Clinical value of genetically diagnosed lymph node micrometastasis for patients with oral squamous cell carcinoma

Yamazaki, Yutaka; Chiba, Itsuo; Hirai, Atsuko; Satoh, Chiharu; Sakakibara, Noriyuki; Notani, Ken‐ichi; Iizuka, Tadashi; Totsuka, Yasunori

doi:10.1002/hed.20200

Cited by 27 publications

(18 citation statements)

References 19 publications

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“…Nieuwenhuis et al found that the survival of patients with cN0 but with one or more micrometastases (detected by molecular analysis) was worse compared to patients without micrometastases (10). Similar results were published by Xu et al (18)(19) and Yamazaki et al (21). Presence of unrecognized micrometastases or ones left in situ can also explain regional tumor recurrence in patients with N0 stage or in patients with N+ stage after selective neck dissection.…”

Section: Discussionmentioning

confidence: 60%

Detection of Cervical Lymph Node Micrometastases in Patients with Squamous Cell Carcinoma of the Oral Cavity, Pharynx and Larynx

Čelakovský

Kalfeřt

Smatanová

et al. 2015

Acta Med. (Hradec Kralove, Czech Repub.)

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Summary:Background: The goal of this prospective study was to determine the frequency of micrometastases in patients with squamous cell carcinoma (SCC) of the oral cavity, pharynx and larynx in whom elective neck dissection was indicated (cN0). Patients and Methods: A total of 12 patients (10 males and 2 females) were enrolled in the study. The age ranged 42-73 years (median 62 years). Elective neck dissection was performed in all patients (8 ipsilateral, 4 bilateral) and a total of 256 lymph nodes were removed and sent for microscopic examination. Results: The presence of tumor cells in cervical lymph nodes was found in 5/12 (42%) patients. Micrometastases of SCC were found in two patients and isolated tumor cells (ITC) in two other patients. In the remaining one patient with oropharyngeal SCC, a micrometastasis of papillary thyroid carcinoma (PTC) was detected. Positive lymph nodes were localized in level II in three patients with SCC of larynx, hypopharynx and tongue base, respectively, in level I in one patient with SCC of oral tongue and in level III in one patient with PTC. Conclusion: Our results indicate that SCC of head and neck has a high potential for creating micrometastases which frequency is higher compared to clinically detected macrometastases. Therefore, elective neck dissection or radiotherapy of the neck should be considered in patients with high risk of occult metastases or micrometastases.

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Section: Discussionmentioning

confidence: 60%

Detection of Cervical Lymph Node Micrometastases in Patients with Squamous Cell Carcinoma of the Oral Cavity, Pharynx and Larynx

Čelakovský

Kalfeřt

Smatanová

et al. 2015

Acta Med. (Hradec Kralove, Czech Repub.)

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“…[23][24][25][26] However, the previous studies did not address specifically the prognostic significance of p53 overexpression in the lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

P53 expression in squamous cell carcinomas of the supraglottic larynx and its lymph node metastases

Cabanillas

Rodrigo

Astudillo

et al. 2007

Cancer

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BACKGROUND.Although p53 overexpression is frequent in head and neck squamous cell carcinomas (HNSCCs), controversy remains regarding the prognostic significance of that overexpression. The objective of this study was to investigate the expression pattern and prognostic significance of p53 expression in HNSCC of the same location, treated in the same way, and with long‐term follow‐up.METHODS.P53 expression was determined by immunohistochemistry in paraffin‐embedded tissue specimens from 107 consecutive patients (107 primary squamous cell carcinomas of the supraglottic larynx and 46 matched lymph node metastases). All patients underwent surgical resection and bilateral neck dissection.RESULTS.A strong correlation was observed between p53 expression in the primary tumor and in the matched lymph node metastases (P = .0001). P53 overexpression in the lymph nodes was an independent predictor of regional recurrence (P = .027). Likewise, expression of p53 in the lymph nodes correlated significantly with disease‐specific survival (P = .018). Five years after treatment, 70% of patients with p53‐negative, metastatic lymph nodes remained alive, whereas only 30% of patients with p53‐positive lymph nodes remained alive. In multivariate analysis, lymph node status and p53 expression in the lymph nodes remained associated with survival.CONCLUSIONS.The current data suggested that, although p53 overexpression is common in supraglottic carcinomas, its expression in the primary tumor is of limited clinical significance. However, the results supported the role of p53 in the lymph node metastases as an independent predictor of regional failure and a poor prognosis in patients with HNSCC. A prospective trial is indicated to validate these findings. Cancer 2007. © 2007 American Cancer Society.

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“…It is suggested that micrometastasis to regional lymph nodes leads to poor prognosis. 3 The presence of lymph node metastasis is one of the independent prognostic factors for predicting the outcome of patients with oral SCC. Tumor invasion and lymph node status are strongly correlated with a patient's survival.…”

Section: Introductionmentioning

confidence: 99%

Gene expression profile changes correlated with lymph node metastasis in oral squamous cell carcinoma

et al. 2008

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The purpose of this research was to identify biomarkers for predicting cervical lymph node metastasis in oral squamous cell carcinoma (OSCC). We surveyed the expressions of 1289 cancer-related genes in 41 cases of OSCC by cDNA array analysis. We extracted genes upregulated or downregulated in their expression in association with lymph node metastasis. Of 1289 cancer-related genes, we identified 39 genes differentially expressed in OSCC with or without lymph node metastasis. Expression levels of 9 genes were lower, and those of 30 genes were higher, in node-positive cases. The genes expressed at higher levels in node-positive cases included angiogenesis-related molecules, cell adhesion molecules, and proteolytic enzymes. We suggest that these characteristic genes could provide, if verifiable, useful information for predicting the risk of lymph node metastasis in OSCC.

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Clinical value of genetically diagnosed lymph node micrometastasis for patients with oral squamous cell carcinoma

Abstract: These results indicate that a high rate of micrometastasis in cervical lymph nodes of oral SCCs and patients with multiple or lower neck spread of micrometastases have a poor prognosis; they should be treated with postoperative adjuvant therapy.

Cited by 27 publications

References 19 publications

Detection of Cervical Lymph Node Micrometastases in Patients with Squamous Cell Carcinoma of the Oral Cavity, Pharynx and Larynx

Detection of Cervical Lymph Node Micrometastases in Patients with Squamous Cell Carcinoma of the Oral Cavity, Pharynx and Larynx

P53 expression in squamous cell carcinomas of the supraglottic larynx and its lymph node metastases

Gene expression profile changes correlated with lymph node metastasis in oral squamous cell carcinoma

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