Clinico-pathological features of breast carcinoma in elderly Egyptian patients: A comparison with the non-elderly using population-based data

Zeeneldin, Ahmed A.; Ramadan, Mohamed; Gaber, Ayman; Taha, Fatma

doi:10.1016/j.jnci.2012.10.003

Cited by 43 publications

(39 citation statements)

References 33 publications

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“…Furthermore, the reaction of lawsone 1 with α,β-unsaturated ketones like; chalcone, 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one, 1,5-diphenylpenta-1,4-dien-3-one, 2-benzylidenequinuclidin-3-one, 4-(4-methoxy benzylidene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, 3-benzylideneindolin-2-one, or 2,5-di(benzylidene)cyclopentan-1-one in DMF yielded α-Lapachone drivatives 3-5, 8-10, and 11, respectively. The structures of 4, 5, 8, and 11 were supported by their 13 C NMR spectral data. Their 13 C NMR showed signals for C-4 at 51.02, 40.35, 40.34, and 40.35 ppm, respectively.…”

Section: Resultsmentioning

confidence: 74%

“…The structures of 4, 5, 8, and 11 were supported by their 13 C NMR spectral data. Their 13 C NMR showed signals for C-4 at 51.02, 40.35, 40.34, and 40.35 ppm, respectively. Elucidate the structure of compounds 2, 4, 5, 8, and 11 by 13 C NMR (Fig.…”

Section: Resultsmentioning

confidence: 74%

“…They are also known as potential inhibitors of DNA Topoisonerase [9], in addition to playing an important role against epimastigote and trypomastigote form [10]. Cancer is the major cause of death around the world [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Concise Synthesis and Pharmacological Applications of New α‐Lapachone Analogues

Hamama

Hassanien

Zoorob

2017

Journal of Heterocyclic Chem

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Synthesis of novel 1,4‐naphthoquinones structurally related to α‐lapachone skeleton and its annulated compounds were synthesized from lawsone (2‐hydroxynaphthalene‐1,4‐dione). Pharmacological studies provided indication of biological activities, including effects against hepatocellular carcinoma (HePG‐7) and mammary gland breast cancer (MCF‐7). The molecular structures of the target molecules were examined.

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Section: Resultsmentioning

confidence: 74%

Section: Resultsmentioning

confidence: 74%

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Concise Synthesis and Pharmacological Applications of New α‐Lapachone Analogues

Hamama

Hassanien

Zoorob

2017

Journal of Heterocyclic Chem

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“…Aging together influences treatment and prognosis 3,4 . Increasing lifespan among older Egyptians with breast cancer is expected to rise within the future 2 .Older breast cancer have multiple number of disease 5 . Also, tumor size and nodal involvement increase with age as a result of delayed identification and aggressiveness 6,2 .…”

Section: Breastmentioning

confidence: 99%

Psychological Well-Being of Elderly Women Who Early Survive Breast Cancer and its Associated Factors

Alam

Boughdady

El‐Gilany

2017

IJND

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Background: Diagnosis and treatment of breast cancer (BC) adversely affect the psychological well-being (PWB) of elderly patients. Aim of the study: This study aims to describe the PWB of elderly women-survivors of (BC) and its associated factors. Subjects: A convenient sample of 163 old women undertaken treatment of BC was enclosed within the study. Setting: This study was carried out at Mansoura University hospital (oncology center) in the outpatient clinics. Tools: Data collected included: Socio demographic and clinical data structured interview schedule. Psychological well-being was measured by the Arabic version of Ryff's Psychological Well-Being (RPWB) Scale. Religious activities were measured by the brief Arab religious coping Scale (BARCS). Results: Older women with breast cancer showed highly low mean scores (ranging from 21.7 to 25.6) within the six subscales of PWB. The mean scores of environmental mastery, personal growth, positive relations and purpose in life vary significantly consistent with age groups of the participants, educational level. The mean scores of autonomy, positive relations and self-acceptance showed vital variation consistent with variety of work before retirement. The mean scores of autonomy, environmental mastery, personal growth, life purpose, and self-acceptance vary consistent with income level. On the other hand the mean scores of personal growth, positive relations, and self-acceptance subscales vary significantly consistent with presence or absence of co-morbidities. Religious-coping-activities have vital inverse, weak correlation with autonomy and vital positive, moderate correlations with environmental mastery, positive relations, and self-acceptance. Conclusion: This study concluded that the women with breast cancer have low PWB scores. Several factors are related to variation in PWB. Religious coping improves PWB of elderly women extant breast cancer in posttreatment phase. There is a space for improvement. Recommendations: Special attention should be paid to elderly women with impaired PWB during follow-up visits.

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“…Surveys are published using these Gharbiah data up to 2007 and are limited to specific websites of cancer mainly breasted . (41,42) , and gynecological cancers. (40) None of these geographicallylimited studies and published rates could be studied as representative of Egypt, There is no doubt that cancer like other physiological phenomenon has social and emotional aspects and it is classified in the realm of behavioral sciences.…”

Section: Statistical Data Analysismentioning

confidence: 99%

Emotional Distress Associated with Gynecologic and Breast Cancer in Beni-Suef City

2016

IJSR

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Background: All women are at risk for breast and gynecologic cancer. There is no doubt that breast and gynecologic cancer is a stressful experience by creating heavy psychological trauma for the woman and has great impact on psychological and emotional health of women. Depression and anxiety consider the emotional disturbances which usually associated with cancer. Aim: assess prevalence rate and investigate the emotional effects of gynecologic and breast cancer. Subjects and Methods: For this study, data were collected through in-depth interviews for the convenience of 200 cancers diagnosed female who were admitted in inpatient wards and/or attending to outpatient gynecological and surgery clinics at University Hospital and General Hospital in Beni-Suef city. Results: The findings of this study indicated that, all types of gynecologic and breast cancer women suffered from different degrees of anxiety and depression. Breast, ovarian, cervical, vulval cancers have significant relations with symptoms of depression scale score. Emotional distress symptoms were severe in women aged 30-40 years, the secondary education level. Depression and anxiety symptoms were more observable in housewives, urbanized, nuclear and not crowded families, compared with working, rural, extended and crowded ones. A statistically significant impact of pain related menstruation, surgical intervention and its type and symptoms of depression scale score. Conclusion: Based on the findings of the present study, it can be concluded that, there is a statistically significant association between cancer women and emotional distress symptoms.

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Clinico-pathological features of breast carcinoma in elderly Egyptian patients: A comparison with the non-elderly using population-based data

Abstract: EBC patients in Egypt present with advanced disease and are less likely to receive surgery, radiotherapy or chemotherapy compared to NEBC patients.

Cited by 43 publications

References 33 publications

Concise Synthesis and Pharmacological Applications of New α‐Lapachone Analogues

Concise Synthesis and Pharmacological Applications of New α‐Lapachone Analogues

Psychological Well-Being of Elderly Women Who Early Survive Breast Cancer and its Associated Factors

Emotional Distress Associated with Gynecologic and Breast Cancer in Beni-Suef City

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