Clinico-pathological study of atypical pathogens in community-acquired pneumonia: a prospective study

Zaki, Maysaa El Sayed; Goda, Tarek

doi:10.3855/jidc.36

Cited by 14 publications

(9 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For patients with CAP, our results showed similar bacterial profiles to those reported by the international,4 and local10 studies. However, our results showed higher prevalence of the so-called atypical organisms.…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Bacterial Profile, Antibiotic Sensitivity and Resistance of Lower Respiratory Tract Infections in Upper Egypt

Agmy¹,

Salim

Gad³

et al. 2013

Mediterr J Hematol Infect Dis

View full text Add to dashboard Cite

BackgroundLower respiratory tract infections (LRTI) account for a considerable proportion of morbidity and antibiotic use. We aimed to identify the causative bacteria, antibiotic sensitivity and resistance of hospitalized adult patients due to LRTI in Upper Egypt.MethodsA multicentre prospective study was performed at 3 University Hospitals for 3 years. Samples included sputum or bronchoalveolar lavage (BAL) for staining and culture, and serum for serology. Samples were cultured on 3 bacteriological media (Nutrient, Chocolate, MacConkey's agars). Colonies were identified via MicroScan WalkAway-96. Pneumoslide IgM kit was used for detection of atypical pathogens via indirect immunofluorescent assay.ResultsThe predominant isolates in 360 patients with CAP were S. pneumoniae (36%), C. pneumoniae (18%), and M. pneumoniae (12%). A higher sensitivity was recorded for moxifloxacin, levofloxacin, macrolides, and cefepime. A higher of resistance was recorded for doxycycline, cephalosporins, and β-lactam-β-lactamase inhibitors. The predominant isolates in 318 patients with HAP were, methicillin-resistant Staphylococcus aureus; MRSA (23%), K. pneumoniae (14%), and polymicrobial in 12%. A higher sensitivity was recorded for vancomycin, ciprofloxacin, and moxifloxacin. Very high resistance was recorded for β-lactam-β-lactamase inhibitors and cephalosporins. The predominant organisms in 376 patients with acute exacerbation of chronic obstructive pulmonary diseases (AECOPD) were H. influnzae (30%), S. pneumoniae (25%), and M. catarrhalis (18%). A higher sensitivity was recorded for moxifloxacin, macrolides and cefepime. A higher rate of resistance was recorded for aminoglycosides and cephalosporins.ConclusionsThe most predominant bacteria for CAP in Upper Egypt are S. pneumoniae and atypical organisms, while that for HAP are MRSA and Gram negative bacteria. For acute exacerbation of COPD, H. influnzae was the commonest organism. Respiratory quinolones, macrolides, and cefepime are the most efficient antibiotics in treatment of LRTI in our locality.

show abstract

Section: Discussionsupporting

confidence: 89%

“…Bacterial isolates were identified by their biochemical characteristics via the automated Microscan WalkAway system (Siemens-France) 10. Isolates from repeat culture of previously recruited patients and isolates identified as commensals or contaminants were excluded.…”

Section: Methodsmentioning

confidence: 99%

Bacterial Profile, Antibiotic Sensitivity and Resistance of Lower Respiratory Tract Infections in Upper Egypt

Agmy¹,

Salim

Gad³

et al. 2013

Mediterr J Hematol Infect Dis

View full text Add to dashboard Cite

show abstract

“…However, culture is slow and FQ-PCR is expensive, and both have low sensitivity [27]. Therefore, we applied the serological method, which is rapid and practical, with considerable sensitivity, specificity and accuracy, and has thus been used in many previous studies [10,27,28]. Second, although we further examined bacterial pathogens in samples of 101 patients without M. pneumonia infection, most of them (60.4%, 61/101) remained unclear.…”

Section: Discussionmentioning

confidence: 99%

Mycoplasma pneumoniae infection in hospitalized adult patients with community-acquired pneumonia in China

