Clinically Manifesting vs. Incidental Sellar Masses—A Comprehensive Comparative Study

Pituitary Incidentalomas – Where Do We Go From Here?

“…Furthermore, some PI on presentation may turn out to have previously undiagnosed visual field abnormalities. [7] In a recent analysis, [10] we found that PIs were around 20% more likely to present with previously undiagnosed visual field abnormalities than those who presented with clinical evidence of pituitary dysfunction. Can dizziness, which was a common indication for imaging, be associated with partial loss of vision in this group remains a tantalizing research question.…”

“…Indeed, our own data [7] showed that almost 30% of patients with PI had EDITORIAL J Cancer Allied Spec 2016;2(2):1 biochemical evidence of hormonal loss at presentation including growth hormone deficiency, hypogonadism, secondary hypothyroidism, secondary hypoadrenalism and even diabetes insipidus. Although no study has formally compared the need for surgery in this group, our own analysis [10] showed that almost a third (32%) of PI eventually required surgical management as opposed to 46% of the clinically manifesting pituitary adenomas. Whether long-term outcomes of PI with or without treatment are different, remain to be studied.…”