Clinically significant infections with organisms of the Streptococcus milleri group

Belko, John S.; Goldmann, Donald A.; Macone, Ann B.; Zaidi, Anita K. M.

doi:10.1097/00006454-200208000-00002

Cited by 59 publications

(68 citation statements)

References 59 publications

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“…[3][4][5] Viridans streptococci are normally considered to be of low virulence even though they can occasionally cause infections such as subacute endocarditis and, some subgroups, in particular Streptococcus intermedius (milleri), even cause invasive pyogenic infections, including brain, pulmonary and abdominal abscesses, and osteomyelitis, in immunocompetent individuals. 6,7 Relatively little is known about the immunopathogenesis of these diseases. A role for cell wall components of Streptococcus mitis in induction of shock through a TNFa-dependent pathway was suggested in an experimental murine model.…”

Section: Discussionmentioning

confidence: 99%

Viridans streptococcal septicaemia in neutropenic patients: role of proinflammatory cytokines

Ihendyane

Sparrelid

Wretlind

et al. 2004

Bone Marrow Transplant

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Section: Discussionmentioning

confidence: 99%

Viridans streptococcal septicaemia in neutropenic patients: role of proinflammatory cytokines

Ihendyane

Sparrelid

Wretlind

et al. 2004

Bone Marrow Transplant

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“…Although all the viridans group streptococci have the propensity to cause severe invasive infections, SAG organisms are increasingly isolated from clinically significant specimens and are associated with significant morbidity and mortality (Belko et al, 2002;Bert et al, 1998;Ruoff, 1988).…”

Section: Introductionmentioning

confidence: 99%

“…What is known is that the SAG are frequently pathogenic and cause contiguous or distant infections including pyogenic brain and liver abscesses and, rarely, bacteraemia and endocarditis (Belko et al, 2002;Bert et al, 1998;Stelzmueller et al, 2009). Nearly all isolates are susceptible to penicillin, while resistance has been encountered to newer agents, including daptomycin (Palacio et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Nearly all isolates are susceptible to penicillin, while resistance has been encountered to newer agents, including daptomycin (Palacio et al, 2011). Treatment of infections due to S. anginosus almost always involves source control via surgical excision or abscess drainage along with antimicrobial therapy as appropriate (Belko et al, 2002;Bert et al, 1998;Stelzmueller et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Clinical and microbiological outcomes in patients with Streptococcus anginosus group bacteraemia identified through use of a rapid microarray assay

Wenzler

Chandrasekaran

Salvador

et al. 2015

Journal of Medical Microbiology

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Limited data exist evaluating outcomes in patients with serious Streptococcus anginosus group infections, particularly bacteraemia. A retrospective, single-centre cohort study was conducted to characterize potential risk factors along with clinical and microbiological outcomes in patients with S. anginosus group bacteraemia (SAGB). Adult inpatients with SAGB identified using the Verigene Gram-positive blood culture assay between March 2013 and April 2014 were included. Patients aged j18 or .89 years, those with SAGB identified at an outside facility and those who were incarcerated were excluded. Differences between groups were explored using a Wilcoxon rank-sum test, x 2 test, Student's t-test or Fisher's exact test as appropriate and a two-tailed P value of j0.05 was considered statistically significant. The 34 patients who met the inclusion criteria were 57¡14 (mean¡SD) years old and had a median Charlson co-morbidity index of 4 [interquartile range (IQR) 1-6] and 10 (29 %) were immunosuppressed at baseline. Almost half (47 %) had received antibiotics in the previous 90 days. Twelve (35 %) patients had gastrointestinal malignancies and the commonest source of bacteraemia was the gastrointestinal tract (53 %). The primary species responsible for SAGB was S. anginosus (68 %), and overall susceptibility to penicillin was 91 %. Patients were most often treated with a b-lactam/blactamase inhibitor combination (36 %) for a duration of 8 (IQR 4-13) days. Length of stay (LOS) and infection-related LOS were 10 (IQR 5-17) and 9 (IQR 4-12) days, respectively. Twenty [59 %] patients achieved a clinical cure, while 29 (85 %) achieved a microbiological cure. Four (12 %) patients died and one patient was readmitted within 30 days. In the largest cohort of patients with SAGB to date, gastrointestinal malignancies may have been an important risk factor for SAGB, while rapid identification via a microarray assay likely contributed to improved disease recognition and timely pharmacological and non-pharmacological therapy.

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“…En cuanto a su sensibilidad antimicrobiana, el grupo Streptococcus grupo anginosus tiene una buena sensibilidad in vitro y en los reportes clínicos, a penicilina y a cefalosporinas de tercera generación, aunque están surgiendo comunicaciones de resistencia a penicilina que pueden llegar al 33% 1,5 .…”

Section: Introductionunclassified

Sepsis por Streptococcus anginosas originada en cáncer de colon abscedado: Reporte de un caso

D³

et al. 2008

Rev Chil Cir

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RESUMENSe presenta el caso de un paciente, hombre de 74 años, portador de hipertensión arterial crónica y diabetes mellitus Tipo 2, portador de un cáncer de colon derecho recientemente diagnosticado y que tenía planificada cirugía electiva. Es ingresado de urgencia al Hospital del Salvador por un cuadro de calofríos y fiebre alta de tres días de evolución, cuyo estudio descartó foco séptico pulmonar, urinario y otros, incluyendo Ecocardiograma para descartar una endocarditis. Solo se demostraron dos hemocultivos positivos para Streptococcus anginosus, siendo tratado exitosamente con Ceftriaxona y Metronidazol. Es intervenido quirúrgicamente al 7º día, encontrándose un tumor abscedado de colon derecho. Evolución postoperatoria satisfactoria, siendo dado de alta al 5º día del postoperatorio.PALABRAS CLAVE: Streptococcus anginosus, cáncer de colon, sepsis. ABSTRACTWe report a 74 years old hypertensive and diabetic male with a recently diagnosed right colon cancer that consulted in the emergency room for fever and chills lasting three days. He was admitted, two blood cultures were positive for Streptococcus anginosus, treatment with Ceftriaxone and Metronidazole was started and fever subsided after four days of treatment. The surgical exploration showed that the colon cancer was abscessed and was the origin of the sepsis. The patient was discharged in good conditions five days later.

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Clinically significant infections with organisms of the Streptococcus milleri group

Cited by 59 publications

References 59 publications

Viridans streptococcal septicaemia in neutropenic patients: role of proinflammatory cytokines

Viridans streptococcal septicaemia in neutropenic patients: role of proinflammatory cytokines

Clinical and microbiological outcomes in patients with Streptococcus anginosus group bacteraemia identified through use of a rapid microarray assay

Sepsis por Streptococcus anginosas originada en cáncer de colon abscedado: Reporte de un caso

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