Clinical value of bronchial provocation testing in childhood asthma

Cavanaugh, Michael; Bronsky, Edwin A.; Buckley, Jerome M.

doi:10.1016/0091-6749(77)90175-0

Cited by 42 publications

(18 citation statements)

References 15 publications

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“…For routine diagnostic procedures, it would be enough to resort to the skin test method, particularly in view of its easy performance with low cost and relatively less risk and complexity. A similar relation between skin test reaction and BPT has been pointed out by some previous workers, but their results were not as significant as the present findings (Aas 1970(Aas , 1975Cavanaugh et al 1977). Aüergenicity of the various pollen types studied here has been evaluated in terms of the intensity of their skin test positivity followed by BPT studies.…”

Section: Discussionsupporting

confidence: 73%

Studies on the allergenicity of nine tropical pollen allergens

Prakashkumar

Mathew

Ravindran

1998

Grana

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Section: Discussionsupporting

confidence: 73%

Studies on the allergenicity of nine tropical pollen allergens

Prakashkumar

Mathew

Ravindran

1998

Grana

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“…In former studies, the predictive value of the SPT had been predominantly investigated . In children, a wheal size of ≥4.5 mm showed a sensitivity of 75% and a specificity of 86% to predict an EAR (AUC 0.85) .…”

Section: Discussionmentioning

confidence: 99%

Bronchial allergen challenges in children – safety and predictors

Schulze

Reinmüller

Herrmann

et al. 2013

Pediatric Allergy Immunology

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“…For cat allergy it has a high degree of sensitivity and a positive response to SPT has been shown to predict a positive response to a bronchial challenge in 92% of the subjects [10].…”

Section: Discussionmentioning

confidence: 99%

Cat sensitivity: 7-yr audit in children attending a paediatric allergy clinic in North Italy

Pescollderungg¹,

Pietrobelli²,

Boner³

2000

Eur Respir J

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Sensitivity to cats and exposure to cat allergen is a common cause of asthma exacerbation in children. To date, there is no data on the prevalence of cat sensitivity in children living in North Italy. Therefore, a 7-yr survey was performed in patients attending an allergy clinic for the first time.Skin prick tests (SPT) for perennial allergens and for pollens relevant to the region were performed in 4,957 children attending the outpatient clinic 1992±1998. A questionnaire on present or past cat ownership was presented to all cat-skin prick test positive children. An evaluation of cat ownership on the general population was made by telephone interview on a random sample of 1,268 families living in the same area.With a 3-mm wheal as a positive cut-off 439 (8.85%) children had a positive SPT to cats. Of these 103 (23.4%) had a cat at home and 336 (76.6%) never had a cat in the house. With a greater positive cut-off (a wheal diameter $4 mm) 140 (2.8%) showed a positive SPT to cats of these 35 (25%) had a cat at home and 105 (75%) had only an indirect exposure to the pet. Of the telephone interviewed families; 16% stated they had a cat at home.Cat sensitivity is less prevalent in Italy, in this hospital based population, compared with other European countries and this is in agreement with a lower rate of cat ownership. Cat sensitivity was three times more frequent in children who never had a cat at home, than in children living with cats, when the selected positive cut-off was either a wheal diameter of 3 mm or $4 mm. Thus in a population with a low prevalence of cat ownership public exposure seems to be more important than domestic exposure for the development of sensitivity. Eur Respir J 2000; 16: 857±860. Allergy to indoor allergens (house dust mites, domestic pets and cockroaches) is a major cause of ill health in children. In the USA, cat and dog allergens sensitivity has been shown to occur in up to 67% of asthmatic children in settings where they are the dominant indoor allergens [1,2]. In the UK, pet ownership is very common and approximately one-third of homes have a cat and one-quarter a dog [3]. Pets are the second most important cause of allergy in the domestic environment in the UK, and up to 40% of asthmatic children are sensitized to cat and/or dog allergens [4]. In a population survey in Northern Sweden cat and dog allergens elicited the greatest number of positive skin test responses; the proportion of children sensitized against cats was 13.4% and dogs 8.7% [5]. Furthermore, sensitization to cat allergen is common among asthmatic children in Japan where cat-specific immunoglobulin E (IgE) were found in sera of 70% of asthmatic children who kept cats and 34% of patients who had never kept cats at home [6]. In the German Multicenter Atopy Study cumulative rates of sensitization to cat antigen dI (Fel dI) among children with a family history of atopy were 5±6% in the first 3 yrs of life [7].Since no data on the prevalence of cat sensitivity in children is available from North Italy, the preva...

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Clinical value of bronchial provocation testing in childhood asthma

Cited by 42 publications

References 15 publications

Studies on the allergenicity of nine tropical pollen allergens

Studies on the allergenicity of nine tropical pollen allergens

Bronchial allergen challenges in children – safety and predictors

Cat sensitivity: 7-yr audit in children attending a paediatric allergy clinic in North Italy

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