Shangguan

Sun

Zhang

et al. 2014

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: This study aimed to investigate the prevalence, clinical and radiographic features, and antibiotic responses of Mycoplasma pneumoniae (M. pneumoniae) infections in hospitalized adults with community-acquired pneumonia (CAP) in China. Methodology: Serum specimens collected from 189 CAP patients in both acute phase and convalescence were tested for IgG, IgA, and IgM mixed antibodies specific to M. pneumoniae. The clinical and radiographic characteristics and efficacy of three antibiotic regimens were compared between patients with M. pneumoniae infection and those without. Results: Among 189 CAP patients, 88 (46.6%) were positive for M. pneumoniae infection. Compared to the negative patients, patients with M. pneumoniae infection were significantly younger, had higher rates of dry cough, and had white blood cell counts of <10 10 /L, but had less purulent sputum. Radiography further showed more centrilobular nodules, ground-glass opacities, tree-in-bud patterns and thickened bronchovascular bundles, but less pleural effusion and larger tracts of real opacities in patients with M. pneumoniae infections. Among the three regimens used, patients with moxifloxacin required significantly shorter fever abatement, treatment, and hospitalization times than those with azithromycin plus ceftriaxone and ceftriaxone only. Conclusions: M. pneumoniae infection was present in almost half of the CAP population in east China, with some distinct clinical and radiographic features. Moxifloxacin was an effective antibiotic for this infection.

show abstract

“…causing LRTI in children was studied in Egypt [12]. HAdV was also detected using serological methods in 30% of the patients [13]. The clinical presentation of RSV and non-RSV infected children were recently compared in Egypt [14].…”

Section: Introductionmentioning

confidence: 99%

Viral etiologies of lower respiratory tract infections among Egyptian children under five years of age

et al. 2012

View full text Add to dashboard Cite

BackgroundLower respiratory tract infections (LRTI) are responsible for a considerable number of deaths among children, particularly in developing countries. In Egypt and the Middle East region, there is a lack of data regarding the viral causes of LRTI. In this study, we aimed to identify the relative prevalence of various respiratory viruses that contribute to LRTIs in young children. Although, nucleic acid-based methods have gained importance as a sensitive tool to determine the viral infections, their use is limited because of their prohibitive cost in low-income countries. Therefore, we applied three different laboratory methods, and presented the different virus prevalence patterns detected by each method.MethodsWe collected nasopharyngeal aspirate samples, demographic data and, clinical data from 450 children under five years of age who presented with LRTI at Abou El Reesh hospital in Cairo during a one-year period. To identify the viral causes of the LRTI we used direct fluorescence assay, real-time reverse-transcriptase polymerase chain reaction (rt-RT-PCR), and shell vial culture. We tested for eight major respiratory viruses.ResultsTwo hundred sixty-nine patients (59.9%) had a viral infection, among which 10.8% had a co-infection with two or more viruses. By all three methods, respiratory syncytial virus (RSV) was the most predominant, and parainfluenza virus type 2 (HPIV-2), influenza B virus (FLUBV) were the least predominant. Other viral prevalence patterns differed according to the detection method used. The distribution of various viruses among different age groups and seasonal distribution of the viruses were also determined.ConclusionsRSV and human adenovirus were the most common respiratory viruses detected by rt-RT-PCR. Co-infections were found to be frequent among children and the vast majority of co-infections were detected by nucleic acid-based detection assays.

show abstract

Clinico-pathological study of atypical pathogens in community-acquired pneumonia: a prospective study

Cited by 14 publications

References 21 publications

Bacterial Profile, Antibiotic Sensitivity and Resistance of Lower Respiratory Tract Infections in Upper Egypt

Bacterial Profile, Antibiotic Sensitivity and Resistance of Lower Respiratory Tract Infections in Upper Egypt

Mycoplasma pneumoniae infection in hospitalized adult patients with community-acquired pneumonia in China

Viral etiologies of lower respiratory tract infections among Egyptian children under five years of age

Contact Info

Product

Resources

About