Clinically Significant Danazol-Carbamazepine Interaction

Zielinski, Janusz J.; Lichten, Edward M.; Haidukewych, Dan

doi:10.1097/00007691-198703000-00005

Cited by 29 publications

(3 citation statements)

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“…Interactions with other drugs must be considered, especially in long‐term use. For example, danazol can potentiate the effects of anticoagulants [45], elevate the concentration of carbamazepine [46] or lead to insulin resistance [47] and thus impair the effectiveness of antidiabetic drugs.…”

Section: Androgen Derivativesmentioning

confidence: 99%

Hereditary angioedema: an update on available therapeutic options

Maurer

Magerl

2010

J Deutsche Derma Gesell

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Summary There is no cure for hereditary angioedema (HAE). Therapeutic approaches consist of symptomatic therapy for acute attacks, short‐term prophylaxis before surgery, and long‐term prophylaxis for those with frequent and severe attacks. In Germany, C1‐INH concentrate and icatibant are licensed for acute therapy. C1‐INH concentrate, which is obtained from human plasma, is administered intravenously to restore the deficient C1‐INH activity. This therapy, which has been available for decades, is effective and well‐tolerated. Batch documentation is required by German law. The synthetic decapeptide icatibant is administered subcutaneously. It competes with bradykinin, the responsible inducer of edema formation, for binding to the bradykinin B2 receptor. Icatibant is also effective and well‐tolerated, even on repeated administration. An additional human C1‐inhibitor, a recombinant human C1‐inhibitor and the recombinant inhibitor of kallikrein ecallantide are currently under development. There are no licensed treatment options available in Germany for long‐ and short‐term prophylaxis. Androgen derivatives are established in long‐term prophylaxis. However, they are associated with many adverse effects, some of which are severe. Many drug interactions also limit their use. They are contraindicated in pregnancy, lactation, for children and in cases of prostate cancer. Antifibrinolytics have fewer adverse effects but are also less effective than androgens. They are contraindicated in thromboembolic disease and impaired vision. If androgen therapy has too negative an effect on quality of life, it may be worth reducing the dose or discontinuing therapy entirely and treating attacks with acute therapy.

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Section: Androgen Derivativesmentioning

confidence: 99%

Hereditary angioedema: an update on available therapeutic options

Maurer

Magerl

2010

J Deutsche Derma Gesell

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“…An overview of additional contraindications, using the androgen derivative dana‐zol as an example, is provided in Table 5. Drug interactions are also to be considered, especially if androgen derivatives are taken over a long period of time (Table 6) [40–44].…”

Section: Limitations/contraindications/drug Interactionsmentioning

confidence: 99%

Long‐term prophylaxis of hereditary angioedema with androgen derivates: a critical appraisal and potential alternatives

Maurer

Magerl

2010

J Deutsche Derma Gesell

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Summary Androgen derivatives are regarded as standard in the long‐term prophylaxis of swelling attacks in patients with hereditary angioedema (HAE). Because of their relatively slow onset of action, they are not suitable for acute therapy. Long‐term prophylaxis with androgen derivatives must be regarded critically, especially on account of their androgenic and anabolic effects, some of which are severe. The risk of adverse events increases with the daily dose and the duration of treatment. Thus, treatment always calls for close monitoring of patients with regard to potential adverse events. In addition, androgens are subject to numerous contraindications and they show interactions with a large number of other drugs. Off‐label use, doping issues, clarification of reimbursement and the need to import the androgen derivatives, which are no longer marketed in Germany, result in additional effort for the treating physician in terms of logistics and time involved. In symptomatic treatment of acute attacks the intravenous substitution of C1‐INH and – since 2008 – subcutaneous administration of icatibant are available. The two substances are well tolerated and their effect occurs rapidly and, when the diagnosis has been confirmed, reliably. In the light of these two treatment options for controlling acute attacks, prophylactic treatment of HAE patients with androgen derivatives such as danazol should be reassessed. Patients might benefit from a dose reduction or the withdrawal of androgen prophylaxis and attacks can be controlled with demand‐oriented acute treatment using C1‐INH or icatibant.

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“…1986), isoniazide (Valsalan andCooper, 1982). danazol (Zielinski et al. 1986), and omeprazole (Naidu e t al.. 1994).…”

Section: Interactions With Other Drugsmentioning

confidence: 99%

Carbamazepine Clinical Pharmacology: A Review

Albani

Riva²,

Baruzzi³

1995

Pharmacopsychiatry

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The tricyclic anticonvulsant carbamazepine is being increasingly used to treat a variety of neuropsychiatric disorders. We review the literature on the drug in neurology, psychiatry, and pharmacology, in order to provide the clinical psychiatrist with a comprehensive reference on carbamazepine pharmacokinetics, toxicity, and drug interactions. We also present an overview of the psychiatric disorders in which carbamazepine has been found, or suggested, to be efficacious.

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Clinically Significant Danazol-Carbamazepine Interaction

Cited by 29 publications

References 0 publications

Hereditary angioedema: an update on available therapeutic options

Hereditary angioedema: an update on available therapeutic options

Long‐term prophylaxis of hereditary angioedema with androgen derivates: a critical appraisal and potential alternatives

Carbamazepine Clinical Pharmacology: A Review

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