Clinical value of magnetic resonance imaging in preoperative T staging of gastric cancer and postoperative pathological diagnosis

Huo, Xianying; Yuan, Kuangsheng; Shen, Y T; Li, Min; Wang, Qi; Xing, Lingxiao; Shi, Guo‐Ming

doi:10.3892/ol.2014.2135

Cited by 11 publications

(12 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the protocol of acquiring images has improved with the use of a respiratory trigger (6). In the present study, all gastric and duodenal cancers staged >T2 were detectable by DWI and DWIBS/T2 (19). DWI and DWIBS/T2 exhibited a strong signal and contrast against the surrounding tissues.…”

Section: Discussionmentioning

confidence: 79%

Diffusion-weighted whole-body imaging with background body signal suppression/T2-weighted image fusion of gastrointestinal cancers

Tomizawa

Shinozaki

Fugo

et al. 2016

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Abstract. Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) yields positive results for cancer against the surrounding tissues. The combination of DWIBS and T2-weighted images (DWIBS/T2) in the diagnosis of gastrointestinal tract cancers was retrospectively analyzed in the present study. Patients were subjected to magnetic resonance imaging after cancer was diagnosed through specimens obtained via biopsy or endoscopic mucosal resection. Sixteen patients were assessed between July, 2012 and June, 2013 and the correlation between detection with DWIBS/T2 and T staging was analyzed. Regarding patients who underwent surgery, the correlation between detection with DWIBS/T2 and the diameter or depth of invasion was analyzed. All cancers that had advanced to >T2 stage were detectable by DWIBS/T2, whereas all cancers staged as T2) or invading beyond the muscularis propria. IntroductionEndoscopy is the gold standard for diagnosing cancers of the gastrointestinal tract, including the esophagus, stomach, colon and rectum (1,2). However, endoscopy is not suitable for evaluating the depth of invasion and extent of cancer, as it only allows observation of the lumen. Endoscopic ultrasonography (EUS) and contrast-enhanced computed tomography (CE-CT) are performed to assess the structure of the primary lesion, the depth of invasion into the surrounding tissues and distant metastasis (3,4). Assessing the depth of invasion may occasionally be difficult due to the weak contrast of the cancer against the surrounding tissues. Therefore, an imaging modality with a strong signal and contrast would facilitate the assessment of the depth of tumor invasion.Magnetic resonance imaging (MRI) is not as popular as CT due to blurring and low spatial resolution (5). However, MRI may be a promising method if a strong soft tissue contrast in the abdomen can be achieved. Diffusion-weighted wholebody imaging with background body signal suppression (DWIBS) images are acquired using multiple-signal averaging, pre-pulse fat suppression and heavy diffusion weighting during free breathing (6). DWIBS is based on diffusion-weighted imaging (DWI) that visualizes and assesses the random movement of water at the molecular level (Brownian motion) (7,8). An advantage of DWIBS is that it provides a strong contrast of cancerous against surrounding non-cancerous tissues, which is useful for the detection, staging and monitoring of the response to therapy (9). A major limitation of DWIBS is that anatomical analysis may be difficult at times (10,11).

show abstract

Section: Discussionmentioning

confidence: 79%

Diffusion-weighted whole-body imaging with background body signal suppression/T2-weighted image fusion of gastrointestinal cancers

Tomizawa

Shinozaki

Fugo

et al. 2016

Molecular and Clinical Oncology

View full text Add to dashboard Cite

show abstract

“…Magnetic resonance imaging (MRI) is an auspicious method for depicting various gastric wall layers and the differentiation of tumor tissue from fibrosis [157]. The accuracy for the proper evaluation of the T-stage is between 64-88% [158]. MRI in T-staging was compared with CT, and the accuracy was rather higher for MRI, however, this difference was only proven to be statistically significant in two studies: 73% for MRI versus 67% for helical CT [159] and 81% for MRI versus 73% for spiral CT [160].…”

Section: Imaging Strategiesmentioning

confidence: 99%

Gastric Cancer: Epidemiology, Risk Factors, Classification, Genomic Characteristics and Treatment Strategies

