Clinico-Pathological Correlation of Hysterectomy Specimens for Abnormal Uterine Bleeding in Peri Menopausal Women

Mandal, Dr Sujeet Kumar

doi:10.18535/jmscr/v5i1.125

Cited by 3 publications

(5 citation statements)

References 6 publications

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“…In simple hyperlasia the gland stromal ratio is maintained, where as in complex hyperplasia gland stromal ratio is increased [37]. 15.5% showed disordered proliferative endometrium in AUB in the present study, which is comparable to study by Doraisamy Saraswathi et al(20.5%) and Sajitha et al(12.2%) [23,27] 24.03% of AUB cases showed adenomyosis which is similar comparable to sujeet et al [19].…”

Section: Discussionsupporting

confidence: 89%

“…[29]. Most common age for AUB correlated with many other previous studies [19,27,31]. AUB is common in the perimenopausal age, [27,32,33,34] WHO defines perimenopausal age group as the period between 2 to 8 years preceding menopause and one yearafter the last mensus [35].…”

Section: Discussionmentioning

confidence: 56%

“…25.3% cases had adenomyosis. Pevious studies reported similar findings ie.,leiomyoma and adenomyosis as the most common histopathological finding in their studies [5,10,13,15,16,19]. Khriesat et al reported adenomyosis as the most common finding in hysterectomy specimens with 37%.…”

Section: Discussionmentioning

confidence: 99%

“…Most common histopathology in AUB patients was due to endometrial pathology followed by adenomyosis and leiomyoma in the present study. Study by Sujeet et al showed leiomyoma, DUB and adenomyosis as the common cause for AUB [19]. Doraisamy Saraswathi et al reported DUB, disordered proliferative endometrium as the most common histopathological abnormality in AUB [27].…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathological spectrum of hysterectomy specimens in a tertiary care hospital- A review of 826 cases

Bosco

Sarada

2020

Trop J Pathol Microbiol

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Introduction: Hysterectomy is one of the most common surgeries performed for common gynaecological indications, but less frequently done for tumors of female genital tract. Abnormal uterine bleeding (AUB) is one of the most common indications for hysterectomy. Histopathology is essential to confirm these common causes, but also helps to identify rare causes and to rule out malignancy. This study aims to anaylse the age pattern, clinical indications, clinicopathological correlation of hysterectomy cases along with distribution, causes and histopathological pattern of endometrial lesions in AUB. Material and Methods: The present study is a retrospective study done at Trichy SRM medical college hospital with hysterectomies done between January 2018 to November 2019 been included in the study. Clinical and Histopathological details were recorded, analysed and compared. Results: Of the 826 cases, Total abdominal hysterectomy was the most common surgery. The age varied from 21 to 85 with fourth decade as the most common age. Fibroid uterus and AUB were the most common clinical indication. Histopathology revealed leiomyoma as the most common diagnosis. About 95.5% cases correlated with clinical diagnosis. Of the 258 AUB cases, 100 had pure endometrial pathology and 31 cases showed combined endometrial and other pathologies. Totally 76 cases of endometrial hyperplasia were identified and 65 presented with AUB. About 11.6% AUB patients had malignancy and endometrial carcinomacomprised of 3.9% cases. Conclusion: Histopathological evaluation is essential to substantiate the clinical findings, identify missed pathologies, establishing a definitive etiology thereby aiding effective treatment of the pathology.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinicopathological spectrum of hysterectomy specimens in a tertiary care hospital- A review of 826 cases

Bosco

Sarada

2020

Trop J Pathol Microbiol

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“…Of the 126 subjects, AUB-L was identified as the most common histopathological diagnosis in 53.17% of subjects, followed by AUB-A (36.5%), AUB-P (30.15%), and AUB-M (15.87%). This HPE diagnosis aligns with Neena Y et al [21] , Mohammed N et al [8] , Mandal SK et al [22] , Mishra D et al [4] , and Misra B et al [15] studies, where AUB-L consistently emerged as the predominant HPE diagnosis. For the AUB-M component, our study revealed a prevalence of 15.87%, a finding comparable to the study conducted by Misra ~ 84 ~ B et al [15] .…”

Section: Discussionsupporting

confidence: 84%

A study to correlate clinical with pathological findings in abnormal uterine bleeding (AUB)

Avasthi,

Bhavani,

Gilhotra

et al. 2023

Int. J. Clin. Obstet. Gynaecol.

