Clinico pathological presentation of carcinoma of breast at tertiary care centre in Vindhya region, Rewa, Madhya Pradesh, India

Abstract

INTRODUCTIONCarcinoma of the breast is one of the most common cancer affecting women worldwide. It is second common cancer after Carcinoma cervix in India. Globally, it accounts for 25% of female cancers and 18% of death from cancer in women. 1The incidence, clinical presentation and survival rates vary in different geographic areas and among different races and ethnic communities within the same geographic region.2 Several well established factors have been associated with an increased risk of breast cancer.These include age between 35-50 yrs, male to female ratio (1:100), family history in mother and grandmother, nulliparity, early menarche and late menopause. Some other factors like radiations, use of oral contraceptive pills, smoking and obesity also increase the risk of breast ABSTRACT Background: Carcinoma breast is one of the most common cancer affecting women worldwide. In present study different factors based on one year of experience at tertiary centre in India was identified. Methods: This is a prospective analysis (2013-2014) of database from all surgical units of S.S. Medical College, Rewa, India. Results: The incidence of carcinoma (Ca) of breast was 25.83%, amongst the total admitted cancer patients. Peak incidence 31.4% was in the age range 41-50 years, with the mean age of 45.2 years. 98.5% were married and multiparous, rural, illiterate belonging to low socioeconomic status. Painful Breast mass in 54.2%, axillary swelling 50%, ulcers on the lump10%, nipple discharge in 8.5% were found in the patients. Right breast involved more than left, upper outer quadrant was most commonly involved (61.4%).Most of the patients of carcinoma breast presented in stage II 32 (45.7%) followed by 23 (32.8%) in stage III, 12 (17.1%) patients presented with stage IV diseases while only three (4.2%) patients in stage I disease. 70% patients underwent surgical management. Modified Radical Mastectomy (MRM) was the most frequently performed operative procedure contributing for 37 (75.51%) cases followed by simple mastectomy in 16.32% cases. In Histopathology examination, infiltrating ductal carcinoma was the most common type of carcinoma accounting for 80.7% patients. 71.42% patients received chemotherapy. Conclusions: Finally it is concluded from this study that Ca of breast is a most common malignancy of breast in females in India. Most patients present in the late stage of disease due to inadequate education, lack of awareness of the diseases, its complications and hesitancy to report a doctor early. The main treatment of Ca of breast is surgery and chemotherapy and/or radiotherapy to prevention of local or regional recurrence and metastasis that occur in the course of disease.

Evaluation of Hormone receptor status in patients with operable breast cancer: a retrospective study at a Regional Cancer Centre in Northeast India

“…So in comparison to a study in Madhya Pradesh, more patients in our study were from very low socio-economic status family. 17 In this study, majority of the patients (59.4%) were in the age group of 31-50 years, similar to the findings of previous studies in other highincidence regions in southern india. 18 In contrast to our findings, 37-42.0% of the patients belonged to the age group of 41-50 years in maximum studies of India.…”

“…In this present study, 55.6% patients were illiterate which is almost similar to other studies in India 16,17 and only 18 patient (10.0%) were from higher socio-economic status (Class-I and II). 50.0%, 30.0%, and 10.0% of the total 180 patients were found to be in poor socio-economic classes-III, IV, and V respectively.…”

“…29 Invasive ductal carcinoma was the most common histopathology accounting for (96.1%) followed by invasive lobular carcinomas (2.8%) and medullary carcinomas (1.1%) respectively similar to other Indian studies. 16,17,23,30,31 Similar to findings of Desai et al 32 , tumours of invasive duct carcinomas was predominantly ER-/PR-(49.7%) in our study. In the present study, more number of patients (50.0%) were ER-/PR-and less number of patients (36.7%) were ER+/PR+ compared to the findings of few studies 1,4,33 where percentage of ER-/PRranged from 30.7 to 42.19% and ER+/PR+ patients ranged from 56.0% to 60.4%.…”

“…18 In contrast to our findings, 37-42.0% of the patients belonged to the age group of 41-50 years in maximum studies of India. 16,17,19,20 Moreover, in few other studies in India 21,22,23…”

Significance of Serum Lactate Dehydrogenase as a Prognostic Marker and Outcome Predictor in Patients With Breast Cancer

“…Clinical staging in the study group was consistent with the research literature categorizing most patients in clinical stages II or III [ 22 , 23 ]. According to Khokher et al ., Stages II, III, and IV had stage distributions of 32%, 35%, and 23%, respectively, which did not match the results of our study [ 24 ].…”