Clinico Pathological Study of Acanthosis Nigricans and Its Correlation With Obesity and Insulin Resistance

Krishnakanth, Krishnakanth; Anandan, Sambandam; Gayathri, Rajagopal; Adikrishnan, S; Murugan, Swati M.; Sudha, R; Mahalakshmi,

doi:10.14260/jemds/2015/2233

Cited by 1 publication

(4 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a comparable study of adolescents of Cherokee Indian background, after adjusting for weight, sex, and pubertal development, the mean insulin level was greater in those with AN than subjects without ( 22 ). Similar findings were reported by several other studies ( 18 , 23 ).…”

Section: Fasting Insulin Levels and Homeostasis Model Of Insulin Resi...supporting

confidence: 93%

“…Most patients with AN have either clinical or sub-clinical insulin resistance, with higher levels of insulin than patients without AN ( 18 ). However, insulin resistance does not develop concurrently with development of AN, and in fact, may not be present until many years after the initial onset of the dermatosis.…”

Section: Fasting Insulin Levels and Homeostasis Model Of Insulin Resi...mentioning

confidence: 99%

“…As a part of health maintenance, BMI is checked indirectly with weight and height measurements. Increased BMI and in particular increased WHR is correlated with increased likelihood of metabolic alterations in both children and adults ( 18 ). The increase in adipose tissue in childhood is the most probable initial event that leads to changes in glucose metabolism and later insulin resistance, contributing to metabolic syndrome and development of AN ( 37 ).…”

Section: Bmi and Waist To Hip Ratio (Whr)mentioning

confidence: 99%

“…Several studies suggest that despite normal BMI, increased waist to hip circumference and abnormal distribution of body fat is associated with increased risk of metabolic abnormalities ( 18 , 37 , 39 ). In a study of US children in the Pacific Islands, the prevalence of AN among all healthy weight children was 2.2%, compared to 7.8% among all obese children ( 40 ).…”

Section: Bmi and Waist To Hip Ratio (Whr)mentioning

confidence: 99%

See 3 more Smart Citations

Acanthosis nigricans in the pediatric population: a narrative review of the current approach to management in primary care

Pollock¹,

Swamy²,

Tremblay³

et al. 2022

Pediatr Med

View full text Add to dashboard Cite

Objective: This narrative review aims to provide readers with a comprehensive overview of the current literature of acanthosis nigricans (AN) in the pediatric and adolescent population, including best practices for identifying the condition, with a focus on the recommended management in the primary care setting to enable early and enhanced intervention. Background: AN is frequently seen in obese and overweight children and adolescents. Current research suggests an association with insulin resistance, type 2 diabetes mellitus, and obesity, and often primary care physicians are the first point of contact for individuals with this dermatologic condition. However, identifying the condition at an early stage may be difficult. Methods: We identified case and cross-sectional studies, clinical trials, and literature reviews of pediatric AN for ages 0 to 18 years in the United States and internationally. We considered publications for background from before the year 2000 and publications for approach to management from after the year 2000. Conclusions: AN in the pediatric population can be a harbinger for underlying metabolic syndrome and insulin resistance. A thorough investigation and appropriate screening of children at risk, with a focus on early identification of the dermatologic condition and its associated comorbidities in the primary care setting, and early treatment is recommended to prevent long term consequences and decrease the risk of cardiovascular complications.

show abstract

Section: Fasting Insulin Levels and Homeostasis Model Of Insulin Resi...supporting

confidence: 93%

Section: Fasting Insulin Levels and Homeostasis Model Of Insulin Resi...mentioning

confidence: 99%

Section: Bmi and Waist To Hip Ratio (Whr)mentioning

confidence: 99%

Section: Bmi and Waist To Hip Ratio (Whr)mentioning

confidence: 99%

See 2 more Smart Citations

Acanthosis nigricans in the pediatric population: a narrative review of the current approach to management in primary care

Pollock¹,

Swamy²,

Tremblay³

et al. 2022

Pediatr Med

View full text Add to dashboard Cite

show abstract

Clinico Pathological Study of Acanthosis Nigricans and Its Correlation With Obesity and Insulin Resistance

Cited by 1 publication

References 44 publications

Acanthosis nigricans in the pediatric population: a narrative review of the current approach to management in primary care

Acanthosis nigricans in the pediatric population: a narrative review of the current approach to management in primary care

Contact Info

Product

Resources

About