The present study investigated the effectiveness of simulation based training programme regarding paediatric basic life support on knowledge and skill of nursing students in selected College of Nursing, Kottayam. A quantitative, pre experimental one group pre-test design was used for this study. The conceptual framework used was Modified Daniel L. Stufflebeam's Evaluation Model. Forty-five samples were selected by simple random sampling from Govt. College of Nursing, Kottayam. Tools used were socio personal data sheet, structured knowledge questionnaire for assessing knowledge and paediatric basic life support skill assessment checklist for assessing skill of nursing students. Simulation based training programme regarding paediatric basic life support was given after pre-test for three consecutive days for the samples in three groups. After one week, reinforcement of the training was given to each group of students. A post test was conducted after 15 days of simulation based training programme for each group of students. The results of the study revealed that, simulation based training programme had statistically significant effect on knowledge (p<0.05) and skill (p<0.05) of nursing students regarding paediatric basic life support. Study also revealed that there was no significant correlation between knowledge and skill of nursing students regarding paediatric basic life support. As a conclusion, simulation based training programme is effective in improving the knowledge and skill of nursing students regarding paediatric basic life support.