Clinico-Epidemiological Analysis of Most Prevalent Parotid Gland Carcinomas in Poland over a 20-Year Period

Žůrek, Michal; Jasak, Kamil; Jaros, Karolina; Daniel, Paul; Niemczyk, Kazimierz; Rzepakowska, Anna

doi:10.3390/ijerph191610247

Cited by 7 publications

(11 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, we also identi ed histological type as a prognostic factor by using the nomogram. Patients with SCC and ACC were more likely to die from MSGC, which was consistent with the study by Zurek et al 32 .…”

Section: Discussionsupporting

confidence: 92%

Development and validation of a novel lymph node classification-based model for predicting survival in major salivary gland cancer

Shen

Gong

Cheng

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Current lymph node (LN) staging is controversial in predicting the survival of major salivary gland cancer (MSGC). Recently, a novel LN staging system for MSGC has been proposed. This study aimed to validate the prognostic value of the novel LN staging system and develop a new LN classification-based nomogram to predict the individualized overall survival (OS) of MSGC patients. Methods A total of 4563 MSGC patients were identified from the Surveillance Epidemiology and End Results (SEER) database (2004–2015). They were further randomly divided into the training and validation cohorts (7:3). OS was estimated by the Kaplan-Meier method, and prognostic factors were assessed using Cox proportional hazards model. Then, a prognostic nomogram predicting the survival of SGC was derived and validated. Finally, the discrimination and calibration of the nomogram were evaluated using C-index, the area under the time-dependent receiver operating characteristic curve (time-dependent AUC), and calibration plots. Decision curve analysis (DCA) was used to compare the clinical practicability between the nomogram and American Joint Committee on Cancer (AJCC) staging system. Results The novel LN staging system was found to be independently associated with OS in MSGC, and it exhibited better discriminatory ability than the current AJCC LN staging system. Meanwhile, a prognostic nomogram based on this staging was formulated. The C-index of the nomogram was 0.793 (95% CI: 0.781–0.805) in the training cohort, which was higher than the C-index of the AJCC staging system (0.707, 95% CI: 0.693–0.721, p < 0.001). And the time-dependent AUC (> 0.8) also indicated that the nomogram had a satisfactory discriminative ability. The calibration plots showed that the nomogram predicted was consistent with the actual observation. Additionally, DCA demonstrated that the nomogram had a better clinical application value than the AJCC staging system. Conclusions The novel SGC-specific LN staging system exhibited an excellent prognostic value for OS in patients with MSGC. And the proposed nomogram based on this LN staging showed better accuracy and applicability in predicting the OS of MSGC patients than the AJCC staging system.

show abstract

Section: Discussionsupporting

confidence: 92%

Development and validation of a novel lymph node classification-based model for predicting survival in major salivary gland cancer

Shen

Gong

Cheng

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Treatment options for recurrent or metastatic ACC include surgery, radiation therapy, chemotherapy, targeted therapy, and immunotherapy. However, the optimal management approach for recurrent or metastatic ACC is still under investigation, and there is no consensus on the best treatment strategy [ 30 , 31 , 32 ]. Overall, the outlook for ACC depends on the individual case and requires a personalized approach to treatment and monitoring.…”

Section: Discussionmentioning

confidence: 99%

Subglottotracheal Adenoid Cystic Carcinoma in a 16-Year-Old Female—A Case Report

Dumitru

Balica

2023

Medicina

View full text Add to dashboard Cite

Cystic adenoid carcinoma (ACC) is a rare malignant epithelial tumor arising from exocrine glands and accounts for only 1% of head and neck cancers. ACCs are common in the fifth and sixth decades of life, predominantly in women, and characterized by slow progression, local aggression, recurrence, and high metastasis. Subglottotracheal ACC is a rare tumor in the pediatric population, with only a few cases reported in the literature. We present a case of a 16-year-old female who was diagnosed with ACC in the subglottic and tracheal region. The patient presented with respiratory failure but without a history of dysphonia, dyspnea, stridor, or dysphagia. The diagnosis was confirmed by a biopsy, and subsequent imaging studies showed a large tumor involving the subglottic and tracheal region. The therapeutic management of this patient has been challenging due to the rarity of this tumor in the pediatric population and the potential long-term complications associated with tumor recurrence and psychological impact. This case highlights the diagnostic and therapeutic challenges in the management of subglottotracheal ACC in children and the importance of a multidisciplinary approach to optimize patient outcomes.