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Introduction: Abnormal uterine bleeding (AUB) poses a significant health and financial burden, especially in perimenopausal women. Despite the PALM-COEIN classification, gaps persist in correlating clinical and histopathological aspects. Our study, utilizing diagnostic modalities like Ultrasonography, Hysteroscopy, and Endometrial sampling, seeks to enhance diagnostic precision in AUB, contributing to improved management strategies and patient outcomes. Materials and Methods: This descriptive study investigated Abnormal Uterine Bleeding (AUB) in 126 women aged 35 and above at our hospital from September 2019 to February 2021. The study utilized the PALM-COEIN classification system for categorizing AUB causes. Inclusion criteria covered various AUB presentations, while exclusion criteria excluded specific conditions. Data collection involved a structured proforma, and diagnostic interventions encompassed Ultrasonography, Hysteroscopy, and Endometrial sampling. Statistical analysis employed various measures, including the concordance index and Chi-square test, utilizing SPSS 21. Results: This hospital-based study enrolled 126 women presenting with abnormal uterine bleeding (AUB), offering comprehensive insights into their demographic, clinical, and histopathological profiles. The mean age of the cohort was 45.96 years, with a notable concentration in the 40-44.99 age group. The majority resided in urban areas (96.83%) and belonged to the upper middle class (65.87%), with housewives constituting 97.62%. AUB patterns, including irregular bleeding (56.35%) and postmenopausal bleeding (15.87%), were meticulously examined. Comorbidities, predominantly hypertension (31 patients) and hypothyroidism (22 patients), were identified in 60 patients. Ultrasonography revealed Leiomyoma in 54.76% and Adenomyosis in 24.6%. Clinical diagnoses, utilizing the PALM-COEIN classification, highlighted AUB-L as the primary cause (54.76%). Diagnostic modalities such as Hysteroscopy, Hysterectomy, and concordance analyses contributed to enhanced diagnostic precision, emphasizing the multidimensional approach imperative for effective AUB management in clinical practice. Conclusion: Our study underscores the efficacy of the PALM-COEIN classification in correlating clinical and histopathological findings for Abnormal Uterine Bleeding (AUB). Leiomyoma emerged as the primary etiology, showcasing the classification's utility in identifying dual pathologies. Histopathological examination significantly complemented clinical diagnoses, emphasizing the system's value in optimizing patient care.

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Frequency and Spectrum of Non-Malignant Lesions in Abdominal Hysterectomy Specimens

Zehra¹,

Gardezi²,

Shams³

et al. 2021

J. Bahria Univ. Med. Dent. Coll.

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Objective: To determine the histological spectrum of non-malignant lesions in abdominal hysterectomy specimens from women of reproductive age group. Study Design and Setting: This was a descriptive cross-sectional study carried out at a private hospital in Karachi from December 2018 to December 2019. Methodology: The uterine specimens of patients (n=262) between the ages of 24 to 55 years were collected. Hysterectomies done due to any benign uterine disease were included in the study. Hysterectomies due to malignant causes were excluded. Pathological diagnosis was done on light microscopy using routine hematoxylin and eosin staining technique. Data collected during the study period included patient's age, clinical history/diagnosis and histological diagnosis. On receiving the hysterectomy specimens as per protocol, specimens were immediately put in 10% formalin, appropriately labeled for patient’s name, gender, age and procedure. In histopathology lab, grossing of the specimens was done using standard protocols. Frequency and variables were analyzed by using descriptive statistics of SPSS-version 22. Results: Total n=262 hysterectomies were received. Mean age of all the patients was 34.7 years ±7.8. Non-malignant uterine pathologies on histopathology included 124(47.7%) leiomyomas, 52(20%) adenomyosis, 32(12.3%) endometrial polyps, 16(6.2%) endometrial hyperplasia, 6(2.3%) endometritis, 3(1.2%) disordered proliferative endometrium and 1(0.4%) endometrial stromal nodule. Rest of the cases showed normal phases of endometrial cycle. Only two cases (0.76%) out of 262 received as clinically benign uterine disease, were diagnosed as malignant on histopathology. Conclusion: Leiomyoma is the most common uterine pathology diagnosed in clinical setting as well as encountered at histopathological examination followed by Adenomyosis and endometrial polyps in women of reproductive age group in Pakistan.

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Clinico-Pathological Correlation of Hysterectomy Specimens for Abnormal Uterine Bleeding in Peri Menopausal Women

Cited by 3 publications

References 6 publications

Clinicopathological spectrum of hysterectomy specimens in a tertiary care hospital- A review of 826 cases

Clinicopathological spectrum of hysterectomy specimens in a tertiary care hospital- A review of 826 cases

A study to correlate clinical with pathological findings in abnormal uterine bleeding (AUB)

Frequency and Spectrum of Non-Malignant Lesions in Abdominal Hysterectomy Specimens

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