This study examines the impact of financial strain, social support, and negative interactions on depressive symptoms among African Americans and the role of mastery as a mediator in these relationships. Structural equation modeling and baseline data from the Americans' Changing Lives Study were used to test these relationships among a sample of African Americans aged 50 to 96 years (N = 583). Findings illustrate the mechanistic pathways whereby financial strain is associated with depressive symptoms. Moreover, the study findings give further credence to the notion that positive and negative aspects of social relationships are distinctive with respect to social status factors, financial strain, and their relationship to depressive symptoms. This research suggests that mastery is an important mechanism linking negative interaction to mental health. The collection of findings provide a number of provocative departures from research conducted primarily using White samples and identifies important areas of intervention with older African Americans.Keywords negative interactions; social support; mastery; mental health Although a growing body of research has documented how negative social interactions (e.g., conflict, demands, and broken promises) and social support affect mental health status, there are two issues that deserve increased attention. First, this body of literature has offered much less by way of explanatory mechanisms. Specifically, missing from past empirical studies on negative interactions are the mechanisms that shape the conditions under which social support and negative interactions impact mental health. A second issue that deserves more attention involves the role of negative interactions among ethnically and racially diverse populations. For example, we know little about how negative interactions affect the health and well-being of older African Americans. The lack of studies on this topic among African Americans and other racial minority groups fosters an assumption that social theories and models are conceptually and functionally equivalent across diverse groups. Consequently, much of the work on this topic may not be generalizable to other racial or ethnic groups.Despite the valuable and informative work that has been done in this area to date, there is added value in examining the heterogeneity within the older African American population.