Clinical Value of Creatinine Kinase in the Diagnosis of Ectopic Pregnancy

Abstract

The role of creatinine kinase (CK) in the diagnosis of ectopic pregnancy was studied. We selected 56 patients divided into 4 groups. Group A consisted of 10 patients with asymptomatic tubal pregnancy, group B consisted of 11 patients with symptomatic tubal pregnancy whereas groups C and D consisted of 20 and 15 patients with normal and threatened intrauterine pregnancy, respectively. Serum samples of CK were taken from all patients on admission. No significant difference was observed in the median CK value of cases with normal pregnancy (58.5 ± 7.24 U/l, mean ± SE) as well as threatened abortion (73 ± 11.43 U/l) compared to that of cases with asymptomatic 58.5 ± 12.42 U/l) or symptomatic tubal pregnancy (59 ± 10.08 U/l). We conclude that serum CK is not a useful biochemical marker in the diagnosis of ectopic pregnancy.

Diagnostic significance of total creatine kinase and its isoform in tubal ectopic pregnancy

“…The cut‐off of total CK to predict tubal rupture was 147 IU/L, which is close to our previous report . Most of the previous studies which have reported conflicting interest in this frame were carried on small sample groups . Gnisci et al .…”

“…7 Most of the previous studies which have reported conflicting interest in this frame were carried on small sample groups. [8][9][10] Gnisci et al elucidated the significance of total CK in the management of EP and reported that the CK levels were found to predict the success of methotrexate injection in EP cases. 3 Limited data is available on the isoforms of CK in EP.…”

“…However, we did not study its discriminating potential from intrauterine (IU) abortions. While few other studies have pointed out that though it is higher in tEP it is inefficient in discriminating IU abortion and hence has less utility in early diagnosis …”

“…While few other studies have pointed out that though it is higher in tEP it is inefficient in discriminating IU abortion and hence has less utility in early diagnosis. [8][9][10] Creatine kinase has three distinct isoenzyme forms, namely, CK-MM, -MB and -BB. 11 Measuring CK isoforms along with total CK may improve its diagnostic potential in tEP.…”

Evaluation of serum creatine kinase in ectopic pregnancy with reference to tubal status and histopathology

“…We did not find any difference in creatine kinase levels between ruptured isthmic and ampullary ectopic pregnancy in the women with symptoms of peritoneal irritation, which could provide a clue as to the extent of tubal damage and associated intraperitoneal bleeding. Furthermore, no difference could be demonstrated in creatine kinase levels between symptomatic and asymptomatic patients, which agrees with previous reports 2,3,12 .…”