Clinicians' Attitudes to Recruitment to Randomised Trials in Cancer Care: A Qualitative Study

Langley, Carole; Gray, Selena; Selley, Sara; Bowie, Cameron; Price, Chris

doi:10.1177/135581960000500307

Cited by 33 publications

(53 citation statements)

References 18 publications

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“…Many studies (23/35) explored recruitment issues within the context of a single RCT [13,[23][24][25][30][31][32][33][36][37][38][39][40]42,44,[46][47][48][51][52][53][54]56], whilst eight provided a synthesis of results from multiple RCTs [26][27][28]41,45,49,50,55]. Four studies sampled healthcare professionals who recruited to RCTs generally, rather than a specific trial [29,34,35,43]. Overall, the quality of these studies was good (see Supplementary [ 9 _ T D $ D I F F ] material), although common methodological issues revolved around whether data analysis was sufficiently rigorous (it was sometimes not clear if saturation was achieved or if multiple researchers had analysed data to enhance reliability of the findings…”

Section: Summary Of Included Papersmentioning

confidence: 99%

“…Recruiters were from urological cancer trials [13,23,25,27,28,40,41,44,55], other cancer trials [24,27,28,32,35,40,44,49,50,52,54,55], mental health [27,28,39,46,50,55], orthopaedics [31,33,38,49,56], diabetes [36,47], vascular surgery [40,49], peripartum trials [37,53], HIV [30], smoking cessation [42], and pressure area care [51]. The majority of studies (32/35) focused on RCTs that were conducted in the UK [13,[24][25][26][27][28][29][31][32]…”

Section: Summary Of Included Papersmentioning

confidence: 99%

“…The majority of studies (32/35) focused on RCTs that were conducted in the UK [13,[24][25][26][27][28][29][31][32][33][34][35][36][37][38][39][40][41][43][44][45][46][47][48][49][50][51][52][53][54][55][56].…”

Section: Summary Of Included Papersmentioning

confidence: 99%

“…Studies consisted mostly of interviews or focus groups with those involved in recruitment to RCTs [13,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37]39,[42][43][44][46][47][48][49][50][51][52][53][54][55][56], sometimes alongside interviews with patients who had been offered the opportunity to join the trial [23][24][25][26]33,37]. Several studies audio recorded consultations where recruiters discussed the RCT with eligible patients [13,[24][25][26]31,32,38,40,41,44,45,49,…”

Section: Summary Of Included Papersmentioning

confidence: 99%

“…Awareness and understanding of the particular RCT was also deemed to be important [29,33,39,42,43,54], particularly in terms of the eligibility criteria [34,35,39] and study processes [35,36,39]. Many recruiters felt that receiving regular updates and feedback from the trial team was beneficial [34,35,47], although some found this overwhelming [36]. [25] Feasibility/main study comparing prostatectomy, radiotherapy, and active monitoring for prostate cancer in UK…”

Section: Exploring Facilitators and Barriers To Recruitmentmentioning

confidence: 99%

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Understanding and Improving Recruitment to Randomised Controlled Trials: Qualitative Research Approaches

et al. 2017

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Context: The importance of evidence from randomised trials is now widely recognised, although recruitment is often difficult. Qualitative research has shown promise in identifying the key barriers to recruitment, and interventions have been developed to reduce organisational difficulties and support clinicians undertaking recruitment. Objective: This article provides an introduction to qualitative research techniques and explains how this approach can be used to understand-and subsequently improverecruitment and informed consent within a range of clinical trials. Evidence acquisition: A literature search was performed using Medline, Embase, and CINAHL. All studies with qualitative research methods that focused on the recruitment activity of clinicians were included in the review. Evidence synthesis: The majority of studies reported that organisational difficulties and lack of time for clinical staff were key barriers to recruitment. However, a synthesis of qualitative studies highlighted the intellectual and emotional challenges that arise when combining research with clinical roles, particularly in relation to equipoise and patient eligibility. To support recruiters to become more comfortable with the design and principles of randomised controlled trials, interventions have been developed, including the QuinteT Recruitment Intervention, which comprises in-depth investigation of recruitment obstacles in real time, followed by implementation of tailored strategies to address these challenges as the trial proceeds. Conclusions: Qualitative research can provide important insights into the complexities of recruitment to trials and inform the development of interventions, and provide support and training initiatives as required. Investigators should consider implementing such methods in trials expected to be challenging or recruiting below target. Patient summary: Qualitative research is a term used to describe a range of methods that can be implemented to understand participants' perspectives and behaviours. Data are gathered from interviews, focus groups, or observations. In this review, we demonstrate how this approach can be used to understand-and improve-recruitment to clinical trials. Taken together, our review suggests that healthcare professionals can find recruiting to trials challenging and require support with this process.

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Section: Summary Of Included Papersmentioning

confidence: 99%

Section: Summary Of Included Papersmentioning

confidence: 99%

Section: Summary Of Included Papersmentioning

confidence: 99%

Section: Summary Of Included Papersmentioning

confidence: 99%

Section: Exploring Facilitators and Barriers To Recruitmentmentioning

confidence: 99%

See 3 more Smart Citations

Understanding and Improving Recruitment to Randomised Controlled Trials: Qualitative Research Approaches

et al. 2017

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Cancer screening and aging: Research barriers and opportunities

Gorin

Gauthier

Hay

et al. 2008

Cancer

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Cancer is the second most common cause of death among those aged 65 years, and is a major cause of morbidity. There is some evidence that screening, by detecting precancerous lesions in asymptomatic patients, is effective in reducing cancer-related morbidity and mortality among older men and women. The objectives of the current review article were to identify some of the barriers to and opportunities for research in cancer screening among older individuals. Using expert opinion, the authors developed a taxonomy of barriers to research among those aged 65 years at 3 levels: the macro (policy and population), the organi-

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Impact psychologique de la proposition des essais th�rapeutiques en canc�rologie

Lavau‐Denès

Genet

Vénat-Bouvet

et al. 2004

Revue Francophone de Psycho-Oncologie

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Les patients atteints de cancer auxquels un essai thérapeutique est proposé, subissent un retentissement psychologique majeur. Ils doivent ajuster leurs mécanismes pour accepter ou non le protocole. Nous décrivons 3 cas cliniques de patients. Le temps et la relation médecin-malade sont des atouts dans ce contexte, afin d'obtenir une décision sereine.Abstract: Cancer patients to whom clinical trials are offered suffer major psychological repercussions. They need to adjust their mechanisms so as to be able to decide whether they accept the protocol or not. We describe three clinical cases of patients. In this context, time and the relationship between doctor and patient are important assets for a calm decision to be made.

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Clinicians' Attitudes to Recruitment to Randomised Trials in Cancer Care: A Qualitative Study

Cited by 33 publications

References 18 publications

Understanding and Improving Recruitment to Randomised Controlled Trials: Qualitative Research Approaches

Understanding and Improving Recruitment to Randomised Controlled Trials: Qualitative Research Approaches

Cancer screening and aging: Research barriers and opportunities

Impact psychologique de la proposition des essais th�rapeutiques en canc�rologie

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