BackgroundPositron emission tomography (PET)/MRI combines the characteristics of metabolism imaging and high soft tissue resolution, and could provide high diagnostic efficacy for assessment of pleural invasion (PI) of lung cancer.PurposeTo investigate the application of 18F‐fluorodeoxyglucose (FDG) PET/MRI for predicting PI of lung cancer with the maximum diameter ≤3 cm.Study TypeProspective.PopulationA total of 44 patients with non‐small cell lung cancer (NSCLC), age from 39 to 79 years old, including 19 (56.82%) females.Field Strength/SequenceA 3‐T, hybrid PET/MRI including axial fast spin echo respiratory‐triggered T2 fat‐suppressed imaging (T2FS) and echo planar imaging diffusion‐weighted imaging (DWI).AssessmentThe maximum standardized uptake value (SUVmax) of all lesions was measured on PET images. Localized effusion outside the contact between the nodules and the pleura on T2FS and signal at the contact between the nodules and the pleura on DWI were evaluated by experienced physicians through visual assessment of the MRI sequences.Statistical TestsThree models (models 1–3) were developed, incorporating CT, CT and PET, PET and MRI features, and Lasso regression was used in feature selection. The receiver operating characteristic (ROC) curve for PI diagnosis was visualized for each model, and the area under the curve (AUC) was calculated. The DeLong test was used to compare the different AUCs. A P value < 0.05 was considered statistically significant.ResultsThe AUC of models 1–3 was 0.762, 0.829, and 0.915, respectively. The DeLong test showed a statistically significant difference between the AUCs of model 1 vs. model 3, while the differences between the AUCs of model 1 vs. model 2 (P = 0.253) and model 2 vs. model 3 (P = 0.075) were not statistically significant.Data conclusion18F‐FDG PET/MRI might show high predictive value for lung adenocarcinoma smaller than 3 cm with PI.Evidence Level1Technical EfficacyStage 2