Clinico-Pathological Characteristics of Colorectal Cancer among Young Subjects Aged 30 and Under in Tropical Areas: Retrospective Comparative Study Over Ten Years of Clinical Practice in Cameroon

Andoulo, Ankouane; Mathurin, Kowo; Etienne, Atenguena Obalemba; William, Ndjitoyap Ndam Antonin; Bekolo, Winnie; Donrielle, Dontsi; Fiacre, Eloumou Bagnaka Servais

doi:10.31080/asgis.2021.04.0309

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“…Given that the life expectancy in SSA country is low, the screening policy should be earlier than in western countries [6]. Some CRC are diagnosed before 30 years [9]. In this study, a male predominance with a sex ratio of 1.7 was highlighted.…”

Section: Discussionmentioning

confidence: 80%

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Predictive values of an immunological fecal occult blood test for the diagnosis of colorectal cancer compared using colonoscopy in symptomatic patients in Yaounde (Cameroon)

Jovanka,

Wilson,

Winnie

et al. 2024

BMC Gastroenterol

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Introduction The predictive value of immunological fecal occult blood (iFOB) testing for the screening of colorectal cancer has been well described in the Western world. However, its relevance in Sub-Saharan Africa (SSA) is not well evaluated. It could be altered by the other causes of lower gastrointestinal bleeding such as parasitic infections. The aim of this study was to highlight the performance of an iFOB test for the prediction of colorectal cancer (CRC) during colonoscopy in SSA. Methodology We conducted an analytical cross-sectional study in two digestive endoscopic centers of Yaoundé (Cameroon) from the 1st July to the 31 November 2022. Patients presenting with an indication for colonoscopy without any overt gastrointestinal bleeding were included. Sociodemographic and clinical data were collected. All consenting patients underwent a qualitative immunologic occult test through the iFOB test before colonoscopy. Data were analyzed using SPSS version 23.0 software. The performance of the iFOB test for the diagnosis of CRC during colonoscopy was evaluated in terms of sensitivity (Se), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV). Results We included 103 patients during the study period with a male predominance and a sex ratio of 1.7. The median age [IQR] was 52 [38—65] years (range 1 – 84 years). The most common colonoscopic lesions were polyps in 23 patients (22.3%), CRC in 17 patients (16.5%) and hemorrhoids in 15 patients (14.6%). Patients testing positive for iFOB test accounted for 43.7% (45 patients). Among these patients, 31.1% (14 patients) had a CRC. The Se of the occult blood test for CRC detection was calculated to be 82.3% (95%CI: 56.7—96.2); the Sp was 63.9% (95% CI: 53—74); the PPV was 31.1% (95% CI: 24—39) and the NPV was 94.8% (95% CI: 86.6—98.1). Conclusion The iFOB test has a good NPV, but a poor PPV for the diagnosis of CRC in our study.

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Section: Discussionmentioning

confidence: 80%

“…In SSA, the population is poor, with a life expectancy of 50-60 years. The age of onset of CRC seems to be younger with an average age of 50 years old, with many patients aged less than 30 years [8,9]. The screening policy cannot be the same with those in developed countries [6].…”

Section: Introductionmentioning

confidence: 99%