Clinical Without Histopathological Manifestations of Inflammation in a Patient With Primary Intraorbital Optic Nerve Sheath Meningioma

Abstract

A 28-year-old man with a biopsy-proven benign intraorbital optic nerve sheath meningioma developed recurrent clinical manifestations of ipsilateral retrobulbar inflammation 9 years after undergoing postoperative radiation therapy. Debulking of the tumor 11 years after the original surgery again revealed no pathologic signs of inflammation. Whether growth of tumor, surgery, radiation, or edema triggered the inflammatory manifestations is unclear. Our case affirms that primary optic nerve meningiomas may rarely cause episodic manifestations resembling those of idiopathic orbital inflammation that resolve with corticosteroid treatment.

Secretory Meningiomas of the Orbit

“…Clinically, patients with SOMs typically present with headaches, focal retroorbital pain, and a clinical triad of proptosis, visual field defects and ophthalmoplegia (Shrivastava et al, 2005). One case was associated with clinically significant retrobulbar inflammation and aggressive behavior (Lessell et al, 2007).…”