Clinical Value of Early Assessment of Hyperfibrinolysis by Rotational Thromboelastometry During Postpartum Hemorrhage for the Prediction of Severity of Bleeding: A Multicenter Prospective Cohort Study in the Netherlands

Abstract

(Acta Obstet Gynecol Scand. 2022;101:145–152. doi: 10.1111/aogs.14279) Rotational thromboelastometry (ROTEM) provides point-of-care technology for detecting hyperfibrinolysis, a condition that can precede coagulopathy and lead to excessive bleeding with childbirth. Early awareness of the contribution of hyperfibrinolysis to postpartum hemorrhage (PPH) allows for targeted anti-fibrinolytic treatment that can reduce the risk of severe bleeding. This study investigates the efficacy of ROTEM for predicting the development of excessive blood loss by timely detection of hyperfibrinolysis at the earliest stages of PPH.