Clinically evidenced unilateral dissociation of saccades and pursuit eye movements

Onofrj, Marco; Iacono, Diego; Luciano, A L; Armellino, K; Thomas, Astrid

doi:10.1136/jnnp.2003.025163

Cited by 5 publications

(2 citation statements)

References 17 publications

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“…It is likely that other structures, such as the INC, were simultaneously involved in these cases. Monocular vertical SGP is more difficult to understand, but is occasionally seen ( 35 ). A specific condition called double elevator palsy results in impairment of both elevator muscles (superior rectus and inferior oblique) in one eye.…”

Section: Clinical Features Of Sgpsmentioning

confidence: 99%

Clinical Approach to Supranuclear Brainstem Saccadic Gaze Palsies

2017

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Failure of brainstem supranuclear centers for saccadic eye movements results in the clinical presence of a brainstem-mediated supranuclear saccadic gaze palsy (SGP), which is manifested as slowing of saccades with or without range of motion limitation of eye movements and as loss of quick phases of optokinetic nystagmus. Limitation in the range of motion of eye movements is typically worse with saccades than with smooth pursuit and is overcome with vestibular–ocular reflexive eye movements. The differential diagnosis of SGPs is broad, although acute-onset SGP is most often from brainstem infarction and chronic vertical SGP is most commonly caused by the neurodegenerative condition progressive supranuclear palsy. In this review, we discuss the brainstem anatomy and physiology of the brainstem saccade-generating network; we discuss the clinical features of SGPs, with an emphasis on insights from quantitative ocular motor recordings; and we consider the broad differential diagnosis of SGPs.

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Section: Clinical Features Of Sgpsmentioning

confidence: 99%

Clinical Approach to Supranuclear Brainstem Saccadic Gaze Palsies

2017

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“…Patients were videoed and photographed in order to quantify follow-up evaluations and in patients with ELR ocular motility was assessed as part of the routinal neurological examination and with methods reported elsewhere [9]. Conjugate gaze deficit was found only in PSP patients.…”

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confidence: 99%