Clinico-Laboratory Profile and Drug Sensitivity Pattern in Urinary Tract Infection of Children in a Tertiary Care Hospital

Abstract

Background: Urinary tract infection (UTI) is common in children. About 7% girls and 2% of boys suffer from symptomatic, culture positive UTI by 6 years of age. These children present with poor feeding, irritability, vomiting, fever, abdominal pain or failure to thrive. Now a days antibiotic resistance is a global problem which hampers appropriate treatment of urinary tract infection in children. This study was done to see clinical profile, common pathogens and their drug sensitivity pattern in UTI. cases were included. History was taken properly. Diagnosis of UTI was confirmed by urinalysis and culture sensitivity (C/S). All informations were recorded in preformed data sheet.Results: Usual presentations of UTI were fever, abdominal pain, vomiting, constipation, urinary complaints, poor feeding, labial adhesion, jaundice, excessive straining. Out of 200 cases 168 were culture positive. Group III age group (> 1year-5 year) showed higher rate of UTI. UP to one year of age males were more affected than female and beyond one-year females were more affected than male. Most common isolated uropathogen was Escherichia coli. Most sensitive drugs for the pathogen were Imipenem and meropenem (89.39%) -Injectable form and nitrofurantoin (73.48 %)-Oral form.Conclusion: Presentation of UTI in case of young infant is different from older children. Clinical suspicion is important for early detection of UTI. Before starting antimicrobial therapy, we must do urinalysis and culture sensitive test to prevent recurrent UTI.

Clinico-Laboratory Profile And Drug Sensitivity Pattern In Urinary Tract Infection Of Children In A Tertiary Care Hospital

“…Amikacin was the drug that tolerated bacteria the least. This outcome is consistent with the work of Paul et al [30]…”

“…The variable and non-specific signs and symptoms of infection in infants and young children, however, complicate the epidemiology of UTI [3] . Infants with UTIs may experience a variety of different, non-specific symptoms, including fever, sepsis, lethargy, extended jaundice, haematuria, poor feeding, vomiting, diarrhoea, irritability, failure to grow, and murky or odorous urine [4] . Although UTI is rarely linked to fatality still it is a significant cause of morbidity.…”