Clinical Value of the Forced Expiratory Time Measured during Auscultation

Rosenblatt, Gerald; Stein, Martin H.

doi:10.1056/nejm196208302670903

Cited by 28 publications

(15 citation statements)

References 11 publications

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“…The mean age of the asthmatic subjects was 34 (range with an average interval from the time of the initial symptoms of asthma of 7 yr. Assessment of clinical activity was based on intensity of symptoms and quantity of medication. In addition, respiratory function was routinely monitored by auscultation measuring the duration of forced expiration as described by Rosenblatt and Stein (11). According to these authors there is a very good correlation between this measurement and the 1 s forced expiratory velocity (FEV1),' and we are in complete agreement.…”

Section: Methodsmentioning

confidence: 74%

Alterations in Cyclic Adenosine Monophosphate Metabolism in Human Bronchial Asthma. I. LEUKOCYTE RESPONSIVENESS TO β-ADRENERGIC AGENTS

Parker¹,

Smith²

1973

J. Clin. Invest.

282

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A B S T R A C T In an effort to better define the role of P-adrenergic blockade in human bronchial asthma, peripheral blood leukocytes and lymphocytes from individuals with this condition were studied for possible alterations in cyclic AMP metabolism. Using a previously described radioimmunoassay to measure cyclic AMP, cells from asthmatic subjects were shown to have a highly significant decrease in their cyclic AMP response to 8-adrenergic agents (isoproterenol, norepinephrine, and epinephrine) by comparison with normal control cells. The alteration in responsiveness was most marked at the time of severe active asthma and returned toward normal during periods of clinical remission. Evidence was presented to indicate that the reduced response in cells from asthmatic individuals was not due to marked alterations in the proportion of T and B lymphocytes. Five normal volunteers were treated with an oral bronchodilator preparation containing theophylline and ephedrine over a 2 wk period without a significant change in the lymphocyte cyclic AMP response.These results provide unambiguous evidence for altered adrenergic responsiveness in bronchial asthma and indicate that purified peripheral blood lymphocytes should be a suitable in vitro system for further elucidation of the abnormality.Despite the reduction in catecholamine responsiveness in the asthmatic population as a whole, major altera-

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Section: Methodsmentioning

confidence: 74%

Alterations in Cyclic Adenosine Monophosphate Metabolism in Human Bronchial Asthma. I. LEUKOCYTE RESPONSIVENESS TO β-ADRENERGIC AGENTS

Parker¹,

Smith²

1973

J. Clin. Invest.

282

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“…Both Roy, Chapin, and Favre (1955) and Comroe (1955) associated a long FET with airways obstruction. This idea was developed by Rosenblatt and Stein (1962) and by Lal, Ferguson, and Campbell (1964), who showed that, of simple spirometric tests, FET correlated best with FEV,/FVC. As the concept of small airways disease developed, both McFadden and Linden (1972) and Cochrane et al (1974a) suggested that FET might be a useful index of small airways obstruction in the patient with normal spirometry.…”

Section: Discussionmentioning

confidence: 99%

Forced expiratory time--its reliability as a lung function test.

Macdonald¹,

Cole²,

Seaton³

1975

Thorax

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. (1975). Thorax, 30, The time taken for a forced expiration can be measured easily with stopwatch and stethoscope. Over the last 30 years many observers have been attracted by this simplicity and have proposed a number of uses for forced expiratory time (FET) as a lung function test. Recently, McFadden and Linden (1972) and Cochrane et al. (1974a) have drawn attention to FET as a possible measurement of obstruction to airways of less than 2 mm internal diameter. Both groups suggest a good correlation between FET and other tests of small airways obstruction. Since smokers appear to develop small airways obstruction before standard spirometry becomes abnormal (McFadden and Linden, 1972), a simple small airways test might show which smokers are most likely to develop chronic airways obstruction (Cochrane et al., 1974b) and be of use in epidemiological surveys. Previous tests of small airways disease-frequency dependence of compliance (Macklem, 1972), closing volume (McCarthy et al., 1972), and maximal expiratory flow at 50% of forced vital capacity (McFadden and Linden, 1972)

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“…Rosenblatt and Stein (1962) [24] found that FET as was accurate in identifying both individuals with clinically relevant obstructive pulmonary disease and those without such disease. Lal et al (1964) [12] , having selected FET as cutoff point as 5 s, yielded a sensitivity of 87% and a specificity of 100%.…”

Section: Discussionmentioning

confidence: 99%

“…INTRODUCTION The concept of using the time of forced exhalation (FE) to recognize bronchial obstruction is not new. An increase in FE time (FET) due to bronchial obstruction was noticed approximately fifty years ago [24] . The diagnostic capabilities of both auscultated FET (FET as ) and spirometric FET (FET s ) have been studied.…”

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confidence: 99%