Machlowska

Baj

Sitarz

et al. 2020

IJMS

915

573

View full text Add to dashboard Cite

Gastric cancer (GC) is one of the most common malignancies worldwide and it is the fourth leading cause of cancer-related death. GC is a multifactorial disease, where both environmental and genetic factors can have an impact on its occurrence and development. The incidence rate of GC rises progressively with age; the median age at diagnosis is 70 years. However, approximately 10% of gastric carcinomas are detected at the age of 45 or younger. Early-onset gastric cancer is a good model to study genetic alterations related to the carcinogenesis process, as young patients are less exposed to environmental carcinogens. Carcinogenesis is a multistage disease process specified by the progressive development of mutations and epigenetic alterations in the expression of various genes, which are responsible for the occurrence of the disease.

show abstract

“…In total, 18 prospective studies describing the diagnostic performance of MRI in determining tumor detection and stage are described in Table 1. [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] Data on accuracy, sensitivity, specificity, predictive values, and over-and understaging are included. All studies used histopathology as reference standard.…”

mentioning

confidence: 99%

“…48 The accuracy for correct assessment of T-stage varied from 64 to 88%. 32,[34][35][36][37][38][39][40][41][42][43][44][45][46][47] With the addition of DWI to anatomical MRI (T1W and T2W) in one study, an increase of 7% in the accuracy of T-staging was reported. 35 The accuracy for overall T-staging was significantly better for T2W, DCE and DW-MRI combined, than for T2W with only one of the functional sequences (either DCE or DW-MRI).…”

mentioning

confidence: 99%

Imaging strategies in the management of gastric cancer: current role and future potential of MRI

Borggreve

Goense

Brenkman

et al. 2019

The British Journal of Radiology

View full text Add to dashboard Cite

Gastric cancer is the fifth most common malignancy in the world, with nearly one million new cases of gastric cancer diagnosed every year. 1 Curative treatment of gastric adenocarcinoma consists of partial or total resection of the stomach combined with lymphadenectomy. 2 Over the last years, multimodality treatment strategies such as neoadjuvant chemo(radio)therapy, perioperative chemotherapy and adjuvant chemotherapy have gained importance in the treatment of gastric cancer by improving the likelihood of a radical tumor resection, disease free survival and overall survival. 3-8 Unfortunately, the overall 5 year survival rate still remains poor (35-45%). 4,9 Accurate staging of gastric cancer allows for selection of the most appropriate therapy, minimizes unnecessary surgery and maximizes the likelihood of benefit from the selected treatment. After initial diagnosis by gastroscopy with tumor biopsy, diagnostic work-up can consist of endoscopic ultrasonography (EUS), computed tomography (CT) and 18 F-fluorodeoxyglucose positron emission tomography (18 F-FDG PET). However, these techniques all have their limitations. EUS is an invasive, highly operator-dependent technique and does not detect distant metastases. 10,11 CT exposes patients to ionizing radiation and has poor soft-tissue contrast. 18 F-FDG PET is impaired by the fact that not all gastric carcinomas are 18 F-FDG-avid (avidity ranging from 42-96%) and has a low spatial resolution. 12 Historically, the role of magnetic resonance imaging (MRI) in gastric cancer has been limited, since relatively long acquisition times and technical challenges of peristaltic motion and respiration artifacts resulted in poor imaging quality. 13,14 With the continuous technical improvements in MRI scanning, including fast imaging techniques, (respiratory) motion compensation techniques, use of anti peristaltic agents and the introduction of functional MRI

show abstract

Clinical value of magnetic resonance imaging in preoperative T staging of gastric cancer and postoperative pathological diagnosis

Cited by 11 publications

References 16 publications

Diffusion-weighted whole-body imaging with background body signal suppression/T2-weighted image fusion of gastrointestinal cancers

Diffusion-weighted whole-body imaging with background body signal suppression/T2-weighted image fusion of gastrointestinal cancers

Gastric Cancer: Epidemiology, Risk Factors, Classification, Genomic Characteristics and Treatment Strategies

Imaging strategies in the management of gastric cancer: current role and future potential of MRI

Contact Info

Product

Resources

About