Clinical values of left ventricular mechanical dyssynchrony assessment by gated myocardial perfusion SPECT in patients with acute myocardial infarction and multivessel disease

Cho, Sang-Geon; Jabin, Zeenat; Park, Ki Seong; Kim, Jahae; Kang, Sae-Ryung; Kwon, Seong; Jeong, Gwang‐Woo; Song, Minchul; Kim, Jong Sang; Cho, Jae Yeong; Kim, Hyun Kuk; Song, Ho‐Chun; Min, Jung‐Joon; Bom, Hee‐Seung

doi:10.1007/s00259-016-3542-y

Cited by 19 publications

(18 citation statements)

References 26 publications

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“…These results indicate that post-MI LV systolic dyssynchrony is related not only to global systolic function but also to ESV as well as regional systolic function decline (SMS, STS). Although the factors affecting BW and SD in GMMI phase are not exactly the same, both of them can be used to determine the presence of LV systolic dyssynchrony and assess the prognosis of patients with MI 22 .…”

Section: Discussionmentioning

confidence: 99%

“…The reconstructed short-axis GMMI images were displayed in the polar map format after normalized to the maximum activity and analyzed using a 17-segment model. Tracer uptake was quantitatively analyzed and categorized on a 4-point scale 4 , 22 : Point 0 was defined as tracer activity >75% (normal, viable); Point 1 as tracer activity = 50–75% (minimal scar); Point 2 as tracer activity = 25–50% (moderate scar); and Point 3 as tracer activity <25% (extensive scar). The number of viable (normal, score 0) segments per pig was noted.…”

Section: Methodsmentioning

confidence: 99%

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Role of Gated Myocardial Glucose Metabolic Imaging in Assessing Left Ventricular Systolic Dyssynchrony after Myocardial Infarction and the Influential Factors

Shao

Wang

Tian

et al. 2018

Sci Rep

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In this study, we investigated the role of gated myocardial glucose metabolic imaging in assessing left ventricular (LV) systolic dyssynchrony after myocardial infarction (MI) and explored the influencing factors. Bama mini-pigs were divided into normal group and MI group and subjected to gated myocardial metabolic imaging (GMMI) and gated myocardial perfusion imaging (GMPI). The phase bandwidth (BW), standard deviation (SD) and the latest activation site of left ventricle were obtained using program Cedars QGS. The results showed that (1) BW and SD obtained in GMMI and GMPI showed significant correlation in pigs with MI, but not in the normal pigs, (2) BW and SD obtained in GMMI and GMPI had good consistency in both normal pigs and MI pigs, (3) GMMI and GMPI had a 66.7% identity in determining the latest activation site of left ventricle in the normal pigs and 77.8% identity in determining the latest activation site of left ventricle in pigs with MI. Multivariate stepwise regression analysis showed that total perfusion deficit and summed motion score were independent factors affecting BW and SD in GMMI. In conclusion, phase analysis of GMMI images could objectively reflect LV systolic dyssynchrony resulted from interactions of multiple factors.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Role of Gated Myocardial Glucose Metabolic Imaging in Assessing Left Ventricular Systolic Dyssynchrony after Myocardial Infarction and the Influential Factors

Shao

Wang

Tian

et al. 2018

Sci Rep

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“…[26] In a small population of patients with acute MI and multivessel disease who had undergone successful revascularisation of the culprit arteries, stress phase SD and stress histogram BW were independent predictors of events, which suggests an intriguing application of phase analysis. [27]…”

Section: Mpi Niche Parametersmentioning

confidence: 99%

Behind Traditional Semi-quantitative Scores of Myocardial Perfusion Imaging: An Eye on Niche Parameters

2019

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The evaluation of stress-induced myocardial perfusion defects by non-invasive myocardial perfusion imaging (MPI) modalities has a leading role in the identification of coronary artery disease, and has excellent diagnostic and prognostic value. Non-invasive MPI can be performed using conventional and novel gamma cameras or by PET/CT. New software has allowed novel parameters that may have a role in the identification of early marks of cardiac impairment to be evaluated. We aim to give an overview of niche parameters obtainable by single photon emission CT (SPECT) and PET/CT MPI that may help practitioners to detect initial signs of cardiac damage and identify new therapy targets. In particular, we summarise the role of left ventricular geometry indices for remodelling, phase analysis parameters to evaluate mechanical dyssynchrony, the concept of relative flow reserve in the evaluation of flow-limiting epicardial stenosis, vascular age and epicardial adipose tissue as early markers of atherosclerotic burden, and emerging parameters for the evaluation of myocardial innervation, such as the total defect score.

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“…In the last 13 years, we have a new tool in the area of nuclear cardiology called analysis of left ventricle synchrony. Since 2005, several articles [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] have been published in relation to the normal cut-off values (Table 1), and diagnosis and prognosis (Table 2). From a physiological point of view, the study of the mechanical synchronization of the ventricles is very complex.…”

Section: See Related Article Pp 1650-1658mentioning

confidence: 99%

Analysis of ventricular synchrony: A complex puzzle

Romero-Farina

Aguadé-Bruix

2019

Journal of Nuclear Cardiology

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Clinical values of left ventricular mechanical dyssynchrony assessment by gated myocardial perfusion SPECT in patients with acute myocardial infarction and multivessel disease

Abstract: LVMD measured by GMPS showed added prognostic value in acute MI with multivessel disease. GMPS could serve as a comprehensive evaluation imaging tool in patients with acute MI and multivessel disease.

Cited by 19 publications

References 26 publications

Role of Gated Myocardial Glucose Metabolic Imaging in Assessing Left Ventricular Systolic Dyssynchrony after Myocardial Infarction and the Influential Factors

Role of Gated Myocardial Glucose Metabolic Imaging in Assessing Left Ventricular Systolic Dyssynchrony after Myocardial Infarction and the Influential Factors

Behind Traditional Semi-quantitative Scores of Myocardial Perfusion Imaging: An Eye on Niche Parameters

Analysis of ventricular synchrony: A complex puzzle

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