BACKGROUND Oral cancer is one of the most common cancers in the world. In India it is the most common cancer among the males; among the females, it is the third most common cancer. The purpose of this study is to retrospectively evaluate the different primary site of occurrence of Oral Squamous Cell Carcinoma (OSCC), its age and gender distribution. METHODS A retrospective descriptive study was conducted in the department of Dental Surgery, Stanley Medical College and Hospital. A total number of 196 patients with histologically confirmed diagnosis of OSCC were selected for the study. The cases were systematically grouped under various sites of OSCC, age and gender and the findings were formulated. RESULTS A total number of 196 patients were diagnosed as OSCC with the male to female ratio of 3:1, buccal mucosa 78 (39.79%) and tongue 77 (39.28%) are the most common sites involved, followed by mandibular alveolus with 13 (6.63%). 7 (3.57%) had primary lesion at maxillary and retromolar trigone respectively. 5 (2.51%) had the lesion in palate and floor of the mouth. Four patients (2.04%) had the lesion in labial mucosa. Highest number of 57 (29.8%) patients was in the age group of 41-50. CONCLUSIONS Oral cancer is one of the major public health problems associated with risk habits commonly involving the buccal mucosa and tongue. It can easily be prevented by conducting awareness programme among the high-risk groups. Prevention and early intervention will reduce the mortality rate of OSCC.