Clinical Value of C-Reactive Protein/Platelet Ratio in Neonatal Sepsis: A Cross-Sectional Study

Li, Xiaojuan; Li, Tiewei; Wang, Jingjing; Feng, Yichuan; Ren, Chong; Xu, Zhe; Yang, Junmei; Zhang, Qian; An, Caiyan

doi:10.2147/jir.s334642

Cited by 12 publications

(15 citation statements)

References 38 publications

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“…Infection markers such as PCT and CRP are commonly used for the adjuvant diagnosis of sepsis, 4 , 5 and their role in the diagnosis and prediction of sepsis is still being explored. 45 , 46 In this study, a diagnostic model by a combination of the four validated indexes and two infection markers was established, with the highest AUC‐ROC of 0.772 than that of PCT or CRP, although there were no significant differences between each combination AUC and AUC of PCT or CRP. B2M, VCAM1, and ApoE, besides ApoC3, already can be detected in clinical laboratory, which provided the clinical application possibility for septic diagnosis.…”

Section: Discussionmentioning

confidence: 96%

Identification of novel biomarkers for sepsis diagnosis via serum proteomic analysis using iTRAQ‐2D‐LC‐MS/MS

Ren

Yan

et al. 2021

Clinical Laboratory Analysis

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Section: Discussionmentioning

confidence: 96%

Identification of novel biomarkers for sepsis diagnosis via serum proteomic analysis using iTRAQ‐2D‐LC‐MS/MS

Ren

Yan

et al. 2021

Clinical Laboratory Analysis

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“…The combination of platelets and inflammatory biomarkers has been demonstrated to be associated with poor prognoses in a variety of clinical situations, including sepsis and cardiovascular diseases [34][35][36]. Li X found that a higher CPR was an independent risk factor for neonatal sepsis [11]. In addition, a previous study demonstrated that NLPR was associated with early acute kidney injury in cardiovascular surgery [31].…”

Section: Discussionmentioning

confidence: 98%

“…To date, numerous inflammation-related indices such as C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) and fibrinogen (FIB), have been extensively used as prognostic values for many diseases [8][9][10]. Platelets play an important role in haemostasis and coagulation and are regulators of inflammation by controlling inflammation, and tissue integrity, as well as by defending against infection [11]. Some studies have indicated that patients with severe sepsis/septic shock have lower platelet count [12].…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of platelet count-related ratios on admission in patients with pyogenic liver abscess

Yu¹,

Qin²,

Peng³

et al. 2022

BMC Infect Dis

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Objective The purpose of the current study was to evaluate the association between C-reactive protein-to-platelet ratio (CPR), neutrophil-to-lymphocyte*platelet ratio (NLPR) and fibrinogen-to-platelet ratio (FPR) and the prognoses of pyogenic liver abscess (PLA) patients. Methods A cohort of 372 patients with confirmed PLA were enrolled in this retrospective study between 2015 and 2021. Laboratory data were collected on admission within 24 h. The demographic characteristics and clinical features were recorded. Risk factors for outcomes of PLA patients were determined via multivariate logistic regression analyses, and optimal cut-off values were estimated by using the receiver operating characteristic (ROC) curve analysis. Results Out of 372 patients, 57.8% were men, 80 (21.5%) developed sepsis, and 33 (8.9%) developed septic shock. The levels of CPR, NLPR and FPR were significantly increased in the development of sepsis, and prolonged hospital stays in PLA patients. The multivariate logistic regression analysis indicated that the CPR (OR: 2.262, 95% CI: 1.586–3.226, p < 0.001), NLPR (OR: 1.118, 95% CI: 1.070–1.167, p < 0.001) and FPR (OR: 1.197, 95% CI: 1.079–1.329, p = 0.001) were independent risks of PLA patients with sepsis, and NLPR (OR: 1.019, 95% CI: 1.004–1.046, p = 0.019) was shown to be an independent predictor of prolonged hospital stays. The ROC curve results showed that the three biomarkers had different predictive values, and CPR proved to work best, with a ROC value of 0.851 (95% CI: 0.807–0.896, p < 0.001) for sepsis. Conclusion Higher levels of CPR, NLPR and FPR were associated with a higher risk of poor outcomes. Moreover, a high CPR level performed best when predicting the clinical outcome in PLA patients.

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“…CRP is an acute inflammatory protein produced by the liver and significantly increases when there is inflammation or infection in your body. Studies have demonstrated that CRP was an important predictor and risk factor for sepsis and pneumonia [22][23][24][25][26]. ALB was the most abundant protein found in blood produced by the liver.…”

Section: Discussionmentioning

confidence: 99%

C-Reactive Protein-to-Albumin Ratio as an Early Biomarker to Identify Sepsis in Neonates with Pneumonia

Kang

Wen

et al. 2022

Mediators of Inflammation

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Objectives. Neonates with pneumonia often also have sepsis, and the identifying sepsis from pneumonia may be a challenge for clinicians. However, there are no available data regarding the clinical value C-reactive protein-to-albumin ratio (CAR) in identifying sepsis in neonates with pneumonia. The aim of this study was to evaluate the clinical value of CAR in identifying sepsis in neonates with pneumonia. Methods. 847 neonates with pneumonia were included in this study, of which 511 neonates were diagnosed with sepsis. Neonates were divided into the sepsis group and the nonsepsis group. All neonates underwent extensive and necessary clinical and laboratory tests. CAR was calculated as serum C-reactive protein (ng/ml)/albumin (mg/ml). All statistical analyses were performed using the statistical package SPSS 24.0, as appropriate. Results. Compared with the nonsepsis group, neonates with sepsis have a higher CAR ( P < 0.001 ). Further analysis showed that the prevalence of neonates with sepsis increased significantly from 41.0% in the low CAR group ( CAR ≤ 0.024 × 10 − 3 ) to 80.0% in the high CAR group ( CAR > 0.024 × 10 − 3 ) ( P < 0.001 ). Correlation analysis showed that there was a strong positive correlation between CAR and PCT ( r = 0.452 , P < 0.001 ), nSOFA ( r = 0.267 , P < 0.001 ), and the prolonged length of hospital stay ( r = 0.311 , P < 0.001 ). Multiple logistic regression showed that CAR was an independent risk factor for the presence of sepsis in neonates with pneumonia. Receiver operating characteristic curve analysis revealed that CAR had adequate discriminatory power in predicting sepsis in neonates with pneumonia (area under curve AUC = 0.76 , 95% CI 0.73-0.79, P < 0.001 ). Conclusions. CAR can be used as a new marker to identify sepsis in neonates with pneumonia.

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Clinical Value of C-Reactive Protein/Platelet Ratio in Neonatal Sepsis: A Cross-Sectional Study

Cited by 12 publications

References 38 publications

Identification of novel biomarkers for sepsis diagnosis via serum proteomic analysis using iTRAQ‐2D‐LC‐MS/MS

Identification of novel biomarkers for sepsis diagnosis via serum proteomic analysis using iTRAQ‐2D‐LC‐MS/MS

Prognostic value of platelet count-related ratios on admission in patients with pyogenic liver abscess

C-Reactive Protein-to-Albumin Ratio as an Early Biomarker to Identify Sepsis in Neonates with Pneumonia

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