Clinical validation of SPECT attenuation correction using x-ray computed tomography–derived attenuation maps: Multicenter clinical trial with angiographic correlation

Abstract

CT-based AC of SPECT images consistently improved overall diagnostic performance of readers with different interpretive attitudes and experience. CT-based AC is well suited for routine use in clinical practice.

Impact of respiratory motion correction on SPECT myocardial perfusion imaging using a mechanically moving phantom assembly with variable cardiac defects

“…6 A combination of motion correction with attenuation correction enhanced the reduction of artifacts. Attenuation correction improved the uptake values in the basal segments 19 , while motion correction improved the uptake values in the anterior and inferior regions and to a lesser extent in the lateral and septal regions. Applying motion correction on AC-SPECT images, the uptake values were increased in the anterior and inferior regions, in which the small defects were located, with the result 50% of the defects to be reported and evaluated as FN, as in the case of static phantoms (Table 3).…”

Real-time breath-hold triggering of myocardial perfusion imaging with a novel cadmium-zinc-telluride detector gamma camera

“…The use of any other non-SPECT MPI such as MRI or PET would have inferred many technical differences and would have required complex protocols with co-injection of the respective flow tracer. Therefore, we have used CT AC SPECT as standard of reference, as CT-based AC for SPECT has been showed to improve accuracy [18]. Finally, breathhold may potentially pose a problem in patients with dyspnoea.…”

Diagnostic accuracy of myocardial perfusion imaging with single photon emission computed tomography and positron emission tomography: a comparison with coronary angiography

“…Recently, Bateman and colleagues [8] described a higher diagnostic accuracy of 82 Rubidium PET compared to 99m Tc sestamibi SPECT, but again attenuation correction was only used for PET, although it has been shown to substantially improve accuracy in SPECT [18][19][20].…”