Clinically healthy overweight and obese dogs differ from lean controls in select CBC and serum biochemistry values

Radakovich, Lauren B.; Truelove, Matthew P.; Pannone, Stephen C.; Olver, Christine S.; Santangelo, Kelly S.

doi:10.1111/vcp.12468

Cited by 20 publications

(23 citation statements)

References 20 publications

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“…Obese dogs evaluated in the present study were younger (up to 10 years old) than obese dogs assessed in previous studies (up to 15 years old) [19,20]. It is possible that the excess of body fat has not yet caused an inflammatory process as intense as that observed by these authors [19,20]. With the maintenance of the disease and over time, more evident leukocytes and coagulogram alterations could be observed, besides the increase of plasma fibrinogen.…”

Section: Discussionmentioning

confidence: 45%

“…In group 2, the higher value of plasm fibrinogen concentration, associated with lower lymphocyte count, may suggest an early-stage inflammatory process, even in dogs in good condition. Obese dogs evaluated in the present study were younger (up to 10 years old) than obese dogs assessed in previous studies (up to 15 years old) [19,20]. It is possible that the excess of body fat has not yet caused an inflammatory process as intense as that observed by these authors [19,20].…”

Section: Discussionmentioning

confidence: 54%

“…dogs. In another research, dogs with BCS ≥ 7 had the leukocytes count and plasma protein concentrations more elavated than dogs with BCS 4-6 [19]. The dogs of group 1 and 2 did not present alterations in coagulogram, due to normal values for platelets, PT, aPTT, CT and fibrinogen.…”

Section: Discussionmentioning

confidence: 86%

“…Alterations in leukocytes [19] and the coagulogram [20] of overweight or obese dogs were related to a low intensity inflammatory state, evidenced by the increase of inflammatory markers, such as interleukin 6 and c reactive protein, in serum of dogs [20]. Plasma fibrinogen is also an inflammatory marker, which may be increased in obese dogs [31].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Coagulation Parameters in Dogs with Overweight or Obesity

Barbosa

Martins

Rosário

et al. 2019

Acta Scientiae. Vet.

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Background: Hemostatic alterations have already been well characterized in humans with body fat excess, being included in the list of obesity related comorbidities. Overweight and obesity are common in dogs; however, there is little information about the blood coagulation parameters in dogs with these conditions. The aim of this study was to compare hematological and coagulation parameters between lean dogs and overweight or obese dogs, including platelets count; prothrombin time (PT); activated partial thromboplastin time (aPTT), coagulation time (CT) and plasma fibrinogen concentration. Materials, Methods & Results:A total of 22 dogs (aged 1 to 10 years, neutered) were evaluated, 10 of them presented ideal body condition score (BCS 4-5) and formed the group 1 (control) and 12 were overweight or obese (BCS 7-9) and formed the group 2. The dogs were submitted to clinical evaluation and then to blood collection for the following laboratory tests: blood count (performed on automatic analyzer), quantification of plasma proteins by refractometry, determination PT, aPTT and plasma fibrinogen concentration using specific commercial kits, and CT by Lee-White method. Compared to group 1, group 2 presented a lower leukocytes and lymphocytes counts (P < 0.05) and a higher concentration of plasma fibrinogen (P = 0,026), but compatible with reference values. No difference was observed in the erythrogram, platelets count, total plasma protein concentration, PT, aPTT and CT between the groups. BCS was negatively correlated with leukocytes (r = -0.45) and lymphocytes (r = -0.60) counts and positively with plasma fibrinogen concentration (r = +0.56). Discussion: The reduction in lymphocytes led to a lower leukocytes count in the dogs of group 2. The migration of peripheral blood lymphocytes to adipose tissue has been reported in the early phase of the inflammatory process induced by obesity and could justify the reduction of circulating lymphocytes in overweight or obese dogs evaluated in this study; however, cytopathological assessment of adipose tissue was not performed. Fibrinogen has to be converted to fibrin for clot formation, so the concentration of this plasma protein is an important parameter for the evaluation of hemostasis. However, there are reports of increase in plasma fibrinogen as a result of infammatory processes. In group 2, formed by dogs with overweight or obese, the higher value of plasm fibrinogen concentration, associated with lower lymphocyte count, may suggest an early-stage inflammatory process. Similar results were described in obese humans, but also evidenced in obese dogs. Supporting this suggestion, the correlation analysis indicates that the higher the body fat excess (estimated by the BCS), the higher the fibrinogen concentration and the lower the lymphocyte count in evaluated dogs. Despite the higher concentration of plasma fibrinogen in group 2, no change was observed in the hemostasis of overweight or obese dogs, due to the normal values for platelets count, PT, aPTT and CT, excluding a hyperco...

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Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of Coagulation Parameters in Dogs with Overweight or Obesity

Barbosa

Martins

Rosário

et al. 2019

Acta Scientiae. Vet.

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“…It is known that more than half of domestic dogs are either overweight or obese in the United States [1]. In recent years, obesity-related diseases have been a serious issue for both veterinarians and pet owners [1][2][3]. Since canine obesity can contribute to the induction of complex physiologic states accompanied by chronic, low-grade inflammation, just as in humans [1][2][3], many researchers have analyzed the influence of functional foods on animals.…”

Section: Introductionmentioning

confidence: 99%

Effects of a Watermelon Extract Beverage on Canine Lipid Metabolism and Urine Crystals

Miyai¹

2018

AVS

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Previous report showed that watermelon consumption has an anti-obesity effects in rats. The purpose of this study is to examine the effects on body weight, body fat percentage, serum biochemical data, serum adipokine concentrations (leptin, adiponectin, and resistin), urine specific gravity and sediments when 12 dogs were given watermelon extract beverage instead of water for 3 months. Those data were all assessed before the study period and again at 1.5 and 3 months. Although there were no remarkable changes in most of these parameters, a significant decrease in serum leptin concentrations at 1.5 and 3 months. Calcium oxalate and struvite crystals were observed in the urinary sediment in five dogs; although their urine specific gravities remained >1.040 throughout, the number of urinary crystals had decreased by the end of the 3-month period. Morphological components were not found in the urinary sediment of the other five dogs; their urine specific gravities were also >1.040 before the study period and at 1.5 months, but these had decreased to <1.040 at 3 months. These results suggested that drinking the watermelon extract beverage reduced serum leptin levels and inhibited the formation of urine crystals such as calcium oxalate and struvite crystals in dogs.

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Hematology of Dogs

McCourt¹,

Rizzi²

2022

Schalm's Veterinary Hematology

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Clinically healthy overweight and obese dogs differ from lean controls in select CBC and serum biochemistry values

Cited by 20 publications

References 20 publications

Evaluation of Coagulation Parameters in Dogs with Overweight or Obesity

Evaluation of Coagulation Parameters in Dogs with Overweight or Obesity

Effects of a Watermelon Extract Beverage on Canine Lipid Metabolism and Urine Crystals

Hematology of Dogs

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