Clinical value of peripheral blood microRNA detection in evaluation of SOX regimen as neoadjuvant chemotherapy for gastric cancer

Tan, Bibo; Yong, Li; Duan, Yan; Fan, Li; Zhao, Qun; Li, Renjie; Wang, Dong; Nan, Jun

doi:10.1002/jcla.22363

Cited by 21 publications

(20 citation statements)

References 27 publications

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“…Although surgery is considered as the mainstay of curative treatment, more than 50% patients with locally advanced GC recur even after complete resection [10]. Accordingly, investigators have demonstrated that neoadjuvant chemotherapy has been widely used in the treatment of advanced GC [11]. However, the effectiveness of neoadjuvant chemotherapy in patients with GC remains unpredictable.…”

Section: Introductionmentioning

confidence: 99%

Relationship between microRNA-27a and efficacy of neoadjuvant chemotherapy in gastric cancer and its mechanism in gastric cancer cell growth and metastasis

Cheng

et al. 2019

Bioscience Reports

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Objective: The aim of the present study is to investigate the relationship between microRNA-27a (miR-27a) and the efficacy of neoadjuvant chemotherapy in gastric cancer (GC) and its mechanism in the growth and metastasis of GC cells. Methods: The expression of miR-27a in serum of 74 GC patients received neoadjuvant chemotherapy was detected by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). Clinical value and prognosis of miR-27a expression in predicting the efficacy of neoadjuvant chemotherapy in GC were evaluated. Besides, GC cells with low miR-27a expression were transfected with miR-27a mimics, and cells with high miR-27a expression were transfected with miR-27a inhibitors and secreted frizzled-related protein 1 (SFRP1) siRNA. A series of experiments were applied for the determination of cell viability, invasion and migration of GC cells. Results: After neoadjuvant chemotherapy, the expression of miR-27a in serum of GC patients decreased significantly. Additionally, the expression of miR-27a in GC cell line was significantly higher than that in normal gastric mucosa cell line. Meanwhile, after down-regulating the expression of miR-27a in GC cells, the mRNA and protein expression of SFRP1 increased, the proliferation rate of cells slowed down, and the ability of invasion and migration decreased. Furthermore, combined with low expression of miR-27a and SFRP1, the proliferation rate of GC cells increased and the ability of invasion and migration increased. Conclusion: Collectively, our study highlights that the high expression of miR-27a indicates the poor efficacy and prognosis of neoadjuvant chemotherapy in GC patients. Down-regulation of miR-27a can inhibit the growth and metastasis of GC cells via up-regulation of SFRP1.

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Section: Introductionmentioning

confidence: 99%

Relationship between microRNA-27a and efficacy of neoadjuvant chemotherapy in gastric cancer and its mechanism in gastric cancer cell growth and metastasis

Cheng

et al. 2019

Bioscience Reports

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“…Increasing evidence uncovered non‐coding RNAs (ncRNAs), including microRNAs (miRNAs), long non‐coding RNAs (lncRNAs), circular RNAs (circRNAs), and transfer RNAs (tRNAs), could be used in GC diagnosis and prognosis . Some altered ncRNAs played a crucial role in the regulation of malignant phenotypes of tumor .…”

Section: Discussionmentioning

confidence: 99%

“…Zhu et al identified that tiRNA‐5034‐GluTTC‐2 might be responsible for a marker for GC diagnosis. Tan et al established that detection of miR‐145 and miR‐185 might be helpful for predicting adverse reactions and effectiveness of SOX regimen against GC . Recent reports illustrated that circ_0067582, circ_0005758, circ_0000467 and circ_0000181 could suggest a role in GC carcinogenesis, and be potential indicators in screening GC .…”

Section: Discussionmentioning

confidence: 99%

“…The detection of piRNA-1245 in GJ could be a new avenue for differentiating GC from healthy people. [24][25][26][27][28][29] Some altered ncRNAs played a crucial role in the regulation of malignant phenotypes of tumor. 24 Mo et al elucidated that lncRNA RP11-555H23.1 showed an important role in the occurrence of GC, and used as a new marker of GC.…”

Section: Accumulating Literatures Showed That Alternation Of Non-codingmentioning

confidence: 99%

“…Tan et al established that detection of miR-145 and miR-185 might be helpful for predicting adverse reactions and effectiveness of SOX regimen against GC. 27 Recent reports illustrated that circ_0067582, circ_0005758, circ_0000467…”

Section: Accumulating Literatures Showed That Alternation Of Non-codingmentioning

confidence: 99%

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Gastric juice piR‐1245: A promising prognostic biomarker for gastric cancer

Zhou

Liu

Meng

et al. 2019

Clinical Laboratory Analysis

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Background: Emerging reports demonstrated that PIWI-interacting RNAs (piR-NAs) played an indispensable role in tumorigenesis. However, it still remains elusive whether piR-1245 in gastric juice specific in stomach could be employed as a biomarker for gastric cancer (GC). The present work is aiming at exploring the possibility of piR-1245 in gastric juice as a potential marker to judge for diagnosis and prognosis of gastric cancer. Methods:Gastric juice was collected from 66 GC patients and 66 healthy individuals.Quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR) was employed to measure the levels of piR-1245 expression. Then, the pattern of piR-1245 expression in gastric juice was determined between GC patients and healthy individuals. A receiver operating characteristic (ROC) curve was constructed for distinguishing GC from healthy individuals.Results: Gastric juice piR-1245 levels in GC were higher than those of controls (P < .0001). The value of area under ROC (AUC) was 0.885 (sensitivity, 90.9%; specificity, 74.2%; 95% confidence interval, 0.8286 to 0.9414). High gastric juice piR-1245 expression was signally correlated with tumor size (P = .013) and TNM stage (P = .001). GC patients with high piR-1245 expression in gastric juice exerted a poorer overall survival (OS) (P = .0152) and progression-free survival (PFS) (P = .013). COX regression analysis verified that gastric juice piR-1245 expression was an independent prognostic risk variable for OS (P < .05). Conclusions:The current study suggested that piR-1245 in gastric juice had the potential to be a useful biomarker for GC detection and prognosis prediction. K E Y W O R D Sbiomarker, gastric cancer, gastric juice, piR-1245, PIWI-interacting RNA

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miR‐212 as potential biomarker suppresses the proliferation of gastric cancer via targeting SOX4

Shao

Zhang

et al. 2020

Clinical Laboratory Analysis

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Clinical value of peripheral blood microRNA detection in evaluation of SOX regimen as neoadjuvant chemotherapy for gastric cancer

Abstract: Patients with GC at advanced stages had aberrant miRs expressions. Detection of miR-145 and miR-185 expression may assist to predict effectiveness and adverse effects of SOX regimen as neoadjuvant chemotherapy.

Cited by 21 publications

References 27 publications

Relationship between microRNA-27a and efficacy of neoadjuvant chemotherapy in gastric cancer and its mechanism in gastric cancer cell growth and metastasis

Relationship between microRNA-27a and efficacy of neoadjuvant chemotherapy in gastric cancer and its mechanism in gastric cancer cell growth and metastasis

Gastric juice piR‐1245: A promising prognostic biomarker for gastric cancer

miR‐212 as potential biomarker suppresses the proliferation of gastric cancer via targeting SOX4

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