Clinico-pathological findings in cattle exposed to chronic bracken fern toxicity

Alenza, María Dolores Pérez; Blanco, José Luis Santiago; Sardón, David; Moreiro, Sanchez; Rodríguez‐Bertos, Antonio

doi:10.1080/00480169.2006.36693

Cited by 20 publications

(5 citation statements)

References 17 publications

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“…Studies show that tumors of the urinary bladder in cattle are of epithelial and mesenchymal origin and are commonly associated with chronic enzootic hematuria, a syndrome caused by prolonged ingestion of bracken fern (21,22). In line with this, the postmortem examination of all the affected animals in the present study showed multiple tumors in the urinary bladder wall, which were either pedunculated or broad with marked areas of bleeding; moreover, histologically, hemangiosarcoma and hemorrhages were observed in the mesenchymal part of the bladder, revealing the presence of tumors (7).…”

Section: Discussionsupporting

confidence: 83%

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Assessment of the occurrence and cause of bloody urine in cattle and management practices in Cheliya, Jibat, and Dire Inchini districts of the West Shewa Zone, Oromia, Ethiopia

Borena,

Sarba,

Eteya

et al. 2024

Preprint

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Background A study was conducted to assess the causes of bloody urine and management practices in cattle from the Cheliya, Jibat, and Dire Inchini districts of the West Shoa Zone, Oromia, Ethiopia. Materials and methods Two kebeles from each of the three districts were selected based on bloody urine case reports, and a total of 215 cattle-owning households were selected for the questionnaire survey. Field observations were performed to screen for possible causes of bloody urine in the study areas. Six animals with symptoms of bloody urine were clinically examined, followed by postmortem and histopathological examinations. Results The questionnaire survey results showed that 72.1% (n = 155) of the households had at least one bloody urine case in their cattle herd. Among the three districts, more bloody urine cases were reported in the Cheliya district (95.0%), compared to 67.4% in Jibat and 53.5% in Dire Inchini. About 33.0% of the households reported the death of at least one cattle due to bloody urine; 58.8% of which were from the households in Cheliya, while 40.8% in Jibat, and 4.7% in Dire Inchini district. The occurrence of bloody urine was related to the dry season, feed shortage, access to bracken fern-infested pasture, and a known history of eating bracken fern. There was a high infestation rate of bracken fern (Pteridium aquilinum) in the grazing areas. All six suspected cattle exhibited chronic wasting and hematuria. Centrifugation of the urine samples revealed hematuria. Postmortem examination revealed petechial hemorrhage, papillomatous formations, thickened areas of mucosa, and white/red nodules on the urinary bladder. Conclusions Severe infestation of the bracken fern in the study areas, chronic hematuria, and wasting and postmortem findings in the bladder were all suggestive of bracken fern poisoning. Therefore, an immediate and integrated approach should be implemented to prevent cattle from accessing infested areas, remove this plant from grazing areas, and replace it with appropriate forage.

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Section: Discussionsupporting

confidence: 83%

“…Moreover, tumors can develop in the gastrointestinal tract. Chronic enzootic hematuria is the most common type of bracken fern poisoning in cattle and is characterized by intermittent hematuria and anemia and other signs, such as acute hemorrhagic syndrome, hemorrhagic diathesis, and upper gastrointestinal tract neoplasia (7,8).…”

Section: Introductionmentioning

confidence: 99%

Assessment of the occurrence and cause of bloody urine in cattle and management practices in Cheliya, Jibat, and Dire Inchini districts of the West Shewa Zone, Oromia, Ethiopia

Borena,

Sarba,

Eteya

et al. 2024

Preprint

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“…In the study by Fletcher and co-workers mentioned above the plasma activity of AST, creatine kinase, GD and GGT were reported to be within reference values and no histological changes were found in the liver. The enzyme levels in cattle with chronic ingestion of bracken are also varying between studies [43,44]. The differences may be related to the different composition and concentration of other compounds present in bracken [20,21].…”

Section: Discussionmentioning

confidence: 99%

Fate of ptaquiloside—A bracken fern toxin—In cattle

et al. 2019

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Ptaquiloside is a natural toxin present in bracken ferns ( Pteridium sp .). Cattle ingesting bracken may develop bladder tumours and excrete genotoxins in meat and milk. However, the fate of ptaquiloside in cattle and the link between ptaquiloside and cattle carcinogenesis is unresolved. Here, we present the toxicokinetic profile of ptaquiloside in plasma and urine after intravenous administration of ptaquiloside and after oral administration of bracken. Administered intravenously ptaquiloside, revealed a volume of distribution of 1.3 L kg -1 with a mean residence-time of 4 hours. A large fraction of ptaquiloside was converted to non-toxic pterosin B in the blood stream. Both ptaquiloside and pterosin B were excreted in urine (up to 41% of the dose). Oral administration of ptaquiloside via bracken extract or dried ferns did not result in observations of ptaquiloside in body fluids, indicating deglycosolidation in the rumen. Pterosin B was detected in both plasma and urine after oral administration. Hence, transport of carcinogenic ptaquiloside metabolites over the rumen membrane is indicated. Pterosin B recovered from urine counted for 7% of the dose given intravenously. Heifers exposed to bracken for 7 days (2 mg ptaquiloside kg -1 ) developed preneoplastic lesions in the urinary bladder most likely caused by genotoxic ptaquiloside metabolites.

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“…In monogastric (single-stomach) animals, such as horses, toxicity is related to the enzyme thiaminase (Perez-Alenza et al, 2006;Vetter, 2009;Di Loria et al, 2012). In horses, thiaminase breaks into the necessary vitamin thiamine (B1), pyrimidine, and thiazole, which are inactivated in body (Knight and Walter, 2001).…”

Section: Thiamine Deficiency In Monogastricsmentioning

confidence: 99%

“…It is a lactone molecule discovered in highest concentrations in young growing parts of the plant (Perez-Alenza et al, 2006;Di Loria et al, 2012;Panter et al, 2011).…”

Section: Acute Hemorrhagic Syndrome (Loss Of Blood)mentioning

confidence: 99%

Multiple Effects of Bracken Fern under in vivo and in vitro Conditions

Tourchi-Roudsari

2014

Asian Pacific Journal of Cancer Prevention

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Clinico-pathological findings in cattle exposed to chronic bracken fern toxicity

Abstract: Monocytosis, detected in 31% of the younger animals, could represent an initial response to consumption of bracken fern and might be useful as an early haematological marker of BEH.

Cited by 20 publications

References 17 publications

Assessment of the occurrence and cause of bloody urine in cattle and management practices in Cheliya, Jibat, and Dire Inchini districts of the West Shewa Zone, Oromia, Ethiopia

Assessment of the occurrence and cause of bloody urine in cattle and management practices in Cheliya, Jibat, and Dire Inchini districts of the West Shewa Zone, Oromia, Ethiopia

Fate of ptaquiloside—A bracken fern toxin—In cattle

Multiple Effects of Bracken Fern under in vivo and in vitro Conditions

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