposed to improve the outcome of in vitro fertilization‐embryo transfer (IVF‐ET), since it plays a critical role in synchronizing endometrial and fetal development. As the early mediator from embryo, hCG promotes the decidualization, angiogenesis, maternal immune tolerance, and trophoblast invasion, favoring successful implantation of embryo. Although multiple clinical trials have been conducted to verify the efficacy of IUI‐hCG on IVF‐ET outcome in recent years, the findings remained controversial. The difference in study design and population might be the cause to the different consequences after administration of hCG. More importantly, the endometrial receptivity, which might affect the efficacy of IUI‐hCG, has not been assessed in women receiving this intervention. Selecting the right population suitable for IUI‐hCG based on known etiology would be crucial in enhancing its efficacy and minimize any possible complications. Investigation of optimal indications for IUI‐hCG should be highlighted in the future.

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Clinical validation of pinopode as a marker of endometrial receptivity: a randomized controlled trial

Abstract: ChiCTR-OOC-14005617; ChiCTR-OOC-15005882.

Cited by 41 publications

References 18 publications

Molecular Signaling Regulating Endometrium–Blastocyst Crosstalk

Molecular Signaling Regulating Endometrium–Blastocyst Crosstalk

ESTROGEN-REGULATED miRNA-27b IS ALTERED BY BISPHENOL A IN ENDOMETRIAL STROMAL CELLS

Intrauterine infusion of human chorionic gonadotropin before embryo transfer in IVF/ET cycle: The critical review

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