Clinico-haematological Profile of HbE Syndrome in Adults and Children

Tyagi, Seema; Pati, Haraprasad; Choudhry, V. P.; Saxena, Rovin

doi:10.1080/10245330310001638983

Cited by 15 publications

(10 citation statements)

References 3 publications

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“…This high concentration is actually the resultant value of HbE and HbA 2 , both of which have the same electrophoresis zone in the high-performance liquid chromatography method [27,28]. These increased levels (i.e., $40%) are in accordance with previous studies that found levels of 37-71% [29] and 30-70%, respectively [5]. From these values, it can be concluded that HbA 2 levels in HbE/b-thal patients vary between 3% and 6%.…”

Section: Hematological Featuressupporting

confidence: 86%

Modifying effect of XmnI, BCL11A, and HBS1L-MYB on clinical appearances

Rujito

Basalamah²,

Siswandari

et al. 2016

Hematology/Oncology and Stem Cell Therapy

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Section: Hematological Featuressupporting

confidence: 86%

Modifying effect of XmnI, BCL11A, and HBS1L-MYB on clinical appearances

Rujito

Basalamah²,

Siswandari

et al. 2016

Hematology/Oncology and Stem Cell Therapy

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“…Hemoglobin E (HbE) is prevalent mostly in Naga tribes in the Northeast states of India. [31] For the same reasons pattern of NCDs, in which race has been shown to be a risk factor, might differ both in quantity and quality in different STs. This could also explain the regional differences in the prevalence of hypertension in STs in the NNMB report.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and risk factors of hypertension and diabetes in the Katkari tribe of coastal Maharashtra

Deo¹,

Pawar²,

Kanetkar

et al. 2017

Journal of Postgraduate Medicine

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Background and Objectives:Urban and rural India are both going through health epidemiological transition and will soon face huge burden of noncommunicable diseases (NCDs). Information on the status of NCDs in tribals is limited. Although the prevalence of hypertension in scheduled tribes (STs) has been studied in several states by the National Nutrition Monitoring Bureau, tribe-specific data are very scanty. The objective of this study was to generate data on the status of hypertension and diabetes, the two objectively measurable NCDs in Katkaris, the dominant ST in the Raigad district of coastal Maharashtra.Methods:The study was conducted in 410 adult Katkaris (women 219) of both sexes of ≥18 years of age in three adjoining tehsils of the district. Using the Institution Review Board approved protocol; information was obtained on sociodemographic parameters, educational level, dietary pattern, and substance abuse. Prevalence of overweight, hypertension, and diabetes was measured using standard field-based procedures and techniques.Results:Katkaris, who are mostly landless manual laborers, subsist on a protein-poor, imbalanced diet. About half of women and one-third of men have body mass index (BMI) <18.5 kg/m2, an indication of undernutrition. On the other hand, about 2% of participants were obese (BMI ≥30 kg/m2). The overall prevalence of hypertension and diabetes was 16.8% and 7.3%, respectively. Hypercholesterolemia was recorded in about 3% of the participants.Interpretation and Conclusions:Prevalence of diabetes and hypertension in Katkaris is still lower than that of urban and rural populations, closer to the latter. This may be due to the absence of known risk factors such as obesity, sedentary lifestyle, and hyperlipidemia in this community. Fast acculturation of the STs suggests that NCDs will soon become a major health issue in them too. It is time to launch a multicentric national study to gather baseline information on the status of NCDs in STs.

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“…Of these variants, Hb E is prevalent in the north-eastern states [910]. The largest series of >90,000 CE-HPLC records from West Bengal has revealed heterozygous Hb E in 2.68%, Eβ in 1.56%, and Hb E in 0.39% individuals who underwent thalassemia screening [10].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the characteristics of two hemoglobin variants, Hb D-Iran and Hb E, eluting in the Hb A2 window

et al. 2017

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BackgroundCation exchange-high performance liquid chromatography (CE-HPLC) is most commonly used to evaluate hemoglobin (Hb) variants, which elute in the Hb A2 window. This study aimed to assess prevalence of an uncommon Hb variant, Hb D-Iran, and compare its red cell parameters and peak characteristics with those of Hb E that commonly elutes in the Hb A2 window.MethodsGenerally, we assess abnormal Hb using CE-HPLC as the primary technique along with alkaline and acid electrophoresis. All cases with Hb A2 window >9%, as assessed by CE-HPLCs during 2009–2013, were selected.ResultsTwenty-nine cases with Hb D-Iran variant were identified—25 heterozygous, 2 homozygous, 1 compound heterozygous Hb D-Iran/β-thalassemia, and 1 Hb D-Iran/Hb D-Punjab. Overall prevalence of Hb D-Iran was 0.23%. Compared to patients with Hb E, those with Hb D-Iran had significantly higher Hb (12.1 vs. 11.3 g/dL, P=0.03), MCV (82.4 vs. 76.4 fL, P=0.0044), MCH (27.9 vs. 25.45 pg, P =0.0006), and MCHC (33.9 vs. 33.3 g/dL, P=0.0005). Amount of abnormal Hb (40.7 vs. 26.4%, P=0.0001) was significantly higher while retention time (3.56 vs. 3.70 min, P=0.0001) was significantly lower in Hb D-Iran than in Hb E.ConclusionHb D-Iran peak can be easily missed if area and retention time of the Hb A2 window are not carefully analyzed. To distinguish between variants, careful analysis of peak area and retention time is sufficient in most cases and may be further confirmed by the second technique—alkaline electrophoresis.

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Clinico-haematological Profile of HbE Syndrome in Adults and Children

Cited by 15 publications

References 3 publications

Modifying effect of XmnI, BCL11A, and HBS1L-MYB on clinical appearances

Modifying effect of XmnI, BCL11A, and HBS1L-MYB on clinical appearances

Prevalence and risk factors of hypertension and diabetes in the Katkari tribe of coastal Maharashtra

Comparison of the characteristics of two hemoglobin variants, Hb D-Iran and Hb E, eluting in the Hb A2 window

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