Clinical zinc and copper deficiencies in cattle of western Sudan

Damir, H. Abu; Barri, M. E. S.; Hassan, S. M. El; Tageldin, Mohammed H.; Wahbi, Ammar; Idris, O. F.

doi:10.1007/bf02239647

Cited by 14 publications

(4 citation statements)

References 5 publications

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“…Results of this study was compatible with Bedwal et al, (1994) who stated that zinc, copper and selenium have significant roles in maintaining good health condition in farm animals as deficiency of these trace elements in our study results in a case of calf ill-thriftiness, this also was in agreement with Damir et al, (1988) who reported that low blood copper and zinc concentrations in growing animals result in general weakness, stunted growth and anemia.…”

Section: Discussionsupporting

confidence: 92%

Trace Elements Status and Antioxidants Profile in Ill-thrift Buffalo Calves

Ismael¹,

El-Sayed²,

Metwally³

et al. 2015

AJVS

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The goal of the present study was to evaluate some trace element concentrations and the activity of antioxidant systems in ill-thrift calves. A total number of (52) buffalo-calf was subjected to study. Out of them, (37) buffalo-calves had poor coat, poor general body condition score which constituted the ill-thrift group. The remained animals (15) were clinically healthy and kept as control group. Complete blood picture, trace elements profile, serum calcium, phosphorus & magnesium , blood urea nitrogen (BUN) , creatinine, some liver function parameters and total antioxidants capacity were evaluated. Results showed a significant reduction in the blood serum concentration of copper, cobalt, iron, selenium and zinc associated with normocytic normochromic anemia. Also a significant reduction in the activity of total antioxidants value was evident in ill-thrift calves. While levels of serum calcium, phosphorus and magnesium , blood urea nitrogen, creatinine and liver function parameters showed non-significant changes. In conclusion, a state of sub-optimal growth (ill-thrift) in buffalo-calves was largely attributed to trace element deficiency, in particular copper, cobalt, iron, selenium and zinc deficiency that may cause reduction in the total antioxidant capacity, with a lower ability to reduce oxidative compounds.

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Section: Discussionsupporting

confidence: 92%

Trace Elements Status and Antioxidants Profile in Ill-thrift Buffalo Calves

Ismael¹,

El-Sayed²,

Metwally³

et al. 2015

AJVS

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“…Frequently, no signs of clinical copper deficiency are seen in studies with zebu cattle despite severely inadequate Cu supply based on recommended levels for B. taurus cattle (Roeder, 1980;Faye et al, 1991;Dermauw et al, 2013b). Other studies suggest that there might be a difference in response to the same diet between the local zebu cattle and B. taurus crossbred cattle (Friot, 1973;Damir et al, 1988).…”

Section: Introductionmentioning

confidence: 99%

A disparate trace element metabolism in zebu (Bos indicus) and crossbred (Bos indicus × Bos taurus) cattle in response to a copper-deficient diet1

