Clinical Value, Approaches to Diagnostics and Therapy of Active Cytomegalovirus Infection in Pregnant Women and Newborns

Шахгильдян, В. И.

doi:10.21518/2079-701x-2016-12-62-72

Cited by 2 publications

(2 citation statements)

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“…В связи с тем, что в большинстве случаев как перинатальной, так и постнатальной ЦМВ/ЭБВ инфекции страдают печень и мозг, важно при клинически первично манифестной или латентной ЦМВ/ЭБВ инфекции следующей манифестацией применять в комплексной терапии средств восстанавливающие энергетический баланс организма. Главным образом средства, восстанавливающие функцию печени и способствующие элиминации этих вирусов из ретикуло-эндотелиальной системы и клеток крови (где вирусы могут сохраняться длительно в латентной форме), как дополнение к противовирусной терапии [4].…”

Section: Results Of Pathogenetic Therapy With the Drug N-pentoxynial In Children With Current Latent Cmv/ebv Infectionunclassified

“…Предпосылками для проведения данного Экспертного совета послужила серия значимых событий для лечения СД 2 типа в Республике Казахстан, а именно -обновление Казахстанского Консенсуса по диагностике и лечению сахарного диабета [1] в 2016 году и внесение изменений в клинический протокол лечения СД 2 типа [2] в августе 2017 года (включение класса SGLT-2 ингибиторов на каждом этапе лечения СД) в соответствии с последними международными рекомендациями по лечению СД [3,4].…”

Section: эндокринологияunclassified

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Results of pathogenetic therapy with the drug N-Pentoxynial in children with current latent CMV/EBV infection

Idrissova¹,

Mustafaeva²,

Zhaksybek

et al. 2020

Medicine

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In the perinatal and early postnatal period, congenital (antenatal) and intrauterine (intra- and perinatal) CMV are more often manifested by lesions of the liver, brain and organ of vision. Objective. To study the effect of pathogenetic therapy with the metabolic and hepatoprotective drug N-Pentoxinial on the course of persistent CMV/EBV infection of perinatal genesis in children. Material and Methods. The course of latent perinatal cytomegalovirus (CMV) and Epstein-Bar viral infections in children was studied against the background of antiviral treatment (specific against CMV/ EBV immunoglobulin - Neocytect and recombinant alpha-interferon - Viferon No. 10), followed (immediately after 5-7 days after antiviral) by the appointment of 1-2 courses of N-Pentoxinal for 10-20 days. The main group consisted of 20 children (average age 5.4±1.4 years), the control group consisted of 10 children (average age 5.1±1.7 years). All underwent general clinical and virological studies to confirm the diagnosis. Result and discussions. The results obtained indicate that the addition of N-pentoxynial to the basic antiviral therapy for CMV and EBV infection in children improves (accelerates) the elimination of the virus from biological fluids (blood and urine), as well as more rapid normalization of transaminases and alkaline phosphatase. There were no reliably proven allergic reactions. Conclusions. The drug N-Pentoxinial can be prescribed after antiviral therapy for perinatal CMV, EBV infection in order to consolidate the results of antiviral treatment and normalize liver function, especially bile secretion. Keywords: latent perinatal cytomegalovirus/Epstein-Barr viral infection, children, therapy.

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Section: Results Of Pathogenetic Therapy With the Drug N-pentoxynial In Children With Current Latent Cmv/ebv Infectionunclassified

Section: эндокринологияunclassified

Results of pathogenetic therapy with the drug N-Pentoxynial in children with current latent CMV/EBV infection

Idrissova¹,

Mustafaeva²,

Zhaksybek

et al. 2020

Medicine

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Cytomegalovirus Infection in Pregnant Women With Hiv Infection

Жукова

Шахвердян

2018

VIČ-infekc. immunosupr.

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Purpose: еstablishment of the frequency of infection and clinical forms of cytomegalovirus infection in pregnant women with HIV infection. Materials and methods. A retrospective analysis of medical records of 254 HIV-infected pregnant women of the Krasnodar Territory was conducted, which were observed in the framework of the current regulations on HIV infection and the management of pregnant women. Verification of cytomegalovirus infection and distribution of clinical forms was carried out by serological tests. The comparison group is a prospective analysis of 29 pregnant women with HIV infection who were additionally examined for cytomegalovirus infection by polymerase chain reaction. Results. Latent form of CMV infection was diagnosed in 220 (90,5%) of HIV-infected pregnant women, primary — in 5 (2,1%) and reactivated (late primary, reinfection)— in 18 (7,4%). Cytomegalovirus infection frequency increase with growing pregnant, increasing stages of HIV infection, more frequent multiplicity pregnancy, reducing CD4+ T-lymphocytes and increase in HIV RNA. The well-being of obstetric history had no effect on the incidence of infection with cytomegalovirus and various forms of CMV infection. Reactivated forms of cytomegalovirus infection were significantly more frequent in pregnant women with HIV infection at the lowest CD4 + T-lymphocyte counts, maximal HIV viremia, later onset of perinatal antiretroviral prophylaxis, but did not depend on the well-being of the obstetric anamnesis. A comparison group study demonstrated the presence of latent cytomegalovirus infection in all pregnant women, confirmed by the detection of only specific IgG. From the whole blood, the DNA of CMV in low concentration was isolated by PCR method in 1 (3,4%) of the patient, from the cervix — in 8 (27,6%). The amount of detected CMV DNA in the cervix was different, had a direct correlation with the level of HIV RNA of pregnant women and did not depend on the number of CD4-lymphocytes. The calculation of the relative risk in our observations demonstrated that the presence of cytomegalovirus in the cervix did not increase the risk of premature termination of pregnancy.

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Clinical Value, Approaches to Diagnostics and Therapy of Active Cytomegalovirus Infection in Pregnant Women and Newborns

Cited by 2 publications

References 11 publications

Results of pathogenetic therapy with the drug N-Pentoxynial in children with current latent CMV/EBV infection

Results of pathogenetic therapy with the drug N-Pentoxynial in children with current latent CMV/EBV infection

Cytomegalovirus Infection in Pregnant Women With Hiv Infection

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