show abstract

“…In most cases of recurrences, RT is also recommended. Recent studies emphasize the role of RT in the management of malignancies of the salivary glands and show improved overall survival in specific subtypes—adenoid cystic carcinoma, adenocarcinoma, high-grade mucoepidermoid carcinoma, and carcinoma ex pleomorphic adenoma [ 48 , 49 ]. Studies show 5- and 10-year survival rates with different salivary gland malignancies at 52–85% and 32–75%, respectively [ 49 – 53 ].…”

Section: Therapeutic and Prognostic Implications Of Correct Diagnosismentioning

confidence: 99%

“…Recent studies emphasize the role of RT in the management of malignancies of the salivary glands and show improved overall survival in specific subtypes—adenoid cystic carcinoma, adenocarcinoma, high-grade mucoepidermoid carcinoma, and carcinoma ex pleomorphic adenoma [ 48 , 49 ]. Studies show 5- and 10-year survival rates with different salivary gland malignancies at 52–85% and 32–75%, respectively [ 49 – 53 ]. The best prognosis is for acinic and adenoid cell carcinoma, and the worst for adenocarcinoma and squamous cell carcinoma, with differences in 5-year survival reaching up to 68% [ 49 ].…”

Section: Therapeutic and Prognostic Implications Of Correct Diagnosismentioning

confidence: 99%

“…Studies show 5- and 10-year survival rates with different salivary gland malignancies at 52–85% and 32–75%, respectively [ 49 – 53 ]. The best prognosis is for acinic and adenoid cell carcinoma, and the worst for adenocarcinoma and squamous cell carcinoma, with differences in 5-year survival reaching up to 68% [ 49 ].…”

Section: Therapeutic and Prognostic Implications Of Correct Diagnosismentioning

confidence: 99%

See 1 more Smart Citation

Salivary gland pathologies: evolution in classification and association with unique genetic alterations

Žůrek

Fus

Niemczyk

et al. 2023

Eur Arch Otorhinolaryngol

Self Cite

View full text Add to dashboard Cite

Purpose The correct classification of salivary gland pathologies is crucial for choosing a treatment method and determining the prognosis. Better outcomes are now achievable thanks to the introduction of new therapy approaches, such as targeted therapies for malignant salivary gland tumors. To apply these in clinical routine, a clear classification of the lesions is required. Methods The following review examines all changes from the first World Health Organization (WHO) Classification of salivary gland pathologies from 1972 to fifth edition from 2022. Possible developments in the diagnosis and classification of salivary gland pathology are also presented. Results The current WHO classification is the fifth edition. With the development of new diagnostic methods, based on genetic alterations, it provides insight into the molecular basis of lesions. This has resulted in the evolution of classification, introduction of new entities and reclassification of existing ones. Conclusions Genetic alterations will become increasingly more significant in the identification of salivary gland pathologies in the future. These alterations will be helpful as prognostic and predictive biomarkers, and may also serve as targets for anti-cancer therapies.

show abstract

Clinico-Epidemiological Analysis of Most Prevalent Parotid Gland Carcinomas in Poland over a 20-Year Period

Cited by 7 publications

References 75 publications

Development and validation of a novel lymph node classification-based model for predicting survival in major salivary gland cancer

Development and validation of a novel lymph node classification-based model for predicting survival in major salivary gland cancer

Subglottotracheal Adenoid Cystic Carcinoma in a 16-Year-Old Female—A Case Report

Salivary gland pathologies: evolution in classification and association with unique genetic alterations

Contact Info

Product

Resources

About