Dermauw

Cuyper

Duchateau

et al. 2014

Journal of Animal Science

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Copper deficiency is a commonly diagnosed problem in cattle around the globe. In Jimma, Ethiopia, 8 zebu (Bos indicus) and 8 zebu × Holstein Friesian cross (Bos taurus × Bos indicus) heifers were used in an 11-wk study to investigate breed type differences and effects of Cu deficiency on concentrations of trace elements in plasma and edible tissues as well as mRNA expression of Cu-related genes. Heifers were fed a grass diet (6.4 ± 0.2 [SEM] mg Cu/kg DM) supplemented with 1 mg Mo/kg DM in wk 1 to 4 and 2 mg Mo/ kg DM in wk 5 to 11, with blood samples collected every 2 wk and tissue collection postmortem. Plasma, liver, kidney, and semitendinosus and cardiac muscle were analyzed for Zn, Cu, Fe, Se, Mo, Co, and Mn. Expression of mRNA Cu-related genes was measured in aorta (lysyl oxidase [LOX] ) as well as the Se-related glutathione peroxidase 1 (Gpx1). Zebu cattle maintained initial plasma Cu concentrations just below the threshold value for deficiency, whereas crossbred cattle gradually became severely Cu deficient over time (P < 0.001). In contrast, plasma Zn and Co were greater in zebu cattle at the onset of the trial but became similar to crossbred cattle towards the end of the trial (P < 0.001). Liver Cu (P = 0.002) and Fe (P 0.001), kidney Se (P < 0.001), and kidney and cardiac muscle Co (P 0.001) concentrations were greater in zebu than in crossbred cattle. Increased hepatic mRNA expression of the Cu regulatory genes Atp7b, Ctr1 (P = 0.02), CCS (P = 0.03), and Cox17 (P = 0.009) and Cu-related Sod1 (P = 0.001) as well as the Se-related Gpx1 (P 0.001) were greater in zebu than in crossbred cattle. However, duodenal mRNA expression of DAO (P = 0.8) and Mt1a (P = 0.2) and aortic expression of LOX (P = 0.8) were not different. Both the differences in Cu status indices (plasma and liver concentrations) and hepatic mRNA expression of Cu regulatory genes point to the possibility of a more efficient use of dietary Cu in B. indicus as compared to B. taurus × B. indicus cattle resulting in greater sensitivity to Cu deficiency in B. taurus crossbred cattle. initial plasma Cu concentrations just below the threshold value for deficiency, whereas crossbred cattle gradually became severely Cu deficient over time (P < 0.001). In contrast, plasma Zn and Co were greater in zebu cattle at the onset of the trial but became similar to crossbred cattle towards the end of the trial (P < 0.001). Liver Cu (P = 0.002) and Fe (P ≤ 0.001), kidney Se (P < 0.001), and kidney and cardiac muscle Co (P ≤ 0.001) concentrations were greater in zebu than in crossbred cattle. Increased hepatic mRNA expression of the Cu regulatory genes Atp7b, Ctr1 (P = 0.02), CCS (P = 0.03), and Cox17 (P = 0.009) and Cu-related Sod1 (P = 0.001) as well as the Se-related Gpx1 (P ≤ 0.001) were greater in zebu than in crossbred cattle. However, duodenal mRNA expression of DAO (P = 0.8) and Mt1a (P = 0.2) and aortic expression of LOX (P = 0.8) were not different. Both the differences in Cu status indices (plasma and liver concentrations) and hepatic mRNA ...

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“…Copper deficiency is wide spread and the pathological feature are well documented in cattle, sheep, goats and other ruminants (Underwood 1977;Mills 1983;McDowell 1985;Abu Damir et al 1988;Ivan et al 1990; Ali and Al-Noaim 1992;Hastings and Gascoyne 1992). In the camel, copper deficiency threshold was first proposed by Tartour (1975) in Western Sudan and this was confirmed by Abu Damir et al (1983) and by Faye and Bengoumi (1997).…”

Section: Introductionmentioning

confidence: 91%

Copper status in breeding and racing camels (Camelus dromedarius) and response to cupric oxide needle capsules

Damir

Abbas²,

Ali

2008

Trop Anim Health Prod

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Copper was determined in the blood of breeding camels, camel calves and racing camels to evaluate copper status in these animals in UAE. Low blood copper concentrations were reported in newly born camel calves (100%) and calves 2-4 months old (68%), breeding camels at early (55.6%) and at mid lactation (48%) and at late pregnancy (69%). This is attributed to the low copper and high sulfate in the Rhodes grass which is the only diet offered to the breeding camels. On the other hand only 9.7% of racing camels showed low copper levels. This is because copper is routinely offered to racing camels when their blood copper is low. Cupric oxide needle capsules orally administered at the rate of 8 g per adult camel was effective in elevating blood copper from 7.083 micromol/L at day zero to 10.074 micromol/L at day 28 after dosing.

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Clinical zinc and copper deficiencies in cattle of western Sudan

Cited by 14 publications

References 5 publications

Trace Elements Status and Antioxidants Profile in Ill-thrift Buffalo Calves

Trace Elements Status and Antioxidants Profile in Ill-thrift Buffalo Calves

A disparate trace element metabolism in zebu (Bos indicus) and crossbred (Bos indicus × Bos taurus) cattle in response to a copper-deficient diet1

Copper status in breeding and racing camels (Camelus dromedarius) and response to cupric oxide needle capsules

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