Clinico-Histopathological Correlation of Granulomatous Lesions of Skin: A Retrospective Analysis of 111 Cases

Abstract

Introduction: Granulomatous skin lesions present as wide spectrum of clinical conditions where diagnosis with signicant accuracy is possible only through the histopathological examination of biopsy samples. The study was to a Aims and objective: ssess the frequency of granulomatous skin lesions and their pattern in relation to their clinical ndings and histopathology. The retrospective study was conducted Material & Methods: in the department of pathology of our institute. The data related to the age, gender, clinical presentation, and the biopsy ndings was analyzed. Results: Amongst 111 histologically proven cases of granulomatous lesions, there was male preponderance. The commonest age group involved was between 21-40 years. The common primary clinical types were plaque, nodule, and macule present in 42.34%, 31.53% and 15.31% cases respectively. The most common diagnosis was leprosy (54.05%), followed by tuberculosis (39.63%). Among the leprosy cases, borderline tuberculoid and borderline lepromatous were the most common types. Histologically, all lesions showed epithelioid cell granulomas, the commonest type being tuberculoid granuloma. This study reafrms that histopathology is Conclusions: a fundamental tool to diagnose granulomatous skin diseases. Type of granulomas, their pattern and associated features suggest about the diagnosis. Infective diseases (leprosy and cutaneous tuberculosis) are still the most common granulomatous skin diseases.